{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T08:19:01Z","timestamp":1791188341302,"version":"4.1.0"},"reference-count":110,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Indian J Endocr Metab"],"published-print":{"date-parts":[[2012]]},"DOI":"10.4103\/2230-8210.105575","type":"journal-article","created":{"date-parts":[[2013,1,4]],"date-time":"2013-01-04T02:29:23Z","timestamp":1357266563000},"page":"577","source":"Crossref","is-referenced-by-count":43,"title":["Leptin in pediatrics: A hormone from adipocyte that wheels several functions in children"],"prefix":"10.4103","volume":"16","author":[{"given":"AshrafT","family":"Soliman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Yasin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Kassem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/2230-8210.105575-1","first-page":"RA282","volume-title":"Leptin-from a signal of adiposity to a hormone mediator in peripheral tissues","author":"Baratta","year":"2002","journal-title":"Med Sci Monit"},{"key":"key-10.4103\/2230-8210.105575-2","first-page":"763","volume-title":"Leptin and the regulation of body weight in mammals","author":"Friedman","year":"1998","journal-title":"Nature"},{"key":"key-10.4103\/2230-8210.105575-3","first-page":"539","volume-title":"Energy balance in obesity","author":"Webber","year":"2003","journal-title":"Proc Nutr Soc"},{"key":"key-10.4103\/2230-8210.105575-4","first-page":"1537","volume-title":"Expression of the long and short leptin receptor isoforms in peripheral blood mononuclear cells: Implications for leptin\u2032s actions","author":"Tsiotra","year":"2000","journal-title":"Metabolism"},{"key":"key-10.4103\/2230-8210.105575-5","doi-asserted-by":"crossref","unstructured":"Trayhurn P, Hoggard N, Mercer JG, Rayner DV. Leptin: Fundamental aspects. Int J Obes Relat Metab Disord 1999;23(Suppl 1):S22-8.","DOI":"10.1038\/sj.ijo.0800791"},{"key":"key-10.4103\/2230-8210.105575-6","first-page":"982","volume-title":"Soluble leptin receptor represents the main leptin binding activity in human blood","author":"Lammert","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"key-10.4103\/2230-8210.105575-7","first-page":"244","volume-title":"Measurement of leptin and leptin binding in the human circulation","author":"Wallace","year":"2000","journal-title":"Ann Clin Biochem"},{"key":"key-10.4103\/2230-8210.105575-8","first-page":"1","volume-title":"Distribution, function, and properties of leptin receptors in the brain","author":"Funahashi","year":"2003","journal-title":"Int Rev Cytol"},{"key":"key-10.4103\/2230-8210.105575-9","first-page":"221","volume-title":"Leptin and the Control of Body Weight: A Review of Its Diverse Central Targets, Signaling Mechanisms, and Role in the Pathogenesis of Obesity","author":"Oswal","year":"2010","journal-title":"Obesity (Silver spring)"},{"key":"key-10.4103\/2230-8210.105575-10","doi-asserted-by":"crossref","unstructured":"Cammisotto P, Bendayan M. A review on gastric leptin: The exocrine secretion of a gastric hormone. Anat Cell Biol 2012;45:1-15.","DOI":"10.5115\/acb.2012.45.1.1"},{"key":"key-10.4103\/2230-8210.105575-11","doi-asserted-by":"crossref","unstructured":"Margetic S, Gazzola C, Pegg GG, Hill RA. Leptin: A review of its peripheral actions and interactions. Int J Obes Relat Metab Disord 2002;26:1407-33.","DOI":"10.1038\/sj.ijo.0802142"},{"key":"key-10.4103\/2230-8210.105575-12","first-page":"875","volume-title":"Integrative physiology of human adipose tissue","author":"Frayn","year":"2003","journal-title":"Int J Obes Relat Metab Disord"},{"key":"key-10.4103\/2230-8210.105575-13","first-page":"555","volume-title":"Circadian rhythm of blood leptin in obese and non-obese people","author":"Radic","year":"2003","journal-title":"Coll Antropol"},{"key":"key-10.4103\/2230-8210.105575-14","first-page":"258","volume-title":"Simultaneous and continuous 24-hour plasma and cerebrospinal fluid