{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:44:59Z","timestamp":1787071499060,"version":"build-2736575974"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>To evaluate if hormonal profile of children with isolated hypospadias (IH) associates better with comprehensive local anatomical factor score (LAFS) than with clinically adjudged urethral meatus location or severity of chordee\/k.j.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods:<\/jats:title>\n                    <jats:p>Ninety-nine children with IH were enrolled, as per inclusion criteria. Meatal location was recorded at first clinical examination in OPD; while LAFS was computed per-operatively using indigenously devised scale, except for neonates. Hypospadiacs were first classified into three standard meatal based groups and subsequently into LAFS based two groups (\u226419, &gt;19). For all participants, pre HCG and post HCG (96 hour post- injection) estimation of serum gonadotropins, DHEA-S, estrogen (E), progesterone (P), testosterone (T) and Dihydrotestosterone (DHT) was done. Statistical tests were applied to assess significance of hormonal levels with respect to meatal location, chordee and LAFS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Only FSH levels differed significantly among meatal based groups; while among LAFS groups, multiple hormonal differences were noted; with poor LAFS associated significantly with higher FSH, LH and lower E, T\/DHT. Children with severe degree of chordee had poorer T output and a significantly lower LAFS as compared to those with moderate\/mild chordee.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Serotoli cell dysfunction, indirectly indicated by high FSH was found among midpenile hypospadiacs and those with poorer LAFS. Since groups based on LAFS revealed multiple intergroup hormonal differences than what was seen for meatal\/chordee based groups; LAFS should be considered a better guide for prognostication and for deciding about hormonal supplementation. Lower androgenic output was particularly noted in children with severe chordee.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/2230-8210.137519","type":"journal-article","created":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T07:26:23Z","timestamp":1406100383000},"page":"558-564","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Hormonal profile in children with isolated hypospadias associates better with comprehensive score of local anatomical factors as compared to meatal location or degree of chordee"],"prefix":"10.4103","volume":"18","author":[{"given":"Simmi K.","family":"Ratan","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Maulana Azad Medical College, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish K.","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Maulana Azad Medical College, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarun Kumar","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Maulana Azad Medical College, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alpna","family":"Saxena","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Maulana Azad Medical College, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeeta","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Maulana Azad Medical College, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra M.","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anju","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Maulana Azad Medical College, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Dhanwal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Maulana Azad Medical College, New Delhi, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20260327","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/j.juro.2010.12.070","article-title":"Analysis of risk factors for glans dehiscence after tubularized incised plate hypospadias repair","volume":"185","author":"Snodgrass","year":"2011","journal-title":"J Urol"},{"key":"R2-20260327","doi-asserted-by":"crossref","first-page":"241","DOI":"10.4103\/0970-1591.40622","article-title":"Acute postoperative complications of hypospadias repair","volume":"24","author":"Bhat","year":"2008","journal-title":"Indian J Urol"},{"key":"R3-20260327","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0022-5347(17)45730-2","article-title":"Gonadotropin and testosterone response in prepubertal boys with hypospadias","volume":"135","author":"Shima","year":"1986","journal-title":"J Urol"},{"key":"R4-20260327","first-page":"365","article-title":"Plasma testosterone in male puberty. II. hCG stimulation test in boys with hypospadia","volume":"90","author":"Knorr","year":"1979","journal-title":"Acta Endocrinol (Copenh)"},{"key":"R5-20260327","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0022-5347(17)49755-2","article-title":"Pituitary and gonadal function in prepubertal boys with hypospadias","volume":"132","author":"Nonomura","year":"1984","journal-title":"J Urol"},{"key":"R6-20260327","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1515\/jpem.2011.421","article-title":"Children with isolated hypospadias have different hormonal profile compared to those with associated anomalies","volume":"25","author":"Ratan","year":"2012","journal-title":"J Pediatr Endocrinol Metab"},{"key":"R7-20260327","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1289\/ehp.011091175","article-title":"Hypospadias and endocrine disruption: Is there a connection? Environ","volume":"109","author":"Baskin","year":"2001","journal-title":"Health