{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:44:05Z","timestamp":1787071445427,"version":"build-2736575974"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>\n                    SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteitis), a rare inflammatory disorder, is an association of distinct skin disorders with pustules with osteoarticular inflammation. Its etiology remains unclear, and various treatment regimens frequently fail to control the disease. An 18-year-old male patient presented to the outpatient department with severe nodulocystic acne on the face with pain at both the wrists and lower back associated with high-grade fever and chills. On physical examination, he had severe tenderness at both wrist joints and lower back, along with swelling of right wrist. Magnetic resonance imaging revealed osteitis of the distal end of the right radius. Technetium-99m-MDP Whole Body Bone Scan revealed increased metaphyseal uptake in distal radius on both sides and prominent uptake at the sacroiliac joints, vertebral end plate, left 7\n                    <jats:sup>th<\/jats:sup>\n                    costo-vertebral joint and bilateral sternoclavicular joints and manubrium sternum (resulting in \u201cbull's head\u201d sign, which is characteristic of SAPHO syndrome). He responded very well to a combination therapy of nonsteroid anti-inflammatory drugs, antibiotics, colchicine, and isotretinoin over a 12-week period.\n                  <\/jats:p>","DOI":"10.4103\/2229-5178.190495","type":"journal-article","created":{"date-parts":[[2016,9,15]],"date-time":"2016-09-15T03:19:58Z","timestamp":1473909598000},"page":"414-417","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":10,"title":["SAPHO syndrome with acne fulminans and severe polyosteitis involving axial skeleton"],"prefix":"10.4103","volume":"7","author":[{"given":"B Lakshmi","family":"Divya","sequence":"first","affiliation":[{"name":"Department of Dermatology, Bhaskar Medical College, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P Narasimha","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Bhaskar Medical College, Telangana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20260327","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s00586-004-0791-4","article-title":"Isolated thoracic spine lesion: Is this the presentation of a SAPHO syndrome? A case report","volume":"14","author":"Court","year":"2005","journal-title":"Eur Spine J"},{"key":"R2-20260327","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jbspin.2006.06.006","article-title":"Valuable lessons from SAPHO syndrome","volume":"74","author":"Hayem","year":"2007","journal-title":"Joint Bone Spine"},{"key":"R3-20260327","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00256-003-0629-x","article-title":"SAPHO: Syndrome or concept? 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