{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:26:13Z","timestamp":1792517173502,"version":"4.5.0"},"reference-count":42,"publisher":"Manuscript Technomedia LLP","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Pharma Investig"],"published-print":{"date-parts":[[2012]]},"DOI":"10.4103\/2230-973x.96922","type":"journal-article","created":{"date-parts":[[2012,6,4]],"date-time":"2012-06-04T15:20:34Z","timestamp":1338823234000},"page":"18","source":"Crossref","is-referenced-by-count":72,"title":["The effect of water on the solid state characteristics of pharmaceutical excipients: Molecular mechanisms, measurement techniques, and quality aspects of final dosage form"],"prefix":"10.5530","volume":"2","author":[{"given":"Rom\u00e1na","family":"Zelk\u00f3","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gergely","family":"Szakonyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"3478","reference":[{"key":"key-10.4103\/2230-973X.96922-1","first-page":"105","volume-title":"A review on methods and theories to describe the glass transition phenomenon: Applications in food and pharmaceutical products","author":"Abiad","year":"2009","journal-title":"Food Eng Rev"},{"key":"key-10.4103\/2230-973X.96922-2","first-page":"1","volume-title":"Characteristics and significance of the amorphous state in pharmaceutical systems","author":"Hancock","year":"1997","journal-title":"J Pharm Sci"},{"key":"key-10.4103\/2230-973X.96922-3","first-page":"27","volume-title":"Amorphous pharmaceutical solids: Preparation, characterization and stabilization","author":"Yu","year":"2001","journal-title":"Adv Drug Deliver Rev"},{"key":"key-10.4103\/2230-973X.96922-4","first-page":"179","volume-title":"The relevance of the amorphous state to pharmaceutical dosage forms: Glassy drugs and freeze dried systems","author":"Craig","year":"1999","journal-title":"Int J Pharm"},{"key":"key-10.4103\/2230-973X.96922-5","first-page":"82","volume-title":"Glass transition temperature: Basics and application in pharmaceutical sector","author":"Jadhav","year":"2009","journal-title":"Asian J Pharm","ISSN":"https:\/\/id.crossref.org\/issn\/0973-8398","issn-type":"print"},{"key":"key-10.4103\/2230-973X.96922-6","first-page":"2195","volume-title":"FTIR study of state and phase transitions of low moisture sucrose and lactose","author":"Ottenhof","year":"2003","journal-title":"Carbohyd Res"},{"key":"key-10.4103\/2230-973X.96922-7","first-page":"1371","volume-title":"Water absorption and states of water in semicrystalline poly(vinyl alcohol) films","author":"Hodge","year":"1996","journal-title":"Polymer"},{"key":"key-10.4103\/2230-973X.96922-8","first-page":"8461","volume-title":"States of water in different hydrophilic polymers - DSC and FTIR studies","author":"Ping","year":"2001","journal-title":"Polymer"},{"key":"key-10.4103\/2230-973X.96922-9","first-page":"345","volume-title":"Water vapour sorption by pharmaceutical sugars","author":"Hancock","year":"1998","journal-title":"Pharm Sci Technol Today"},{"key":"key-10.4103\/2230-973X.96922-10","first-page":"1255","volume-title":"Direct visualization of superdisintegrant hydration using environmental scanning electron microscopy","author":"Thibert","year":"1996","journal-title":"J Pharm Sci"},{"key":"key-10.4103\/2230-973X.96922-11","first-page":"960","volume-title":"Correlations between molecular mobility and chemical stability during storage of amorphous pharmaceuticals","author":"Yoshioka","year":"2007","journal-title":"J Pharm Sci"},{"key":"key-10.4103\/2230-973X.96922-12","first-page":"244","volume-title":"Humidity-induced plasticization and antiplasticization of polyamide 6: A Positron lifetime study of the local free volume","author":"Dlubek","year":"2002","journal-title":"J Appl Polym Sci"},{"key":"key-10.4103\/2230-973X.96922-13","first-page":"1647","volume-title":"Determination of glass transition temperature and in situ study of the plasticizing effect of water by inverse gas