leptin measurements: Dissociation of concentrations in central and peripheral compartments","author":"Wong","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/2230-8210.105575-15","first-page":"287457","volume-title":"Leptin in anorexia and cachexia syndrome","author":"Engineer","year":"2012","journal-title":"Int J Pept"},{"key":"key-10.4103\/2230-8210.105575-16","first-page":"120","volume-title":"Hypothalamic regulation of food intake and clinical therapeutic application","author":"Simpson","year":"2009","journal-title":"Arq Bras Endocrinol Metabol"},{"key":"key-10.4103\/2230-8210.105575-17","first-page":"301","volume-title":"Brain regulation of food intake and appetite: Molecules and networks","author":"Broberge","year":"2005","journal-title":"J Intern Med"},{"key":"key-10.4103\/2230-8210.105575-18","first-page":"78","volume-title":"\"Fuel utilization by hypothalamic neurons: Roles for ROS","author":"Horvath","year":"2009","journal-title":"\" Trends Endocrinol Metab"},{"key":"key-10.4103\/2230-8210.105575-19","first-page":"623","volume-title":"Hypothalamic regulation of energy homeostasis","author":"Sainsbury","year":"2002","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"key-10.4103\/2230-8210.105575-20","first-page":"1000","volume-title":"Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice","author":"Berglund","year":"2012","journal-title":"J Clin Invest"},{"key":"key-10.4103\/2230-8210.105575-21","first-page":"472","volume-title":"Effect of Leptin on Progesterone, Human Chorionic Gonadotropin, and Interleukin-6 Secretion by Human Term Trophoblast Cells in Culture","author":"Cameo","year":"2003","journal-title":"Biol Reprod"},{"key":"key-10.4103\/2230-8210.105575-22","first-page":"366","volume-title":"Neonatal leptin levels are strongly associated with female gender, birth length, IGF-I levels and formula feeding","author":"Petridou","year":"2005","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key-10.4103\/2230-8210.105575-23","first-page":"E372","volume-title":"Characterization of leptin pulse dynamics and relationship to fat mass, growth hormone, cortisol, and insulin","author":"Koutkia","year":"2003","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key-10.4103\/2230-8210.105575-24","first-page":"E1230","volume-title":"Integration of hormonal and nutrient signals that regulate leptin synthesis and secretion","author":"Lee","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"key-10.4103\/2230-8210.105575-25","first-page":"5301","volume-title":"Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP","author":"Slieker","year":"1996","journal-title":"J Biol Chem"},{"key":"key-10.4103\/2230-8210.105575-26","first-page":"1344","volume-title":"Nocturnal rise of leptin in lean, obese, and non-insulin dependent diabetes mellitus subjects","author":"Sinha","year":"1996","journal-title":"J Clin Invest"},{"key":"key-10.4103\/2230-8210.105575-27","first-page":"429","volume-title":"Serum leptin levels in patients with hyperlipidemias","author":"Haluzik","year":"2000","journal-title":"Nutrition"},{"key":"key-10.4103\/2230-8210.105575-28","first-page":"727","volume-title":"Serum leptin through childhood and adolescence","author":"Clayton","year":"1997","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key-10.4103\/2230-8210.105575-29","first-page":"579","volume-title":"Sexual dimorphism in plasma leptin concentration","author":"Saad","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/2230-8210.105575-30","first-page":"4140","volume-title":"Sex differences in circulating human leptin pulse amplitude: Clinical implications","author":"Licinio","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/2230-8210.105575-31","first-page":"342","volume-title":"Depotand sex-specific differences in human leptin mRNA expression: Implications for the control of regional fat