{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:26:36Z","timestamp":1786728396094,"version":"build-2736575974"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Primary hyperparathyroidism (PHPT) is characterized by inappropriately elevated serum parathyroid hormone (PTH) level despite elevated serum calcium. Insulin resistant is the basic pathophysiology, behind the higher prevalence of diabetes mellitus in patients with PHPT. However, the improvement in insulin resistance (IR) after curative parathyroidectomy (CPTX) has not been established yet, as the study results are conflicting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>In this prospective interventional study, ten patients with mild PHPT (Group 1) and another ten patients with moderate to severe PHPT (Group 2) were undergone CPTX. The IR was assessed by homeostasis model assessment-IR (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), fasting plasma glucose (FPG), and fasting serum insulin (FSI), before and 3 months after CPTX.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There was no significant change of FPG and FSI, before and after CPTX in Group 1 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.179 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.104) and Group 2 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.376 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.488). Before surgery, HOMA-IR was higher, and QUICKI was significantly lower, in both Group 1 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.058 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.009) and Group 2 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.023 and\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.005) as compared to published normal reference mean, with no significant difference between the groups. Three months after surgery HOMA-IR increased further and QUICKI remained unchanged as compared to baseline, in both Group 1 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.072 and 0.082) and Group 2 (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.54 and 0.56), but statistically insignificant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>IR remained unchanged after CPTX in mild as well as moderate to severe PHPT. Asymptomatic PHPT with abnormal IR should not be used as criteria for parathyroidectomy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/2230-8210.192916","type":"journal-article","created":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T03:57:33Z","timestamp":1477281453000},"page":"784-789","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":15,"title":["Effect of curative parathyroidectomy on insulin resistance"],"prefix":"10.4103","volume":"20","author":[{"given":"Rachel","family":"Putnam","sequence":"first","affiliation":[{"name":"Department of Endocrinology, HFHS, Detroit, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deba Prasad","family":"Dhibar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Varshney","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunanshu","family":"Behera","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. R.","family":"Mittal","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Bhansali","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudhaker D.","family":"Rao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, HFHS, Detroit, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay Kumar","family":"Bhadada","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Postgraduate Institute of Medical Education and Research, Chandigarh, 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