{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T20:27:09Z","timestamp":1786739229815,"version":"build-2736575974"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,1]]},"abstract":"\n Background:<\/jats:title>\n The Study aimed to compare the effectiveness of two commonly used conservative treatments, splinting and local steroid injection in improving clinical and nerve conduction findings of the patients with severe carpal tunnel syndrome (CTS).<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n In this randomized control clinical trial, the patients with severe CTS selected and randomized in two interventional groups. Group A was prescribed to use full time neutral wrist splint and group B was injected with 40 mg Depo-Medrol and prescribed to use the full time neutral wrist splint for 12 weeks. Clinical and nerve conduction findings of the patients was evaluated at baseline, 4 and 12 weeks after interventions.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Twenty-two and 21 patients were allocated in group A and B, respectively. Mean of clinical symptoms and functional status scores, nerve conduction variables and patients\u2019 satisfaction score were not significant between group at baseline and 4 and 12 weeks after intervention. Within the group comparison, there was significant improvement in the patients\u2019 satisfaction, clinical and nerve conduction items between the baseline level and 4 weeks after intervention and between the baseline and 12 weeks after intervention (\n P<\/jats:italic>\n < 0.01). The difference was significant for functional status score between 4 and 12 weeks after intervention in group B (\n P<\/jats:italic>\n = 0.02).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n considering some findings regarding the superior effect of splinting plus local steroid injection on functional status scale and median nerve distal motor latency, it seems that using combination therapy could be more effective for long-term period specially in the field of functional improvement of CTS.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/2277-9175.175902","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T01:49:15Z","timestamp":1454896155000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":8,"title":["Effectiveness of splinting and splinting plus local steroid injection in severe carpal tunnel syndrome: A Randomized control clinical trial"],"prefix":"10.4103","volume":"5","author":[{"given":"Saeid","family":"Khosrawi","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Emadi","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Ebrahim","family":"Mahmoodian","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2016,2,8]]},"reference":[{"key":"R2-20251008","doi-asserted-by":"crossref","first-page":"623","DOI":"10.4103\/0972-2327.120495","article-title":"A study of interpolation method in diagnosis of carpal tunnel syndrome","volume":"16","author":"Ashraf","year":"2013","journal-title":"Ann Indian Acad Neurol"},{"key":"R3-20251008","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1212\/WNL.58.2.289","article-title":"Carpal tunnel syndrome incidence in a general population","volume":"58","author":"Mondelli","year":"2002","journal-title":"Neurology"},{"key":"R4-20251008","first-page":"6","article-title":"Carpal tunnel syndrome","volume":"77","author":"Aroori","year":"2008","journal-title":"Ulster Med J"},{"key":"R5-20251008","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2174\/1874325001206010069","article-title":"Carpal tunnel syndrome: A review of the recent literature","volume":"6","author":"Ibrahim","year":"2012","journal-title":"Open Orthop J"},{"key":"R6-20251008","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0363-5023(03)00148-5","article-title":"Severe carpal tunnel syndrome potentially needing surgical treatment in a general population","volume":"28","author":"Atroshi","year":"2003","journal-title":"J Hand Surg Am"},{"key":"R7-20251008","first-page":"4","article-title":"Pathophysiology of carpal tunnel syndrome","volume":"20","author":"Aboonq","year":"2015","journal-title":"Neurosciences (Riyadh)"},{"key":"R8-20251008","first-page":"2884","article-title":"Disabling injuries following carpal tunnel syndrome surgery","volume":"104","author":"Ahlberg","year":"2007","journal-title":"Lakartidningen"},{"key":"R9-20251008","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.arthro.2006.05.008","article-title":"Complications of endoscopic and open carpal tunnel release","volume":"22","author":"Benson","year":"2006","journal-title":"Arthroscopy"},{"key":"R10-20251008","first-page":"CD003219","article-title":"Non-surgical treatment (other than steroid injection) for carpal tunnel syndrome","volume":"1","author":"O\u2019Connor","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"R11-20251008","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2217\/ijr.09.63","article-title":"Current options for nonsurgical management of carpal tunnel syndrome","volume":"5","author":"Carlson","year":"2010","journal-title":"Int J Clin Rheumtol"},{"key":"R12-20251008","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1177\/0269215507077294","article-title":"A systematic review of conservative treatment of carpal tunnel syndrome","volume":"21","author":"Piazzini","year":"2007","journal-title":"Clin