Perspect"},{"key":"R12-20260327","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1016\/j.juro.2010.12.109","article-title":"Editorial comment on Analysis of risk factors for glans dehiscence after tubularized incised plate hypospadias repair","volume":"185","author":"Baskin","year":"2011","journal-title":"J Urol"},{"key":"R13-20260327","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S0022-5347(17)50360-2","article-title":"Endocrine studies in patients with advanced hypospadias","volume":"131","author":"Allen","year":"1984","journal-title":"J Urol"},{"key":"R14-20260327","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0022-5347(17)42014-3","article-title":"Androgen receptor levels and 5\u03b1-reductase activities in pre-pubertal skin and chordee tissue of boys with isolated hypospadias","volume":"140","author":"Gearhart","year":"1988","journal-title":"J Urol"},{"key":"R15-20260327","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1172\/JCI113930","article-title":"Intracellular and nuclear binding of [3H] dihydrotestosterone in cultured genital skin fibroblasts of patients with severe hypospadias","volume":"83","author":"Schweikert","year":"1989","journal-title":"J Clin Invest"},{"key":"R16-20260327","doi-asserted-by":"crossref","first-page":"4041","DOI":"10.1210\/jc.2005-0302","article-title":"Hypospadias in a cohort of 1072 Danish newborn boys: Prevalence and relationship to placental weight, anthropometrical measurements at birth, and reproductive hormone levels at three months of age","volume":"90","author":"Boisen","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"R17-20260327","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1210\/jc.2003-032098","article-title":"Lack of defects in androgen production in children with hypospadias","volume":"89","author":"Holmes","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"R18-20260327","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1210\/jcem-42-1-52","article-title":"Plasma androgen response to hCG stimulation in prepubertal boys with hypospadias and cryptorchidism","volume":"42","author":"Walsh","year":"1976","journal-title":"J Clin Endocrinol Metab"},{"key":"R19-20260327","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/S0022-5347(05)64733-7","article-title":"Endocrine screening in 32 consecutive patients with hypospadias","volume":"168","author":"Feyaerts","year":"2002","journal-title":"J Urol"},{"key":"R20-20260327","doi-asserted-by":"crossref","first-page":"6035","DOI":"10.1210\/jc.2005-1306","article-title":"Low risk of impaired testicular Sertoli and Leydig cell functions in boys with isolated hypospadias","volume":"90","author":"Rey","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"R21-20260327","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1742-1241.2001.tb10989.x","article-title":"Lesser evaluated determinants of fistula formation in children with hypospadias","volume":"55","author":"Ratan","year":"2001","journal-title":"Int J Clin Pract"},{"key":"R22-20260327","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.purol.2009.02.013","article-title":"Repair of hypospadias: The effect of urethral plate configuration on the outcome of Duplay-Snodgrass repair","volume":"19","author":"Mosharafa","year":"2009","journal-title":"[Article in French] Prog Urol"},{"key":"R23-20260327","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s00383-002-0717-3","article-title":"Use of parenteral testosterone prior to hypospadias surgery","volume":"19","author":"Luo","year":"2003","journal-title":"Pediatr Surg Int"},{"key":"R24-20260327","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1053\/jpsu.2003.50047","article-title":"Testosterone therapy in microphallic hypospadias: Topical or parenteral?","volume":"38","author":"Chalapathi","year":"2003","journal-title":"J Pediatr Surg"},{"key":"R25-20260327","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jpurol.2010.05.003","article-title":"Does androgen stimulation prior to hypospadias surgery increase the rate of healing complications: A preliminary report","volume":"7","author":"Gorduza","year":"2011","journal-title":"J Pediatr Urol"},{"key":"R27-20260327","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1126\/science.7010602","article-title":"The hormonal control of sexual development","volume":"211","author":"Wilson","year":"1981","journal-title":"Science"},{"key":"R30-20260327","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1210\/edrv.22.3.0431","article-title":"Estrogen and spermatogenesis","volume":"22","author":"O\u2019Donnell","year":"2001","journal-title":"Endocr Rev"},{"key":"R31-20260327","first-page":"8","article-title":"Sex Hormones and Wound Healing","volume":"18","author":"Oh","year":"2006","journal-title":"Wounds"},{"key":"R32-20260327","doi-asserted-by":"crossref","first-page":"23","DOI":"10.5489\/cuaj.521","article-title":"Long-term functional outcome and satisfaction of patients with hypospadias repaired in childhood","volume":"2","author":"Hoag","year":"2008","journal-title":"Can Urol Assoc J"}],"container-title":["Indian Journal of Endocrinology and Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/02223308-201418040-00023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:47:01Z","timestamp":1787068021000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/02223308-201418040-00023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014]]}},"URL":"https:\/\/doi.org\/10.4103\/2230-8210.137519","relation":{},"ISSN":["2230-8210","2230-9500"],"issn-type":[{"value":"2230-8210","type":"print"},{"value":"2230-9500","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7]]}}}