{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:41:03Z","timestamp":1786653663402,"version":"build-2736575974"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Myeloperoxidase (MPO) is an enzyme, elevated in the atheroma and serum of a patient with atherosclerotic vessels. The aim of this study is to investigate whether the serum MPO level is related to the presence of plaque in patients without risk factors, such as, diabetes, hypertension, obesity, and hyperlipidemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>A serum sample was collected from patients who referred for angiography. The MPO level was measured in the serum samples of 40 patients without risk factors for atherosclerosis using the enzyme-linked immunosorbent assay (ELISA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The MPO level was 245.5 \u00b1 13.8 (ng\/ml) in patients with atherosclerosis and 213.9 \u00b1 8.9 (ng\/ml) in patients without atherosclerosis. There was a significant difference between the groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.002). The odds ratio was 0.67 (0.95 CI, 0.17 \u2013 2.5) for patients with and without coronary atherosclerosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although the MPO concentration is higher in patients suffering from atherosclerosis, it is not a predictor of coronary artery disease in patients without diabetes, hypertension, obesity, and hyperlipidemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/2277-9175.183663","type":"journal-article","created":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T02:48:59Z","timestamp":1465354139000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":12,"title":["Association between serum myeloperoxidase levels and coronary artery disease in patients without diabetes, hypertension, obesity, and hyperlipidemia"],"prefix":"10.4103","volume":"5","author":[{"given":"Zahra","family":"Hasanpour","sequence":"first","affiliation":[{"name":"Department of Physiology, Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaghayegh Haghjooy","family":"Javanmard","sequence":"additional","affiliation":[{"name":"Department of Physiology, Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Gharaaty","sequence":"additional","affiliation":[{"name":"Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoumeh","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2016,6,8]]},"reference":[{"key":"R1-20251008","doi-asserted-by":"crossref","first-page":"240","DOI":"10.4037\/ajcc1998.7.3.240","article-title":"Fifty percent of patients with coronary artery disease do not have any of the conventional risk factors","volume":"7","author":"Futterman","year":"1998","journal-title":"Am J Crit Care"},{"key":"R2-20251008","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1001\/jama.290.7.898","article-title":"Prevalence of conventional risk factors in patients with coronary heart disease","volume":"290","author":"Khot","year":"2003","journal-title":"JAMA"},{"key":"R3-20251008","doi-asserted-by":"crossref","first-page":"11961","DOI":"10.1073\/pnas.211190298","article-title":"Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis","volume":"98","author":"Gaut","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R4-20251008","doi-asserted-by":"crossref","DOI":"10.1155\/2008\/135625","article-title":"Myeloperoxidase: A new biomarker of inflammation in ischemic heart disease and acute coronary syndromes","author":"Loria","year":"2008","journal-title":"Mediators Inflamm 2008"},{"key":"R5-20251008","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0160-5402(85)90029-4","article-title":"Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium","volume":"14","author":"Mullane","year":"1985","journal-title":"J Pharmacol Methods"},{"key":"R6-20251008","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1164\/ajrccm.160.1.9807044","article-title":"Reactive nitrogen species and tyrosine nitration in the respiratory tract: Epiphenomena or a pathobiologic mechanism of disease?","volume":"160","author":"van der Vliet","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"R7-20251008","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1161\/01.ATV.0000163262.83456.6d","article-title":"Myeloperoxidase and cardiovascular disease","volume":"25","author":"Nicholls","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R8-20251008","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1172\/JCI5549","article-title":"Myeloperoxidase-generated reactive nitrogen species convert LDL into an atherogenic form in vitro","volume":"103","author":"Podrez","year":"1999","journal-title":"J Clin Invest"},{"key":"R9-20251008","doi-asserted-by":"crossref","first-page":"41279","DOI":"10.1074\/jbc.M106958200","article-title":"Hypochlorous acid oxygenates the cysteine switch domain of pro-matrilysin (MMP-7). 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