{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:18:10Z","timestamp":1792034290643,"version":"4.4.0"},"reference-count":61,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p>Cardiovascular disease (CVD) is globally considered as the leading cause of death with 80% of CVD related deaths being reported from low and middle income countries like India. The relatively early onset age of CVD in India in comparison to Western countries also implies that most productive ages of the patient's life are lost fighting the disease. Conventional cardiovascular risk is attributed to lifestyle changes and altered metabolic activity. This forms the basis of a 10-year risk prediction score inspired by the Framingham study. Since South Asians display considerable heterogeneity in risk factors as compared to developed countries, there is a need to identify risk factors which would not only help in primary prevention but also prevent their recurrence. We reviewed published data on novel risk factors and their potential to identify cardiovascular risk at an early stage, with special emphasis on the Indian population. Emerging risk factors were reviewed to identify their potential to prevent CVD progression independently as well as in association with other cardiovascular risk factors. The most commonly studied emerging cardiovascular risk factors included coronary artery calcium score, lipoprotein (a), apolipoproteins, homocysteine, thrombosis markers like fibrinogen, and plasminogen activator inhibitor 1, carotid intima-media thickness, genotypic variations, non-alcoholic fatty liver disease, C-reactive protein, platelets, and birth weight levels. Nonetheless, more studies on large sample size can ascertain the utility of these risk factors in estimation and analysis of cardiovascular risk especially in the Indian context.<\/jats:p>","DOI":"10.4103\/2230-8210.117212","type":"journal-article","created":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T01:48:18Z","timestamp":1377740898000},"page":"806-814","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":54,"title":["Emerging risk factors for cardiovascular diseases: Indian context"],"prefix":"10.4103","volume":"17","author":[{"given":"Sushil","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Sanjay Gandhi PGI, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Gudapati","sequence":"additional","affiliation":[{"name":"Interventional Cardiologist, Star Hospital, Hyderabad, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumar","family":"Gaurav","sequence":"additional","affiliation":[{"name":"Astra Zeneca India Ltd., Bangalore, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj","family":"Bhise","sequence":"additional","affiliation":[{"name":"Interventional Cardiologist, Inlex Hospital, Pune, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20260327","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1016\/S0140-6736(96)07492-2","article-title":"Alternative projections of mortality and disability by cause 1990-2020: Global Burden of Disease Study","volume":"349","author":"Murray","year":"1997","journal-title":"Lancet"},{"key":"R2-20260327","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1136\/hrt.2007.132951","article-title":"Epidemiology and causation of coronary heart disease and stroke in India","volume":"94","author":"Gupta","year":"2008","journal-title":"Heart"},{"key":"R3-20260327","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1016\/S0140-6736(05)67343-6","article-title":"Responding to the challenge of chronic diseases in India","volume":"366","author":"Reddy","year":"2005","journal-title":"Lancet"},{"key":"R4-20260327","first-page":"115","article-title":"Cadiovascular risk factors in developing countries: A review of clinico-epidemiological evidence","volume":"5","author":"Prasad","year":"2010","journal-title":"CVD Prev Control"},{"key":"R5-20260327","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1161\/01.CIR.97.18.1837","article-title":"Prediction of coronary heart disease using risk factor categories","volume":"97","author":"Wilson","year":"1998","journal-title":"Circulation"},{"key":"R6-20260327","doi-asserted-by":"crossref","first-page":"587","DOI":"10.4103\/IJMR.2010_132_05_584","article-title":"Diabetes and coronary heart disease: Current perspectives","volume":"132","author":"Ali","year":"2010","journal-title":"Indian J Med Res"},{"key":"R8-20260327","first-page":"165","article-title":"Recommendations of the second Indo-US health summit on prevention and control of cardiovascular disease among Asian Indians","volume":"61","author":"Enas","year":"2009","journal-title":"Indian Heart J"},{"key":"R9-20260327","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.disamonth.2006.01.002","article-title":"Elevated lipoprotein (a) - a genetic risk factor for premature vascular disease in people with and without standard risk factors: A review","volume":"52","author":"Enas","year":"2006","journal-title":"Dis Mon"},{"key":"R10-20260327","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.atherosclerosissup.2006.01.003","article-title":"CVD risk factors and ethnicity: A homogeneous relationship?","volume":"7","author":"Forouhi","year":"2006","journal-title":"Atheroscler Suppl"},{"key":"R11-20260327","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1161\/01.CIR.101.1.111","article-title":"AHA Conference Proceedings: Prevention Conference V: beyond secondary prevention: Identifying the high-risk patient for primary prevention: Executive summary: American Heart Association","volume":"101","author":"Smith","year":"2000","journal-title":"Circulation"},{"key":"R12-20260327","doi-asserted-by":"crossref","first-page":"2486","DOI":"10.1001\/jama.285.19.2486","article-title":"Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. 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