{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:45:22Z","timestamp":1787071522245,"version":"build-2736575974"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Vitamin D (VitD) classically recognized for its role in the musculoskeletal system, has been implicated in myriad of conditions such as diabetes, immune dysfunction, cancers, heart disease, metabolic syndrome, etc. We studied the role of VitD in acute care setting and its correlation with mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A total of 85 consecutive consenting patients admitted in medical intensive care unit of tertiary care hospital who fulfilled the inclusion criteria were included. All patients were evaluated clinically, and blood samples were collected for hemogram, biochemical investigations including serum calcium, phosphorus, alkaline phosphatase, magnesium, along with 25(OH) VitD, 1,25(OH) VitD and intact parathormone levels. Simplified acute physiology score (SAPS II) was calculated for all patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      VitD was deficient (&lt;30 ng\/ml) in 27 patients (32%). The overall mortality was more in VitD deficient group as compared to VitD sufficient group (74 vs. 41%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05). The actual mortality in VitD deficient group was higher than the mortality predicted by SAPS II score (50 vs. 74%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.0507). VitD deficiency was also associated with more mortality among those requiring ventilator support (95% vs. 40%;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05) as well as with higher blood glucose (124.5 \u00b1 29.7 vs. 94.8 \u00b1 19.8:\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01) levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>VitD deficiency was associated with increased mortality, poor ventilator outcomes, and increased blood glucose in critically ill patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/2230-8210.137504","type":"journal-article","created":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T07:26:23Z","timestamp":1406100383000},"page":"511-515","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Vitamin D deficiency is associated with increased mortality in critically ill patients especially in those requiring ventilatory support"],"prefix":"10.4103","volume":"18","author":[{"given":"Ameya","family":"Joshi","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Topiwala National Medical College and BYL Nair Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Bhadade","sequence":"additional","affiliation":[{"name":"Department of Medicine, Topiwala National Medical College and BYL Nair Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Premlata K.","family":"Varthakavi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Topiwala National Medical College and BYL Nair Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosmarie","family":"DeSouza","sequence":"additional","affiliation":[{"name":"Department of Medicine, Topiwala National Medical College and BYL Nair Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil M.","family":"Bhagwat","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Topiwala National Medical College and BYL Nair Hospital, Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj D.","family":"Chadha","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Topiwala National Medical College and BYL Nair Hospital, 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