{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:30:05Z","timestamp":1787877005305,"version":"build-2784847793"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Polycystic ovary syndrome (PCOS) is a common endocrinopathy of women of child-bearing age. Although some studies have suggested an association between PCOS and autoimmune thyroiditis, to our knowledge, only a few cases indicating association between PCOS and Graves\u2019 disease are reported.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We aim to describe this first case series of six women presenting with PCOS and Graves\u2019 disease together.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Women attending the endocrinology clinic at a tertiary care centre in north India and fulfilling the AE-PCOS criteria for diagnosis of PCOS were studied using a predefined proforma for any clinical, biochemical and imaging features of Graves\u2019 disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The series consisted of six women with a mean age of 27.5 years and menarche as 12.6 years. All women were lean with mean BMI of 22.73 kg \/ m\n                      <jats:sup>2<\/jats:sup>\n                      and three out of six had waist circumference &lt;80 cm. The mean FG score of subjects was 16.66 and average total testosterone was 77.02 ng \/ dl (25.0-119.64). All the patients had suppressed TSH, the average being 0.052 \u03bcIU\/ml (0.01-0.15). Thyroid gland was enlarged in all clinically and on ultrasonography and imaging with\n                      <jats:sup>99m<\/jats:sup>\n                      Tc and\/or RAIU revealed diffuse increased uptake.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The association of a rare disorder like Graves\u2019 disease with a relatively common disorder like PCOS is unlikely to be because of a chance alone and may point to a common aetiopathogenic linkage leaving a scope for molecular characterization.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/2230-8210.103006","type":"journal-article","created":{"date-parts":[[2012,10,31]],"date-time":"2012-10-31T06:32:19Z","timestamp":1351665139000},"page":"982-986","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":22,"title":["Association of polycystic ovary syndrome and Graves\u2019 disease: Is autoimmunity the link between the two diseases"],"prefix":"10.4103","volume":"16","author":[{"given":"Sobia","family":"Nisar","sequence":"first","affiliation":[{"name":"Department of Medicine, Government Medical College, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parvez A.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Medicine, Government Medical College, Srinagar, Jammu and Kashmir, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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