distribution","author":"Montague","year":"1997","journal-title":"Diabetes"},{"key":"key-10.4103\/2230-8210.105575-32","first-page":"717","volume-title":"Difference in circulating concentrations of total, free and bound leptin relate to gender and body composition in adult humans","author":"McConway","year":"2000","journal-title":"Ann Clin Biochem"},{"key":"key-10.4103\/2230-8210.105575-33","first-page":"902","volume-title":"Multihormonal control of ob gene expression and leptin secretion from cultured human visceral adipose tissue: Increased responsiveness to glucocorticoids in obesity","author":"Halleux","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/2230-8210.105575-34","unstructured":"Blum WF, Juul A. Reference ranges of serum leptin. In: Blum WF, et al.,editors. Leptin-The voice of adipose tissue.Johann Ambrosius; Verlag Heidelberg; 1997. p. 318-26."},{"key":"key-10.4103\/2230-8210.105575-35","first-page":"3659","volume-title":"A twin study for serum leptin, soluble leptin receptor, and free insulin-like growth factor-I in pubertal females","author":"Li","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/2230-8210.105575-36","first-page":"61","volume-title":"Serum ghrelin levels in obese patients: The relationship to serum leptin levels and soluble leptin receptor levels","author":"Rosicka","year":"2003","journal-title":"Physiol Res"},{"key":"key-10.4103\/2230-8210.105575-37","first-page":"1568","volume-title":"Recombinant leptin for weight loss in obese and lean adults: A randomized, controlled, dose-escalation trial","author":"Heymsfield","year":"1999","journal-title":"JAMA"},{"key":"key-10.4103\/2230-8210.105575-38","first-page":"33","volume-title":"Elevated serum levels of leptin and leptin receptor in patients with advanced chronic heart failure","author":"Schulze","year":"2003","journal-title":"Eur J Heart Fail"},{"key":"key-10.4103\/2230-8210.105575-39","first-page":"1957","volume-title":"Central leptin gene therapy ameliorates diabetes type 1 and 2 through two independent hypothalamic relays; a benefit beyond weight and appetite regulation","author":"Kalra","year":"2009","journal-title":"Peptides"},{"key":"key-10.4103\/2230-8210.105575-40","first-page":"443","volume-title":"Monogenic Obesity in Humans","author":"Farooqi","year":"2005","journal-title":"Annu Rev Med"},{"key":"key-10.4103\/2230-8210.105575-41","first-page":"260","volume-title":"Growth hormone in obesity","author":"Scacchi","year":"1999","journal-title":"Int J Obes Relat Metab Disord"},{"key":"key-10.4103\/2230-8210.105575-42","first-page":"87","volume-title":"Impaired growth hormone response to growth hormone releasing factor and insulin-hypoglycemia in obesity","author":"Kopelman","year":"1985","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key-10.4103\/2230-8210.105575-43","first-page":"139","volume-title":"Serum levels of insulin-like growth factor (IGF-1), free IGF-1, IGF-binding protein (IGFBP-1), and IGFBP-3 and insulin in obese children","author":"Park","year":"1999","journal-title":"J Pediatr Endocrinol Metab"},{"key":"key-10.4103\/2230-8210.105575-44","first-page":"1142","volume-title":"Insulin-like growth factors I and II, prolactin and insulin in 19 growth hormone-deficient children with excessive, normal or decreased longitudinal growth after operation for craniopharyngioma","author":"Bucher","year":"1983","journal-title":"N Engl J Med"},{"key":"key-10.4103\/2230-8210.105575-45","first-page":"1467","volume-title":"The metabolic syndrome and insulin-like growth factor I regulation in adolescent obesity","author":"Attia","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/2230-8210.105575-46","first-page":"321","volume-title":"Growth without growth hormone: The \u2032invisible\u2032 GH syndrome","author":"Bistritzer","year":"1988","journal-title":"Lancet"},{"key":"key-10.4103\/2230-8210.105575-47","first-page":"1034","volume-title":"Leptin acts as a growth factor on the chondrocytes of skeletal growth