{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T16:02:10Z","timestamp":1786636930402,"version":"build-2736575974"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Maxillofac Surg"],"published-print":{"date-parts":[[2012]]},"DOI":"10.4103\/2231-0746.101334","type":"journal-article","created":{"date-parts":[[2012,9,25]],"date-time":"2012-09-25T13:51:12Z","timestamp":1348581072000},"page":"121","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of 22q11.2 deletion in Cleft Palate patients"],"prefix":"10.4103","volume":"2","author":[{"given":"LB","family":"Lahiru Prabodha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DayanathKumara","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BGanananda","family":"Nanayakkara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DeepthiC","family":"de Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"NVishvanath","family":"Chandrasekharan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isurani","family":"Ileyperuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/2231-0746.101334-1","unstructured":"Sadler TW. Langman\u2032s Medical Embryology. 10 th ed. USA: Lippincott, Williams & Wilkins; 2006."},{"key":"key-10.4103\/2231-0746.101334-2","first-page":"11","volume-title":"Management of children with cleft lip and palate: A review describing the application of multidisciplinary team working in this condition based upon the experiences of a regional cleft lip and palate centre in the United Kingdom","author":"Hodgkinson","year":"2005","journal-title":"Fetal Matern Med Rev"},{"key":"key-10.4103\/2231-0746.101334-3","unstructured":"Sperber GH. Craniofacial Embryology. 4 th ed.USA: PSG Publishing Co; 1989."},{"key":"key-10.4103\/2231-0746.101334-4","first-page":"2421","volume-title":"The 22q11 deletion syndrome.Hum Mol Genet","author":"Scambler","year":"2000","journal-title":""},{"key":"key-10.4103\/2231-0746.101334-5","unstructured":"Biavati MJ, Rocha-Worley G. E - Medicine from web MD: Palatopharyngeal Incompetence, Nov. 2006. Available at: http: \/\/emedicine.medscape.com\/article\/994975-overview#showall (Accessed on 28 th March 2011)"},{"key":"key-10.4103\/2231-0746.101334-6","first-page":"533","volume-title":"Seasonal variation and regional distribution of cleft lip and palate in Zambia","author":"Elliott","year":"2008","journal-title":"Cleft Palate Craniofac J"},{"key":"key-10.4103\/2231-0746.101334-7","first-page":"185","volume-title":"An epidemiologic study of isolated cleft lip, palate, or both in Victoria, Australia from 1983 to 2000","author":"Vallino-Napoli","year":"2004","journal-title":"Cleft Palate Craniofac J"},{"key":"key-10.4103\/2231-0746.101334-8","first-page":"126","volume-title":"Prevalence of nonsyndromic oral clefts in Texas: 1995-1999","author":"Tolarova","year":"1998","journal-title":"Am J Med Genet"},{"key":"key-10.4103\/2231-0746.101334-9","first-page":"559","volume-title":"Incidence of cleft lip and palate in Sri Lanka","author":"Amaratunga","year":"1989","journal-title":"J Oral Maxillofac Surg"},{"key":"key-10.4103\/2231-0746.101334-10","first-page":"22","volume-title":"Genetic and non-genetic factors in the etiology of facial clefts","author":"Fogh-Andersen","year":"1967","journal-title":"Scand J Plast Reconstr Surg"},{"key":"key-10.4103\/2231-0746.101334-11","first-page":"197","volume-title":"Cleft lip and palate in Finland in 1948-75: Correlations to infections, seasonal and yearly variations","author":"Rintala","year":"1983","journal-title":"Scand J Plast Reconstr Surg"},{"key":"key-10.4103\/2231-0746.101334-12","unstructured":"Stricker M, Vander J, Raphael B. Classification of Craniofacial Malformation. In: Textbook of Craniofacial Malformation.1 st ed. Edinburgh: Churchill Livingston;1990.p. 149-287."},{"key":"key-10.4103\/2231-0746.101334-13","first-page":"595","volume-title":"Prevalence and clinical manifestations of 22q11.2 microdeletion in adults with selected conotruncal anomalies","author":"Beauchesne","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"key-10.4103\/2231-0746.101334-14","first-page":"417","volume-title":"Aberrant interchromasomal exchanges are the predominant cause of the 22q11.2 deletion","author":"Saitta","year":"2004","journal-title":"Hum Mol Genet"},{"key":"key-10.4103\/2231-0746.101334-15","unstructured":"E-notes.com. LLC. Encyclopedia of Genetic Disorders: Deletion 22q11 Syndrome. Available at: http:\/\/www.enotes.com\/deletion-22q11-syndrome-reference\/deletion-22q11-syndrome. (Accessed on 28 th March 2011)"},{"key":"key-10.4103\/2231-0746.101334-16","first-page":"101","volume-title":"A population-based study of the 22q11.2 deletion: Phenotype, incidence, and contribution to major birth defects in the population","author":"Botto","year":"2003","journal-title":"Pediatrics"},{"key":"key-10.4103\/2231-0746.101334-17","first-page":"953","volume-title":"Integration of cytogenetic marks into the draft sequence of the human genome","author":"Cheung","year":"2001","journal-title":"Nature"},{"key":"key-10.4103\/2231-0746.101334-18","first-page":"1003","volume-title":"Recent segmental duplications in the human genome","author":"Bailey","year":"2002","journal-title":"Science"},{"key":"key-10.4103\/2231-0746.101334-19","first-page":"813","volume-title":"Prevalence