{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:44:56Z","timestamp":1787071496341,"version":"build-2736575974"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p>Lipodystrophy is a clinical disorder characterized by maldistribution of body fat. Hyperinsulinemia, insulin resistance, and abnormalities of glucose homeostasis are commonly described among these patients. Hyperinsulinemia is also involved in the pathogenesis of polycystic ovarian syndrome, a condition, described rarely in patients with lipodystrophy. Here, we describe 2 females of partial lipodystrophy who presented with features of polycystic ovarian disease. Both had severe hyperinsulinemia and irregular periods, one had hyperandrogenism and hirsuitism while the other was non-hirsuite.<\/jats:p>","DOI":"10.4103\/2230-8210.103031","type":"journal-article","created":{"date-parts":[[2012,10,31]],"date-time":"2012-10-31T06:32:19Z","timestamp":1351665139000},"page":"1022-1025","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Polycystic ovarian syndrome in patients with lipodystrophy: Report of 2 cases with review of literature"],"prefix":"10.4103","volume":"16","author":[{"given":"Isha","family":"Pahuja","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Dr. Ram Manohar Lohia Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasanjit","family":"De","sequence":"additional","affiliation":[{"name":"Department of Radiology, Dr. Ram Manohar Lohia Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neera","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pathology and Bio-chemistry, Dr. Ram Manohar Lohia Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bindu","family":"Kulshreshtha","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Dr. Ram Manohar Lohia Hospital, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20260327","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.ecl.2004.03.003","article-title":"Lipodystrophies: Rare disorders causing metabolic syndrome","volume":"33","author":"Garg","year":"2004","journal-title":"Endocrinol Metab Clin North Am"},{"key":"R2-20260327","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1016\/S1098-3597(06)80039-6","article-title":"Adipose tissue dysfunction in obesity and lipodystrophy","volume":"84","author":"Garg","year":"2006","journal-title":"Clin Cornerstone"},{"key":"R3-20260327","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/S1043-2760(00)00309-X","article-title":"Lipoatrophy revisited","volume":"11","author":"Reitman","year":"2000","journal-title":"Trends Endocrinol Metab"},{"key":"R4-20260327","first-page":"774","article-title":"Insulin resistance and the polycystic ovary syndrome: Mechanism and implicationsfor pathogenesis","volume":"18","author":"Dunaif","year":"1997","journal-title":"Endocr Rev"},{"key":"R5-20260327","first-page":"2001","article-title":"Insulin stimulates testosterone biosynthesis by human thecal cells from women with polycystic ovary syndrome by activating its own receptor and using inositolglycan mediators as the signal transduction system","volume":"83","author":"Nestler","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"R6-20260327","first-page":"722","article-title":"Lipodystrophy (syndromes). Endocrinology, (Adult and paediatric) by J Larry Jameson Laslie J degroot","volume":"1","author":"ChuanyunGao","year":"2010"},{"key":"R7-20260327","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1136\/jmg.2008.059485","article-title":"Site dependent differences in both prelamin A and adipogenic genes in subcutaneous adipose tissues of patients with type 2 familial partial lipodystrophy","volume":"46","author":"Ara\u00fajo-Vilar","year":"2009","journal-title":"J Med Genet"},{"key":"R8-20260327","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1056\/NEJMra025261","article-title":"Acquired and inherited lipodystrophies","volume":"350","author":"Garg","year":"2004","journal-title":"N Engl J Med"},{"key":"R9-20260327","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/00005792-200303000-00007","article-title":"Clinical features and metabolic derangements in acquired generalized lipodystrophy: Case reports and review of the literature","volume":"82","author":"Misra","year":"2003","journal-title":"Medicine (Baltimore)"},{"key":"R10-20260327","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/ncpendmet0755","article-title":"Cardiometabolic features of polycystic ovary syndrome","volume":"4","author":"Hoffman","year":"2008","journal-title":"Nat Clin Pract Endocrinol Metab"},{"key":"R11-20260327","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.metabol.2006.12.021","article-title":"The adipose cell lineage is not intrinsically insulin resistant in polycystic ovary syndrome","volume":"56","author":"Corbould","year":"2007","journal-title":"Metabolism"},{"key":"R12-20260327","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.4158\/EP.14.9.1126","article-title":"Prevalence of reproductive abnormalities among women with familial partial lipodystrophy","volume":"14","author":"Joy","year":"2008","journal-title":"Endocr Pract"},{"key":"R13-20260327","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1210\/jc.2007-2521","article-title":"Fertility and obstertrical complications in women with LMNA- related familial partial lipodystrophy","volume":"93","author":"Vantyghem","year":"2008","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Indian Journal of Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/02223308-201216060-00030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:47:00Z","timestamp":1787068020000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/02223308-201216060-00030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.4103\/2230-8210.103031","relation":{},"ISSN":["2230-8210","2230-9500"],"issn-type":[{"value":"2230-8210","type":"print"},{"value":"2230-9500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}