centers","author":"Maor","year":"2002","journal-title":"J Bone Mineral Res"},{"key":"key-10.4103\/2230-8210.105575-48","first-page":"700","volume-title":"Insulin resistance syndrome in childhood: Association of the euglycemic insulin clamp and fasting insulin with fatness and other risk factors","author":"Sinaiko","year":"2001","journal-title":"J Pediatr"},{"key":"key-10.4103\/2230-8210.105575-49","first-page":"469","volume-title":"Adiposity in childhood predicts insulin resistance and obesity in young adulthood","author":"Steinberger","year":"2001","journal-title":"J Pediatr"},{"key":"key-10.4103\/2230-8210.105575-50","first-page":"54","volume-title":"Persistent elevation of plasma insulin levels is associated with increased cardiovascular risk in children and young adults.The Bogalusa Heart Study","author":"Bao","year":"1996","journal-title":"Circulation"},{"key":"key-10.4103\/2230-8210.105575-51","first-page":"1265","volume-title":"Plasma leptin concentrations and obesity in relation to insulin resistance syndrome components among school children in Taiwan-The Taipei Children Heart Study","author":"Chu","year":"2000","journal-title":"Int J Obes Relat Metab Disord"},{"key":"key-10.4103\/2230-8210.105575-52","first-page":"385","volume-title":"Serum leptin and insulin concentrations in prepubertal lean, obese and insulin-dependent diabetes mellitus children","author":"Kamoda","year":"1998","journal-title":"Clin Endocrinol(Oxf)"},{"key":"key-10.4103\/2230-8210.105575-53","first-page":"923","volume-title":"Insulin and insulin resistance index are not independent determinants for the variation in leptin in obese children and adolescents","author":"Sudi","year":"2000","journal-title":"J Pediatr Endocrinol Metab"},{"key":"key-10.4103\/2230-8210.105575-54","first-page":"819","volume-title":"Serum leptin concentrations during severe protein-energy malnutrition: Correlation with growth parameters and endocrine function","author":"Soliman","year":"2000","journal-title":"Metabolism"},{"key":"key-10.4103\/2230-8210.105575-55","first-page":"534","volume-title":"Serum leptin concentrations in children with mild protein-energy malnutrition and catch-up growth","author":"B\u00fcy\u00fckgebiz","year":"2004","journal-title":"Pediatr Int"},{"key":"key-10.4103\/2230-8210.105575-56","first-page":"523","volume-title":"Leptin Functioning in Eating Disorders","author":"Monteleone","year":"2004","journal-title":"CNS Spectr"},{"key":"key-10.4103\/2230-8210.105575-57","first-page":"5169","volume-title":"Elevated physical activity and low leptin levels co-occur in patients with anorexia nervosa","author":"Holtkamp","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/2230-8210.105575-58","first-page":"330","volume-title":"Leptin levels in patients with anorexia nervosa are reduced in the acute stage and elevated upon short-term weight restoration","author":"Hebebrand","year":"1997","journal-title":"Mol Psychiatry"},{"key":"key-10.4103\/2230-8210.105575-59","first-page":"165","volume-title":"The effect of therapeutically induced weight gain on plasma leptin levels in patients with anorexia nervosa","author":"Holtkamp","year":"2003","journal-title":"J Psychiatr Res"},{"key":"key-10.4103\/2230-8210.105575-60","first-page":"717","volume-title":"Neuroendocrine mechanisms that delay and initiate puberty in higher primates","author":"Plant","year":"2002","journal-title":"Physiol Behav"},{"key":"key-10.4103\/2230-8210.105575-61","first-page":"1023","volume-title":"Role of leptin in hypothalamic-pituitary function","author":"Yu","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"key-10.4103\/2230-8210.105575-62","first-page":"331","volume-title":"Neural substrates for leptin and neuropeptide Y (NPY) interaction: Hypothalamic sites associated with inhibition of NPY-induced food intake","author":"Yokosuka","year":"1998","journal-title":"Physiol Behav"},{"key":"key-10.4103\/2230-8210.105575-63","first-page":"1464","volume-title":"In