of 22q11 microdeletions in DiGeorge and velocardiofacial syndromes: Implications for genetic counselling and prenatal diagnosis","author":"Driscoll","year":"1993","journal-title":"J Med Genet"},{"key":"key-10.4103\/2231-0746.101334-20","first-page":"308","volume-title":"Confirmation that the velocardio-facial syndrome is associated with haplo-insufficiency of genes at chromosome 22q11","author":"Kelly","year":"1993","journal-title":"Am J Med Genet"},{"key":"key-10.4103\/2231-0746.101334-21","first-page":"74","volume-title":"Genome architecture, rearrangements and genomic disorders","author":"Stankiewicz","year":"2002","journal-title":"Trends Genet"},{"key":"key-10.4103\/2231-0746.101334-22","first-page":"513","volume-title":"Towards earlier diagnosis of 22q11 deletion","author":"Tobias","year":"1999","journal-title":"Arch Dis Child"},{"key":"key-10.4103\/2231-0746.101334-23","first-page":"18","volume-title":"Breakpoint associated with a novel 2.3 Mb deletion in the VCFS region of 22q11 and the role of Alu (SINE) in recurring microdeletions","author":"Uddin","year":"2006","journal-title":"BMC Med Genet"},{"key":"key-10.4103\/2231-0746.101334-24","doi-asserted-by":"crossref","unstructured":"Rolfs A, Schuller I, Finckh U, Weber-Rolfsw I. PCR: Principles and reaction components in PCR. In: Rolfs A, Schuller I, Finckh U, Weber-Rolfsw I, editors. Clinical Diagnostics and Research. Berlin: Springer-Verlag; 1992. p. 1-16.","DOI":"10.1007\/978-3-642-77492-8_1"},{"key":"key-10.4103\/2231-0746.101334-25","first-page":"7","volume-title":"Epidemiology of cleft lip and palate in Thailand","author":"Chuangsuwanich","year":"1998","journal-title":"Ann Plast Surg"},{"key":"key-10.4103\/2231-0746.101334-26","first-page":"1695","volume-title":"Survey of the patients with cleft lip and palate in China who were funded for surgery by the Smile Train Program from2000 to 2002","author":"Zhou","year":"2006","journal-title":"Chin Med J (Engl)"},{"key":"key-10.4103\/2231-0746.101334-27","first-page":"717","volume-title":"Epidemiology of facial clefts","author":"Womersley","year":"1987","journal-title":"Arch Dis Child"},{"key":"key-10.4103\/2231-0746.101334-28","first-page":"609","volume-title":"Cleft Lip and Palate in Jordan: Birth Prevalence Rate","author":"Al-Omari","year":"2004","journal-title":"Cleft Palate Craniofac J"},{"key":"key-10.4103\/2231-0746.101334-29","first-page":"105","volume-title":"Epidemiologic factors causing cleft lip and palate and their regularities of occurrence in Estonia","author":"Jagomagi","year":"2010","journal-title":"Stomatologija"},{"key":"key-10.4103\/2231-0746.101334-30","first-page":"179","volume-title":"Sex-linked inheritance of cleft palate","author":"Rushton","year":"1979","journal-title":"Hum Genet"},{"key":"key-10.4103\/2231-0746.101334-31","first-page":"107","volume-title":"Maternal and paternal age, birth order and interpregnancy interval evaluation for cleft lip and palate","author":"Martelli","year":"2010","journal-title":"Braz J Otorhinolaryngol"},{"key":"key-10.4103\/2231-0746.101334-32","first-page":"191","volume-title":"An epidemiologic study of oral clefts in Iran: Analysis of 1,669 cases","author":"Rajabian","year":"2000","journal-title":"Cleft Palate Craniofac J"},{"key":"key-10.4103\/2231-0746.101334-33","unstructured":"Krumova V. Clinical and Genetic Peculiarities of Isolated Cleft Palates. J IMAB 2008;14:52-4. Available from: http:\/\/www.journal-imab-bg.org\/statii-08\/vol08_2_52-54str.pdf. [Last Accessed on 2011 Dec 12]."},{"key":"key-10.4103\/2231-0746.101334-34","first-page":"59","volume-title":"A study of cleft lip and palate in neonates born in a large Malaysian maternity hospital over a 2-year period","author":"Boo","year":"1990","journal-title":"Singapore Med J"},{"key":"key-10.4103\/2231-0746.101334-35","first-page":"126","volume-title":"Facial clefts in the west of Scotland in the period 1980-1984: Epidemiology and genetic diagnoses","author":"FitzPatrick","year":"1994","journal-title":"J Med Genet"},{"key":"key-10.4103\/2231-0746.101334-36","first-page":"258","volume-title":"Cleft lip and palate in Denmark, 1976-1981: Epidemiology, variability and early somatic development","author":"Jensen","year":"1988","journal-title":"Cleft Palate J"},{"key":"key-10.4103\/2231-0746.101334-37","first-page":"216","volume-title":"No justification of routine screening for 22q11 deletions in patients with overt cleft palate","author":"Ruiter","year":"2003","journal-title":"Clin Genet"},{"key":"key-10.4103\/2231-0746.101334-38","first-page":"14","volume-title":"Prenatal diagnosis of the 22q11.2 deletion syndrome","author":"Driscoll","year":"2001","journal-title":"Genet Med"}],"container-title":["Annals of Maxillofacial Surgery"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T15:03:17Z","timestamp":1786633397000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/2231-0746.101334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012]]}},"alternative-id":["101334"],"URL":"https:\/\/doi.org\/10.4103\/2231-0746.101334","relation":{},"ISSN":["2231-0746"],"issn-type":[{"value":"2231-0746","type":"print"}],"subject":[],"published":{"date-parts":[[2012]]}}}