{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:40:32Z","timestamp":1786653632924,"version":"build-2736575974"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,1]]},"abstract":"\n Background:<\/jats:title>\n Preterm birth, defined as birth occurring before 37 weeks of gestation, is a common complication of pregnancy and may lead to death or long-term disability in newborns. Accurate diagnosis is, therefore, crucial for identifying those women undergoing preterm labor who are at greatest risk of preterm delivery. This may allow transport to a regional obstetrical center and permit time for corticosteroid therapy. Recent study recommends several markers such as CRP (C-reactive protein) and ALK-P (alkaline phosphatase) to predict preterm delivery.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n We select a total of 300 pregnant women that had symptoms of premature birth. All of them were under treatment with tocolytic and serum sample were taken to assess the level of CRP-ALKp. Cervix length and the time of response to tocolytic were measured. 110 pregnant of them had preterm labor. 110 patient that had a term labor selected as a control group.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Qualitative evaluation of efficacy CRP level on preterm delivery showed a significant relationship with 27 as a cut of point of CRP (\n P<\/jats:italic>\n < 0.00001 \u2013OR = 7.5). Investigate of effect of ALK-P level on preterm delivery refers to a significant relationship with 399 as a cut of point of ALKP (\n P<\/jats:italic>\n < 0.00001 \u2013OR = 5). Inquire of efficacy of CRP level and ALK-P level on preterm delivery demonstrate a significant relationship (\n P<\/jats:italic>\n < 0.0001 1OR = 9).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n Maternal concentrations of CRP and ALKP and cervix length can be used as appropriate biomarker for predicting preterm labor and response to tocolytic therapy in pregnant women.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/2277-9175.175903","type":"journal-article","created":{"date-parts":[[2016,2,8]],"date-time":"2016-02-08T01:49:15Z","timestamp":1454896155000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of CRP and ALK-P serum levels in prediction of preterm delivery"],"prefix":"10.4103","volume":"5","author":[{"given":"Zahra","family":"Shahshahan","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoda","family":"Iravani","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2016,2,8]]},"reference":[{"key":"R1-20251008","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(08)60074-4","article-title":"Epidemiology and causes of preterm birth","volume":"371","author":"Goldenberg","year":"2008","journal-title":"Lancet"},{"key":"R2-20251008","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1471-2393-11-19","article-title":"Protocol for a randomised controlled trial of treatment of asymptomatic candidiasis for the prevention of preterm birth [ACTRN12610000607077]","volume":"11","author":"Roberts","year":"2011","journal-title":"BMC Pregnancy Childbirth"},{"key":"R3-20251008","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0002-9378(96)70271-5","article-title":"Cervical fetal fibronectin in patients at increased risk for preterm delivery","volume":"175","author":"Bittar","year":"1996","journal-title":"Am J Obstet Gynecol"},{"key":"R4-20251008","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/14767050500246292","article-title":"Re-evaluating the role of the MFM specialist: Lead, follow, or get out of the way","volume":"18","author":"Eden","year":"2005","journal-title":"J Matern Fetal Neonatal Med"},{"key":"R5-20251008","first-page":"622","article-title":"Histologic chorioamnionitis and preterm delivery in different patient populations","volume":"75","author":"Mueller-Heubach","year":"1990","journal-title":"Obstet Gynecol"},{"key":"R6-20251008","first-page":"262","article-title":"Infection in the pathogenesis of preterm labor","volume":"12","author":"Romero","year":"1988","journal-title":"Semin Perinatol"},{"key":"R7-20251008","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1600-051X.2004.00630.x","article-title":"Periodontitis, a marker of risk in pregnancy for preterm birth","volume":"32","author":"D\u00f6rtbudak","year":"2005","journal-title":"J Clin Periodontol"},{"key":"R8-20251008","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1177\/002203450208100113","article-title":"Higher risk of preterm birth and low birth weight in women with periodontal disease","volume":"81","author":"L\u00f3pez","year":"2002","journal-title":"J Dent Res"},{"key":"R9-20251008","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1902\/annals.2001.6.1.164","article-title":"Maternal periodontitis and prematurity. 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