Rehabil"},{"key":"R13-20251008","first-page":"1","article-title":"Acupuncture in treatment of carpal tunnel syndrome: A randomized controlled trial study","volume":"17","author":"Khosrawi","year":"2012","journal-title":"J Res Med Sci"},{"key":"R14-20251008","doi-asserted-by":"crossref","first-page":"389","DOI":"10.5435\/00124635-200906000-00007","article-title":"Diagnosis of carpal tunnel syndrome","volume":"17","author":"Keith","year":"2009","journal-title":"J Am Acad Orthop Surg"},{"key":"R15-20251008","first-page":"46","article-title":"Outcome measurement questionnaires for carpal tunnel syndrome","volume":"3","author":"Afshar","year":"2005","journal-title":"Iran Orthop Surg"},{"key":"R16-20251008","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1749-799X-6-17","article-title":"Is surgical intervention more effective than non-surgical treatment for carpal tunnel syndrome? A systematic review","volume":"6","author":"Shi","year":"2011","journal-title":"J Orthop Surg Res"},{"key":"R17-20251008","doi-asserted-by":"crossref","first-page":"284","DOI":"10.4329\/wjr.v6.i6.284","article-title":"A handy review of carpal tunnel syndrome: From anatomy to diagnosis and treatment","volume":"6","author":"Ghasemi-Rad","year":"2014","journal-title":"World J Radiol"},{"key":"R18-20251008","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1016\/j.apmr.2014.06.022","article-title":"Carpal tunnel syndrome: Hand surgeons, hand therapists, and physical medicine and rehabilitation physicians agree on a multidisciplinary treatment guideline \u2013 Results from the European HANDGUIDE Study","volume":"95","author":"Huisstede","year":"2014","journal-title":"Arch Phys Med Rehabil"},{"key":"R19-20251008","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1471-2377-1-8","article-title":"Splinting or surgery for carpal tunnel syndrome? Design of a randomized controlled trial [ISRCTN18853827]","volume":"1","author":"Gerritsen","year":"2001","journal-title":"BMC Neurol"},{"key":"R20-20251008","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1600-0404.2008.01072.x","article-title":"Efficacy of a soft hand brace and a wrist splint for carpal tunnel syndrome: A randomized controlled study","volume":"119","author":"De Angelis","year":"2009","journal-title":"Acta Neurol Scand"},{"key":"R21-20251008","first-page":"CD010003","article-title":"Splinting for carpal tunnel syndrome","volume":"7","author":"Page","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"R22-20251008","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1177\/1753193413490848","article-title":"Cochrane corner: Local corticosteroid injection for carpal tunnel syndrome","volume":"38","author":"Stark","year":"2013","journal-title":"J Hand Surg Eur Vol"},{"key":"R23-20251008","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1097\/01.PRS.0000101055.76543.C7","article-title":"A prospective study to assess the outcome of steroid injections and wrist splinting for the treatment of carpal tunnel syndrome","volume":"113","author":"Graham","year":"2004","journal-title":"Plast Reconstr Surg"},{"key":"R24-20251008","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s10072-004-0229-0","article-title":"Long-term effectiveness of steroid injections and splinting in mild and moderate carpal tunnel syndrome","volume":"25","author":"Sevim","year":"2004","journal-title":"Neurol Sci"},{"key":"R25-20251008","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s00296-006-0163-y","article-title":"Comparison of splinting, splinting plus local steroid injection and open carpal tunnel release outcomes in idiopathic carpal tunnel syndrome","volume":"27","author":"Ucan","year":"2006","journal-title":"Rheumatol Int"},{"key":"R26-20251008","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1136\/jnnp.74.9.1342","article-title":"Splinting for carpal tunnel syndrome: Prognostic indicators of success","volume":"74","author":"Gerritsen","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"R27-20251008","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/AJP.0b013e3181847a19","article-title":"Effectiveness of steroid injection in treating patients with moderate and severe degree of carpal tunnel syndrome measured by clinical and electrodiagnostic assessment","volume":"25","author":"Lee","year":"2009","journal-title":"Clin J Pain"},{"key":"R28-20251008","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1471-2474-11-76","article-title":"Local steroid injection for moderately severe idiopathic carpal tunnel syndrome: Protocol of a randomized double-blind placebo-controlled trial (NCT 00806871)","volume":"11","author":"Flondell","year":"2010","journal-title":"BMC Musculoskelet Disord"}],"container-title":["Advanced Biomedical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01679891-201605000-00016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T19:27:00Z","timestamp":1786735620000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/2277-9175.175902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.4103\/2277-9175.175902","relation":{},"ISSN":["2277-9175"],"issn-type":[{"value":"2277-9175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"2015-05-07","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-17","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}