{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T08:40:55Z","timestamp":1770280855167,"version":"3.49.0"},"reference-count":0,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"vor","delay-in-days":3417,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Avicenna J Med"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objectives: To describe the epidemiologic characteristics, clinical features, and outcome of severe cases of 2009 H1N1 influenza A infections who were admitted to the intensive care units (ICUs) in Damascus, Syria. Materials and Methods: Retrospectively, we collected clinical data on all patients who were admitted to the ICU with confirmed or suspected diagnosis of severe 2009 H1N1 influenza A with respiratory failure at 4 major tertiary care hospitals in Damascus, Syria. Acute Physiology and Chronic Health Evaluation (APACHE) II system was used to assess the severity of illness within the first 24 h after admission. The outcome was overall hospital mortality. Results: Eighty patients were admitted to the ICU with severe 2009 H1N1 infection. The mean age was 40.7 years; 69.8% of patients had \u22651 of the risk factors: asthmatics 20%, obesity 23.8%, and pregnancy 5%; and 72.5% had acute lung injury or adult respiratory distress syndrome, 12.5% had viral pneumonia, 42.5% had secondary bacterial pneumonia, and 15% had exacerbation of airflow disease. Mechanical ventilation was required in 73.7% of cases. The mean hospital length of stay was 11.7 days (median 8 days, range 0-77 days, IQR: 5-14 days). The overall mortality rate was 51% for a mean APACHE II score of 15.2 with a predicted mortality of 21% (standardized mortality ratio of 2.4, 95% confidence interval: 1.7-3.2, P value &lt; 0.001). Conclusion: Critically ill patients with severe 2009 H1N1 infection in this limited resource country had a much higher mortality rate than the predicted APACHE II mortality rate or when compared with the reported mortality rates for severe cases in other countries during 2009 H1N1 pandemic.<\/jats:p>","DOI":"10.4103\/2231-0770.99156","type":"journal-article","created":{"date-parts":[[2012,7,28]],"date-time":"2012-07-28T13:35:09Z","timestamp":1343482509000},"page":"34-37","source":"Crossref","is-referenced-by-count":6,"title":["Characteristics and outcome of critically ill patients with 2009 H1N1 influenza infection in Syria"],"prefix":"10.1055","volume":"02","author":[{"given":"Reem","family":"Alsadat","sequence":"additional","affiliation":[{"name":"Emergency Services, Al-Mouassat University Hospital, Damascus, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulrahman","family":"Dakak","sequence":"additional","affiliation":[{"name":"Pulmonary Department, Ibn Alnafees Hospital, Damscus,Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mouna","family":"Mazlooms","sequence":"additional","affiliation":[{"name":"Critical Care Medicine Department, Damascus Hospital, Damascus, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghasan","family":"Ghadhban","sequence":"additional","affiliation":[{"name":"Pulmonary Department, Assad University Hospital, Damascus, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shadi","family":"Fattoom","sequence":"additional","affiliation":[{"name":"Pulmonary Department, Assad University Hospital, Damascus, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Betelmal","sequence":"additional","affiliation":[{"name":"Word Health Organization, Damascus, Syria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nabil","family":"Abouchala","sequence":"additional","affiliation":[{"name":"Adult Critical Care Department, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mazen","family":"Kherallah","sequence":"additional","affiliation":[{"name":"Adult Critical Care Department, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2021,8,9]]},"container-title":["Avicenna Journal of Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/2231-0770.99156.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T23:10:09Z","timestamp":1628550609000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.4103\/2231-0770.99156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2021,8,9]]},"published-print":{"date-parts":[[2012,4]]}},"URL":"https:\/\/doi.org\/10.4103\/2231-0770.99156","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2231-0770","2249-4464"],"issn-type":[{"value":"2231-0770","type":"print"},{"value":"2249-4464","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}