{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:45:16Z","timestamp":1787071516251,"version":"build-2736575974"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Onset of puberty in boys usually occurs by 14 years of age. Some boys may exhibit delayed sexual maturation till about 17-18 years of age. However, pubertal onset beyond 18 years of age is exceedingly rare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Patients diagnosed as idiopathic hypogonadotropic hypogonadism (IHH) who had onset of puberty (increase in testicular volume &gt;10 ml) while on androgen therapy were studied. These patients were evaluated prospectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>There were nine subjects that were included in the study. The pre-therapy testicular volumes ranged from 3 to 6 ml. Luteinizing hormone (LH) levels increased from 1.2 \u00b1 0.96 to 2.8 \u00b1 1.0 IU\/L, follicular stimulating hormone (FSH) levels increased from 1.5 \u00b1 0.79 to 3.5 \u00b1 1.9 IU\/L, and testosterone increased from 0.36 \u00b1 0.16 to 3.4 \u00b1 2.1 ng\/ml. Three out of nine patients had testosterone levels below 3 ng\/ml.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our present study indicates that pubertal development can occur in patients presenting with hypogonadotropic hypogonadism after 18 years of age. However, acquired pubertal status may be subnormal<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/2230-8210.117245","type":"journal-article","created":{"date-parts":[[2013,8,29]],"date-time":"2013-08-29T01:48:18Z","timestamp":1377740898000},"page":"851-854","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Progression of puberty after initiation of androgen therapy in patients with idiopathic hypogonadotropic hypogonadism"],"prefix":"10.4103","volume":"17","author":[{"given":"Bindu","family":"Kulshreshtha","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Khadgawat","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandita","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariachery","family":"Ammini","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20260327","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1210\/jcem.87.1.8131","article-title":"The role of prior pubertal development, biochemical markers of testicular maturation, and genetics in elucidating the phenotypic heterogeneity of idiopathic hypogonadotropic hypogonadism","volume":"87","author":"Pitteloud","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl 2","key":"R2-20260327","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1515\/jpem-2001-s207","article-title":"International Workshop on Management of Puberty for Optimum Auxological Results. 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