{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T05:10:32Z","timestamp":1792905032975,"version":"4.5.0"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:p>Pituitary thyrotroph hyperplasia with hyperprolactinemia has been described as a rare presentation of primary hypothyroidism. Premenopausal females with this disorder can present with features of hypothyroidism, menstrual disturbances, galactorrhea, and visual field defects because of enlarged pituitary. Here we describe a 32-year-old female presenting to her gynecologist primarily with galactorrhea and secondary amenorrhea. She was found to have raised serum prolactin, and MRI brain showed enlarged pituitary. She was referred for pituitary surgery when she came to us. Clinical examination and biochemistry were suggestive of primary hypothyroidism. She was prescribed levothyroxine replacement. At 6 weeks follow-up, serum prolactin came down to normal, galactorrhea subsided, and spontaneous menstrual cycles resumed. In 12 weeks, pituitary enlargement completely regressed and in another month after that, she conceived. Hence, primary hypothyroidism can present with thyrotroph hyperplasia, where correct diagnosis and levothyroxine therapy can prevent unnecessary pituitary surgery. Hyperprolactinemia in this setting is of no clinical significance.<\/jats:p>","DOI":"10.4103\/2230-8210.103036","type":"journal-article","created":{"date-parts":[[2012,10,31]],"date-time":"2012-10-31T06:32:19Z","timestamp":1351665139000},"page":"1037-1039","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Reversible thyrotroph hyperplasia with hyperprolactinemia: A rare presenting manifestation of primary hypothyroidism"],"prefix":"10.4103","volume":"16","author":[{"given":"Rajesh","family":"Rajput","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Medicine, Unit VI, Pt. B.D. Sharma PGIMS, Rohtak, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Sehgal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pt. B.D. Sharma PGIMS, Rohtak, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Gahlan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Pt. B.D. Sharma PGIMS, Rohtak, Haryana, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20260327","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1507\/endocrj.44.89","article-title":"Incidence of hyperprolactinemia in patients with Hashimoto's thyroiditis","volume":"44","author":"Notsu","year":"1997","journal-title":"Endocr J"},{"key":"R2-20260327","first-page":"575","article-title":"Diagnosis and management of hyperprolactinemia","volume":"169","author":"Seri","year":"2003","journal-title":"CMAJ"},{"key":"R3-20260327","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1507\/endocrj.K10E-215","article-title":"The prevalence of hyperprolactinemia in overt and subclinical hypothyroidism","volume":"57","author":"Hekimsoy","year":"2010","journal-title":"Endocr J"},{"key":"R4-20260327","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1046\/j.1365-2265.2003.01694.x","article-title":"Hyperprolactinaemia in hypothyroidism: Clinical significance and impact of TSH normalization","volume":"58","author":"Raber","year":"2003","journal-title":"Clin Endocrinol (Oxf)"},{"key":"R5-20260327","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1089\/105072503322511391","article-title":"Prolactin dysregulation in women with subclinical hypothyroidism: Effect of levothyroxine replacement therapy","volume":"13","author":"Meier","year":"2003","journal-title":"Thyroid"},{"key":"R6-20260327","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/TEN.0b013e3181ecb07d","article-title":"A case of pituitary hyperplasia secondary to primary hypothyroidism presenting with irregular menses, galactorrhea, and hyperprolactinemia","volume":"20","author":"Erem","year":"2010","journal-title":"Endocrinologist"},{"key":"R7-20260327","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1210\/jc.2010-2011","article-title":"Large pituitary hyperplasia in severe primary hypothyroidism","volume":"96","author":"Passeri","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"R9-20260327","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1046\/j.1440-1673.1999.00610.x","article-title":"Residual pituitary enlargement in primary hypothyroidism despite 1 1\/2 years of L-thyroxine therapy","volume":"43","author":"Goswami","year":"1999","journal-title":"Australas Radiol"},{"key":"R10-20260327","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/01.ten.0000113246.79886.1f","article-title":"Lymphocytic hypophysitis","volume":"14","author":"Breen","year":"2004","journal-title":"Endocrinologist"}],"container-title":["Indian Journal of Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/02223308-201216060-00035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:47:02Z","timestamp":1787068022000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/02223308-201216060-00035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.4103\/2230-8210.103036","relation":{},"ISSN":["2230-8210","2230-9500"],"issn-type":[{"value":"2230-8210","type":"print"},{"value":"2230-9500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}