{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:40:54Z","timestamp":1786653654113,"version":"build-2736575974"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,1]]},"abstract":"\n Background:<\/jats:title>\n Acne vulgaris is the most common skin disease. Local and systemic antimicrobial drugs are used for its treatment. But increasing resistance of Propionibacterium acnes to antibiotics has been reported.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n In a double-blind clinical trial, 40 patients with mild to moderate acne vulgaris were recruited. one side of the face was treated with Clindamycin Gel 1% and the other side with Azithromycin Topical Gel 2% BID for 8 weeks and then they were assessed.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Average age was 21. 8 \u00b1 7 years. 82.5% of them were female. Average number of papules, pustules and comedones was similarly reduced in both groups and, no significant difference was observed between the two groups (\n P<\/jats:italic>\n > 0.05, repeated measurs ANOVA). The mean indexes of ASI and TLC also significantly decreased during treatment in both groups, no significant difference was observed between the two groups. (\n P<\/jats:italic>\n > 0.05, repeated measurs ANOVA). Also, impact of both drugs on papules and pustules was 2-3 times greater than the effect on comedones. Average satisfaction score was not significant between the two groups (\n P<\/jats:italic>\n = 0.6, repeated measurs ANOVA). finally, frequency distribution of complications was not significant between the two groups (\n P<\/jats:italic>\n > 0.05, Fisher Exact test).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Azithromycin gel has medical impact at least similar to Clindamycin Gel in treatment of mild to moderate acne vulgaris, and it may be consider as suitable drug for resistant acne to conventional topical therapy.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/2277-9175.180641","type":"journal-article","created":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T02:41:06Z","timestamp":1461033666000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Comparison effect of azithromycin gel 2% with clindamycin gel 1% in patients with acne"],"prefix":"10.4103","volume":"5","author":[{"given":"Fatemeh","family":"Mokhtari","sequence":"first","affiliation":[{"name":"Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gita","family":"Faghihi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akram","family":"Basiri","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadaf","family":"Farhadi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadali","family":"Nilforoushzadeh","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadi","family":"Behfar","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2016,4,19]]},"reference":[{"key":"R3-20251008","first-page":"644","article-title":"Tolerability and irritation potential of four topical acne regimens in healthy subjects","volume":"12","author":"Grove","year":"2013","journal-title":"J Drugs Dermatol"},{"key":"R6-20251008","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2165\/00128071-200405020-00002","article-title":"Topical antibacterial 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Treat"},{"key":"R18-20251008","first-page":"86","article-title":"Pulsed azithromycin treatment is as effective and safe as 2-week-longer daily doxycycline treatment of acne vulgaris: A randomized, double-blind, noninferiority study","volume":"9","author":"Maleszka","year":"2011","journal-title":"Skinmed"},{"key":"R19-20251008","first-page":"42","article-title":"Combination of low-dose isotretinoin and pulsed oral azithromycin for maximizing efficacy of acne treatment","volume":"22","author":"Hasibur","year":"2013","journal-title":"Mymensingh Med J"},{"key":"R20-20251008","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1080\/09546630410033808","article-title":"A topical azithromycin preparation for the treatment of acne vulgaris and rosacea","volume":"15","author":"McHugh","year":"2004","journal-title":"J Dermatolog Treat"},{"key":"R21-20251008","first-page":"67","article-title":"Comparison of topical azithromycin and clindamycin in the treatment of mild to moderate acne 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