chromatography","author":"Surana","year":"2003","journal-title":"Pharm Res"},{"key":"key-10.4103\/2230-973X.96922-14","first-page":"3943","volume-title":"What causes the unfrozen water in polymers: Hydrogen bonds between water and polymer chains?","author":"Liu","year":"2001","journal-title":"Polymer"},{"key":"key-10.4103\/2230-973X.96922-15","first-page":"24","volume-title":"State of water in starch-water systems in the gelatinization temperature range as investigated using dielectric relaxation spectroscopy","author":"Motwania","year":"2012","journal-title":"Carbohyd Polym"},{"key":"key-10.4103\/2230-973X.96922-16","first-page":"43","volume-title":"Characterization of the molecular state of water present in pharmaceutical additives by NIR spectroscopy","author":"Ohtake","year":"2006","journal-title":"Asian J Pharm Sci"},{"key":"key-10.4103\/2230-973X.96922-17","first-page":"9","volume-title":"Effects of water vapor absorption on the physical and chemical stability of amorphous sodium indomethacin","author":"Tong","year":"2004","journal-title":"AAPS PharmSciTech"},{"key":"key-10.4103\/2230-973X.96922-18","first-page":"187","volume-title":"The interactions of water with cellulose- and starch-derived pharmaceutical excipients","author":"Zografi","year":"1986","journal-title":"Pharm Res"},{"key":"key-10.4103\/2230-973X.96922-19","first-page":"1063","volume-title":"The Relationship between \"BET\"- and \"Free Volume\"-derived parameters for water vapor absorption into amorphous solids","author":"Zhang","year":"2000","journal-title":"J Pharm Sci"},{"key":"key-10.4103\/2230-973X.96922-20","first-page":"1390","volume-title":"Determining the water sorption monolayer of lyophilized pharmaceutical proteins","author":"Costantino","year":"1997","journal-title":"J Pharm Sci"},{"key":"key-10.4103\/2230-973X.96922-21","first-page":"1445","volume-title":"Effect of sorbitol and residual moisture on the stability of lyophilized antibodies: Implications for the mechanism of protein stabilization in the solid state","author":"Chang","year":"2005","journal-title":"J Pharm Sci"},{"key":"key-10.4103\/2230-973X.96922-22","first-page":"235","volume-title":"Multilayer sorption parameters: BET or GAB values.Colloid Surface A?","author":"Timmermann","year":"2003","journal-title":""},{"key":"key-10.4103\/2230-973X.96922-23","first-page":"662","volume-title":"Evaluation of the moisture sorption behaviour of several excipients by BET, GAB and microcalorimetric approaches","author":"Ro\u0161kar","year":"2005","journal-title":"Chem Pharm Bull"},{"key":"key-10.4103\/2230-973X.96922-24","first-page":"45","volume-title":"Solute retention and the states of water in polyethylene glycol and poly(vinyl alcohol) gels","author":"Baba","year":"2004","journal-title":"J Chromatogr A"},{"key":"key-10.4103\/2230-973X.96922-25","first-page":"467","volume-title":"Importance of bound water in hydration-dehydration behaviour of hydroxylated poly(N-isopropylacrylamide)","author":"Maeda","year":"2006","journal-title":"J Colloid Interf Sci"},{"key":"key-10.4103\/2230-973X.96922-26","first-page":"1462","volume-title":"States of water in Poly(vinyl alcohol) derivative hydrogels","author":"Ruiz","year":"2003","journal-title":"J Polym Sci Pol Phys"},{"key":"key-10.4103\/2230-973X.96922-27","first-page":"681","volume-title":"The investigation on states of water in different hydrophilic polymers by DSC and FTIR","author":"Guan","year":"2010","journal-title":"J Polym Res"},{"key":"key-10.4103\/2230-973X.96922-28","doi-asserted-by":"crossref","unstructured":"Haxaire K, Mar\u00e9chal Y, Milas M, Rinaudo M. Hydration of polysaccharide hyaluronan observed by IR Spectrometry. I. Preliminary experiments and band assignments. Biopolymers 2003;72:10-20.","DOI":"10.1002\/bip.10245"},{"key":"key-10.4103\/2230-973X.96922-29","first-page":"3121","volume-title":"FTIR study on the nature of water sorbed in polypropylene (PP)\/ethylene alcohol vinyl (EVOH) films","author":"Lasagabaster","year":"2006","journal-title":"Eur Polym J"},{"key":"key-10.4103\/2230-973X.96922-30","first-page":"27","volume-title":"Observing the water molecule in macromolecules and aqueous media using infrared spectrometry","author":"Mar\u00e9chal","year":"2003","journal-title":"J Mol Struct"},{"key":"key-10.4103\/2230-973X.96922-31","first-page":"6431","volume-title":"A novel spectroscopic approach to investigate transport processes in polymers: The case of water-epoxy system","author":"Cotugno","year":"2001","journal-title":"Polymer"},{"key":"key-10.4103\/2230-973X.96922-32","first-page":"813","volume-title":"The association of water to cellulose and hemicellulose in paper examined by FTIR spectroscopy.CarbohyDr","author":"Olsson","year":"2004","journal-title":"Res"},{"key":"key-10.4103\/2230-973X.96922-33","first-page":"1137","volume-title":"How does residual water affect the solid-state degradation of drugs in the amorphous state?","author":"Shalaev","year":"1996","journal-title":"J Pharm Sci"},{"key":"key-10.4103\/2230-973X.96922-34","doi-asserted-by":"crossref","unstructured":"Lai MC, Hageman MJ, Schowen RL, Borchardt RT, Laird BB, Topp EM. Chemical stability of peptides in polymers. 2. Discriminating between solvent and plasticizing effects of water on peptide deamidation in poly(vinylpyrrolidone). J Pharm Sci 1999;88:1081-9.","DOI":"10.1021\/js9802289"},{"key":"key-10.4103\/2230-973X.96922-35","first-page":"1908","volume-title":"Effects of drying process for amorphous waxy maize starch on theophylline release from starch-based tablets","author":"Yoon","year":"2007","journal-title":"J Appl Polym Sci"},{"key":"key-10.4103\/2230-973X.96922-36","first-page":"220","volume-title":"Influence of cellulose powder structure on moisture-induced degradation of acetylsalicylic acid","author":"Mihranyana","year":"2006","journal-title":"Eur J Pharm Sci"},{"key":"key-10.4103\/2230-973X.96922-37","first-page":"245","volume-title":"Plasticisation of amylodextrin by moisture.Consequences for compaction behaviour and tablet properties","author":"Steendam","year":"2001","journal-title":"Eur J Pharm Sci"},{"key":"key-10.4103\/2230-973X.96922-38","first-page":"351","volume-title":"Correlation between the release characteristics of theophylline and the free volume of polyvinylpyrrolidone","author":"Zelk\u00f3","year":"2005","journal-title":"Eur J Pharm Sci"},{"key":"key-10.4103\/2230-973X.96922-39","first-page":"730","volume-title":"Prediction of the drug release stability of different polymeric matrix tablets containing metronidazole","author":"Szente","year":"2011","journal-title":"J Pharm Biomed Anal"},{"key":"key-10.4103\/2230-973X.96922-40","first-page":"795","volume-title":"Physical aging of poly(vinylpyrrolidone) under different humidity conditions","author":"S\u00fcvegh","year":"2002","journal-title":"Macromolecules"},{"key":"key-10.4103\/2230-973X.96922-41","first-page":"249","volume-title":"Tracking of the physical ageing of amorphous pharmaceutical polymeric excipients by positron annihilation spectroscopy","author":"Zelk\u00f3","year":"2006","journal-title":"J Pharm Biomed Anal"},{"key":"key-10.4103\/2230-973X.96922-42","first-page":"768","volume-title":"Effect of spray drying and subsequent processing conditions on residual moisture content and physical\/biochemical stability of protein inhalation powders","author":"Maa","year":"1998","journal-title":"Pharm Res"}],"container-title":["International Journal of Pharmaceutical Investigation"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T09:09:56Z","timestamp":1771578596000},"score":1,"resource":{"primary":{"URL":"https:\/\/jpionline.org\/article\/2\/1\/18"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012]]}},"alternative-id":["96922"],"URL":"https:\/\/doi.org\/10.4103\/2230-973x.96922","relation":{},"ISSN":["2230-973X"],"issn-type":[{"value":"2230-973X","type":"print"}],"subject":[],"published":{"date-parts":[[2012]]}}}