vitro stimulation of the prepubertal rat gonadotropin-releasing-hormone pulse generator by leptin and neuropeptide Y through distinct mechanisms","author":"Lebrethon","year":"2000","journal-title":"Endocrinology"},{"key":"key-10.4103\/2230-8210.105575-64","first-page":"9","volume-title":"Hypothalamic sites of leptin action linking metabolism and reproduction","author":"Donato","year":"2011","journal-title":"Neuroendocrinology"},{"key":"key-10.4103\/2230-8210.105575-65","first-page":"4144","volume-title":"Expression of functional leptin receptors in the human ovary","author":"Karlsson","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/2230-8210.105575-66","first-page":"213","volume-title":"A leptin missense mutation associated with hypogonadism and morbid obesity","author":"Strobel","year":"1998","journal-title":"Nat Genet"},{"key":"key-10.4103\/2230-8210.105575-67","first-page":"95","volume-title":"The role of leptin in human growth and puberty","author":"Ong","year":"1999","journal-title":"Acta Paediatr Suppl"},{"key":"key-10.4103\/2230-8210.105575-68","first-page":"879","volume-title":"Effect of recombinant leptin therapy in a child with congenital leptin deficiency","author":"Farooqi","year":"1999","journal-title":"N Engl J Med"},{"key":"key-10.4103\/2230-8210.105575-69","first-page":"1093","volume-title":"Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine\/metabolic dysfunction of human congenital leptin deficiency","author":"Farooqi","year":"2002","journal-title":"J Clin Invest"},{"key":"key-10.4103\/2230-8210.105575-70","first-page":"721","volume-title":"Constitutional delay in growth and puberty (CDGP) is associated with hypoleptinaemia","author":"Gill","year":"1999","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key-10.4103\/2230-8210.105575-71","first-page":"905","volume-title":"Leptin and the sympathetic connection of fat to bone","author":"Hamrick","year":"2008","journal-title":"Osteoporos Int"},{"key":"key-10.4103\/2230-8210.105575-72","first-page":"706","volume-title":"A unified model for the action of leptin on bone turnover","author":"Gordeladze","year":"2003","journal-title":"J Cell Biochem"},{"key":"key-10.4103\/2230-8210.105575-73","first-page":"305","volume-title":"Leptin regulates bone formation via the sympathetic nervous system","author":"Takeda","year":"2002","journal-title":"Cell"},{"key":"key-10.4103\/2230-8210.105575-74","first-page":"497","volume-title":"Short-term hyperthyroidism has no effect on leptin levels in man","author":"Mantzoros","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/2230-8210.105575-75","first-page":"428","volume-title":"Role of thyroid hormones on serum leptin levels","author":"Sesmilo","year":"1998","journal-title":"Eur J Endocrinol"},{"key":"key-10.4103\/2230-8210.105575-76","first-page":"3230","volume-title":"Robust leptin secretory responses to dexamethasone in obese subjects","author":"Dagogo-Jack","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/2230-8210.105575-77","first-page":"704","volume-title":"Dexamethasone induces an acute and sustained rise in circulating leptin levels in normal human subjects","author":"Miell","year":"1996","journal-title":"Horm Metab Res"},{"key":"key-10.4103\/2230-8210.105575-78","first-page":"277(4 Pt 1)E708","volume-title":"Glucocorticoids reverse leptin effects on food intake and body fat in mice without increasing NPY mRNA","author":"Solano","year":"1999","journal-title":"Am J Physiol"},{"key":"key-10.4103\/2230-8210.105575-79","first-page":"708","volume-title":"High leptin concentrations in serum of very obese children are further stimulated by dexamethasone","author":"Kiess","year":"1996","journal-title":"Horm Metab Res"},{"key":"key-10.4103\/2230-8210.105575-80","first-page":"6","volume-title":"Human leptin stimulates proliferation and activation of human circulating monocytes","author":"Santos-Alvarez","year":"1999","journal-title":"Cell