{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:25:19Z","timestamp":1787775919404,"version":"build-2784847793"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Perinatal asphyxia is a major cause of neurological morbidity and mortality in India. The purpose of this study was to investigate variations in nucleated red blood cell (NRBC) in blood associated with perinatal asphyxia and its relationship to both the severity and short term prognosis of asphyxia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A prospective (case-control) study was undertaken at Gandhi Medical College and Associated Hospitals. A total of 100 neonates were included in the study. Levels of NRBC\/100 white blood cells (WBC) and absolute NRBC counts in cord blood were compared for 50 asphyxiated (case group) and 50 normal neonates (control group). These parameters were also related to the severity of asphyxia and clinical outcome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The number of NRBC\/100 WBC in the blood of 50 newborns each in the asphyxiated and in the control group were mean 29.5 \u00b1 26.0, range 7-144 NRBCs\/100 WBC and mean \u00b1 standard deviation 5.9 \u00b1 2.6, range 3-14 NRBCs\/100 WBC respectively (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01). Using quartile deviation, staging of hypoxic ischemic encephalopathy (HIE) was done on basis of NRBC count and there was 80% agreement between clinical and NRBC staging of HIE. There was a significant (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.01) correlation of the number of NRBC\\100 WBC with Apgar scoring, HIE staging and mortality.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The NRBCs\/100 WBCs can be used as a simple marker for the assessment of severity and early outcome of perinatal asphyxia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/2249-4847.123097","type":"journal-article","created":{"date-parts":[[2013,12,16]],"date-time":"2013-12-16T02:17:08Z","timestamp":1387160228000},"page":"179-182","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":25,"title":["Nucleated Red Blood Cell in Cord Blood as a Marker of Perinatal Asphyxia"],"prefix":"10.4103","volume":"2","author":[{"given":"Manjusha","family":"Goel","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Gandhi Medical College, Bhopal, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Dwivedi","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Gandhi Medical College, Bhopal, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poorva","family":"Gohiya","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Gandhi Medical College, Bhopal, Madhya Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deeparaj","family":"Hegde","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Lokmanya Tilak Municipal Medical College, Sion (West), Mumbai, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-20250521","doi-asserted-by":"crossref","first-page":"F211","DOI":"10.1136\/fn.84.3.F211","article-title":"Nucleated red blood cells in the fetus and newborn","volume":"84","author":"Hermansen","year":"2001","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"R3-20250521","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1213\/00000539-195301000-00041","article-title":"A proposal for a new method of evaluation of the newborn infant","volume":"32","author":"Apgar","year":"1953","journal-title":"Curr Res Anesth Analg"},{"key":"R4-20250521","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1001\/archneur.1976.00500100030012","article-title":"Neonatal encephalopathy following fetal distress","volume":"33","author":"Sarnat","year":"1976","journal-title":"A clinical and electroencephalographic study. Arch Neurol"},{"key":"R5-20250521","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1203\/00006450-198810000-00015","article-title":"Cord plasma vasopressin, erythropoietin, and hypoxanthine as indices of asphyxia at birth","volume":"24","author":"Ruth","year":"1988","journal-title":"Pediatr Res"},{"key":"R6-20250521","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1016\/0002-9378(95)90620-7","article-title":"Nucleated red blood cells: A marker for fetal asphyxia?","volume":"173","author":"Phelan","year":"1995","journal-title":"Am J Obstet Gynecol"},{"key":"R7-20250521","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0022-3476(05)81662-2","article-title":"Nucleated erythrocytes in healthy infants and in infants of diabetic mothers","volume":"116","author":"Green","year":"1990","journal-title":"J Pediatr"},{"key":"R8-20250521","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/sj.jp.7211437","article-title":"Umbilical cord nucleated red blood cell counts: Normal values and the effect of labor","volume":"26","author":"McCarthy","year":"2006","journal-title":"J Perinatol"},{"key":"R9-20250521","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/S0002-9378(96)80010-X","article-title":"Nucleated red blood cells: An update on the marker for fetal asphyxia","volume":"175","author":"Korst","year":"1996","journal-title":"Am J Obstet Gynecol"},{"key":"R10-20250521","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1479-828X.2000.tb03336.x","article-title":"Haematopoietic indicators of fetal metabolic acidosis","volume":"40","author":"Spencer","year":"2000","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"R11-20250521","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/S0002-9378(99)70396-0","article-title":"Nucleated red blood cell count at birth as an index of perinatal brain damage","volume":"181","author":"Buonocore","year":"1999","journal-title":"Am J Obstet Gynecol"}],"container-title":["Journal of Clinical Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01673464-201302040-00008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:46:22Z","timestamp":1787773582000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01673464-201302040-00008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2013]]}},"URL":"https:\/\/doi.org\/10.4103\/2249-4847.123097","relation":{},"ISSN":["2249-4847","1658-6093"],"issn-type":[{"value":"2249-4847","type":"print"},{"value":"1658-6093","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10]]}}}