Immunol"},{"key":"key-10.4103\/2230-8210.105575-81","first-page":"311","volume-title":"Leptin enhances CC-chemokine ligand expression in cultured murine macrophage","author":"Kiguchi","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"key-10.4103\/2230-8210.105575-82","first-page":"8090","volume-title":"Apoptotic pathways are inhibited by leptin receptor activation in neutrophils","author":"Bruno","year":"2005","journal-title":"J Immunol"},{"key":"key-10.4103\/2230-8210.105575-83","first-page":"4182","volume-title":"Leptin modulates neutrophil phagocytosis of Klebsiella pneumoniae","author":"Moore","year":"2003","journal-title":"Infect Immun"},{"key":"key-10.4103\/2230-8210.105575-84","first-page":"1462","volume-title":"Leptin induces tissue factor expression in human peripheral blood mononuclear cells: A possible link between obesity and cardiovascular risk?","author":"Napoleone","year":"2007","journal-title":"J Thromb Haemost"},{"key":"key-10.4103\/2230-8210.105575-85","first-page":"505","volume-title":"Leptin promotes cell survival and activates Jurkat T lymphocytes by stimulation of mitogen-activated protein kinase","author":"Fern\u00e1ndez-Riejos","year":"2008","journal-title":"Clin Exp Immunol"},{"key":"key-10.4103\/2230-8210.105575-86","first-page":"21","volume-title":"Leptin inhibits stress-induced apoptosis of T lymphocytes","author":"Fujita","year":"2002","journal-title":"Clin Exp Immunol"},{"key":"key-10.4103\/2230-8210.105575-87","first-page":"1093","volume-title":"Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine\/metabolic dysfunction of human congenital leptin deficiency","author":"Farooqi","year":"2002","journal-title":"J Clin Invest"},{"key":"key-10.4103\/2230-8210.105575-88","first-page":"16","volume-title":"Restricted leptin antagonism as a therapeutic approach to treatment of autoimmune diseases","author":"Babaei","year":"2011","journal-title":"Hormones (Athens)"},{"key":"key-10.4103\/2230-8210.105575-89","first-page":"394","volume-title":"Decreased CD4+ lymphocyte activation and increased interleukin-4 production in peripheral blood of rheumatoid arthritis patients after acute starvation","author":"Fraser","year":"1999","journal-title":"Clin Rheumatol"},{"key":"key-10.4103\/2230-8210.105575-90","first-page":"10","volume-title":"Expression of leptin and leptin receptor during the development of liver fibrosis and cirrhosis","author":"Otte","year":"2004","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"key-10.4103\/2230-8210.105575-91","first-page":"91","volume-title":"The severity of liver fibrosis is associated with high leptin levels in chronic hepatitis C","author":"Piche","year":"2004","journal-title":"J Viral Hepat"},{"key":"key-10.4103\/2230-8210.105575-92","first-page":"983","volume-title":"Leptin-Mediated Neovascularization Is a Prerequisite for Progression of Nonalcoholic Steatohepatitis in Rats","author":"Kitade","year":"2006","journal-title":"Hepatology"},{"key":"key-10.4103\/2230-8210.105575-93","first-page":"270","volume-title":"Receptor mediated regional sympathetic nerve activation by leptin","author":"Haynes","year":"1997","journal-title":"J Clin Invest"},{"key":"key-10.4103\/2230-8210.105575-94","doi-asserted-by":"crossref","unstructured":"Matsumura K, Abe I, Tsuchihashi T, Fujishima M. Central effects of leptin on cardiovascular and neurohormonal responses in conscious rabbits. Am J Physiol Regul Integr Comp Physiol 2000;278R1314-20.","DOI":"10.1152\/ajpregu.2000.278.5.R1314"},{"key":"key-10.4103\/2230-8210.105575-95","doi-asserted-by":"crossref","unstructured":"Shirasaka T, Takasaki M, Kannan H. Cardiovascular effects of leptin and orexins. American Journal of Physiology. Regulatory. Am J Physiol Regul Integr Comp Physiol 2003;284:R639-51.","DOI":"10.1152\/ajpregu.00359.2002"},{"key":"key-10.4103\/2230-8210.105575-96","first-page":"1","volume-title":"Leptin and hyperleptinemia - from friend to foe for cardiovascular function","author":"Ren","year":"2004","journal-title":"J Endocrinol"},{"key":"key-10.4103\/2230-8210.105575-97","first-page":"108","volume-title":"The significance of measuring plasma leptin in acute myocardial infarction","author":"Fujimaki","year":"2001","journal-title":"J Int Med Res"},{"key":"key-10.4103\/2230-8210.105575-98","first-page":"32","volume-title":"Angiogenic biomarkers in children with congenital heart disease: Possible implications","author":"El-Melegy","year":"2010","journal-title":"Ital J Pediatr"},{"key":"key-10.4103\/2230-8210.105575-99","first-page":"4281","volume-title":"Congenital Leptin Deficiency Due to Homozygosity for the \u00c4133G Mutation: Report of Another Case and Evaluation of Response to Four Years of Leptin Therapy","author":"Gibson","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/2230-8210.105575-100","first-page":"903","volume-title":"Congenital leptin deficiency is associated with severe early-onset obesity in humans","author":"Montague","year":"1997","journal-title":"Nature"},{"key":"key-10.4103\/2230-8210.105575-101","first-page":"213","volume-title":"A leptin missense mutation associated with hypogonadism and morbid obesity","author":"Strobel","year":"1998","journal-title":"Nat Genet"},{"key":"key-10.4103\/2230-8210.105575-102","first-page":"1093","volume-title":"Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine\/metabolic dysfunction of human congenital leptin deficiency","author":"Farooqi","year":"2002","journal-title":"J Clin Invest"},{"key":"key-10.4103\/2230-8210.105575-103","first-page":"4531","volume-title":"Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults","author":"Licinio","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"key-10.4103\/2230-8210.105575-104","first-page":"1994","volume-title":"Long-term efficacy of leptin replacement in patients with generalized lipodystrophy","author":"Javor","year":"2005","journal-title":"Diabetes"},{"key":"key-10.4103\/2230-8210.105575-105","first-page":"27","volume-title":"Efficacy of leptin therapy in the different forms of human lipodystrophy","author":"Chong","year":"2010","journal-title":"Diabetologia"},{"key":"key-10.4103\/2230-8210.105575-106","first-page":"4813","volume-title":"Leptin therapy in insulin-deficient type I diabetes","author":"Wanga","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key-10.4103\/2230-8210.105575-107","first-page":"14670","volume-title":"Subcutaneous administration of leptin normalizes fasting plasma glucose in obese type 2 diabetic UCD-T2DM rats","author":"Cummings","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key-10.4103\/2230-8210.105575-108","first-page":"1474","volume-title":"Recombinant Human Leptin Treatment Does Not Improve Insulin Action in Obese Subjects With Type 2 Diabetes","author":"Mittendorfer","year":"2011","journal-title":"Diabetes"},{"key":"key-10.4103\/2230-8210.105575-109","first-page":"3219","volume-title":"Elevated Plasma Adiponectin in Humans with Genetically Defective Insulin Receptors","author":"Semple","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key-10.4103\/2230-8210.105575-110","first-page":"2038","volume-title":"Insulin resistance during puberty: Results from insulin clamp studies in 356 children","author":"Moran","year":"1999","journal-title":"Diabetes"}],"container-title":["Indian Journal of Endocrinology and Metabolism"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:02:12Z","timestamp":1786633332000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/2230-8210.105575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":110,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2012]]}},"alternative-id":["105575"],"URL":"https:\/\/doi.org\/10.4103\/2230-8210.105575","relation":{},"ISSN":["2230-8210"],"issn-type":[{"value":"2230-8210","type":"print"}],"subject":[],"published":{"date-parts":[[2012]]}}}