{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:40:29Z","timestamp":1786653629685,"version":"build-2736575974"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Carpal tunnel syndrome (CTS) considers the most common compression neuropathy, which nerve conduction studies (NCSs) used for its detection routinely and universally. This study was performed to determine the value of the median TLI and other NCS variables and to investigate their sensitivity and specificity in the diagnosis of CTS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>The study was carried out among 100 hands of healthy volunteers and 50 hands of patients who had a positive history of paresthesia and numbness in upper extremities. Information including age, gender, and result of sensory and motor nerve conduction velocity (MNCV), peak latency difference of median and ulnar nerves of fourth digit (M4-U4 peak latency difference), and TLI were recorded for analysis. Sensitivity and specificity of electro diagnostic parameters in the diagnosis of CTS was investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Normal range of the median nerve TLI was 0.43 \u00b1 0.077. There was no significant difference between two groups for MNCV means (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0. 45). Distal sensory latency and distal motor latency (DML) of median nerve and fourth digit median-ulnar peak latency differences (PM4-PU4) for CTS group was significantly higher (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001) and mean for sensory nerve conduction velocity was significantly higher in control group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). The most sensitive electrophysiological finding in CTS patients was median TLI (82%), but the most specific one was DML (98%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although in early stages of CTS, we usually expect only abnormalities in the sensory studies, but TLI may better demonstrate the effect on median nerve motor fiber even in mild cases of CTS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/2277-9175.183671","type":"journal-article","created":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T03:29:21Z","timestamp":1465356561000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":9,"title":["The role of median nerve terminal latency index in the diagnosis of carpal tunnel syndrome in comparison with other electrodiagnostic parameters"],"prefix":"10.4103","volume":"5","author":[{"given":"Babak","family":"Vahdatpour","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeid","family":"Khosrawi","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Chatraei","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2016,6,8]]},"reference":[{"key":"R1-20251008","first-page":"1078","article-title":"Sensitivity and specificity of terminal latency index and residual latency in the diagnosis of carpal tunnel syndrome","volume":"15","author":"Uzar","year":"2011","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"R3-20251008","first-page":"12","article-title":"Sensitivities of conventional and new electrophysiological techniques in carpal tunnel syndrome and their relationship to body mass index","volume":"4","author":"Ayg\u00fcl","year":"2009","journal-title":"J Brachial Plex Peripher Nerve Inj"},{"key":"R4-20251008","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1177\/230949900301100215","article-title":"The relationship between nerve conduction study and clinical grading of carpal tunnel syndrome","volume":"11","author":"Ogura","year":"2003","journal-title":"J Orthop Surg (Hong Kong)"},{"key":"R5-20251008","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1054\/JHSB.2001.0669","article-title":"Nerve conduction studies for carpal tunnel syndrome: Essential prelude to surgery or unnecessary luxury?","volume":"27","author":"Smith","year":"2002","journal-title":"J Hand Surg Br"},{"key":"R6-20251008","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3109\/02844319309079790","article-title":"Neurophysiological diagnosis of the carpal tunnel syndrome: Evaluation of neurographic techniques","volume":"27","author":"Ros\u00e9n","year":"1993","journal-title":"Scand J Plast Reconstr Surg Hand Surg"},{"key":"R7-20251008","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S0924-980X(98)00018-6","article-title":"Median mixed and sensory nerve conduction studies in carpal tunnel syndrome","volume":"109","author":"Scelsa","year":"1998","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"R8-20251008","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1002\/mus.880161220","article-title":"Literature review of the usefulness of nerve conduction studies and electromyography for the evaluation of patients with carpal tunnel syndrome. AAEM Quality Assurance Committee","volume":"16","author":"Jablecki","year":"1993","journal-title":"Muscle Nerve"},{"key":"R9-20251008","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0022-510X(94)90076-0","article-title":"Carpal tunnel syndrome in 100 patients: Sensitivity, specificity of multi-neurophysiological procedures and estimation of axonal loss of motor, sensory and sympathetic median nerve fibers","volume":"127","author":"Kuntzer","year":"1994","journal-title":"J Neurol Sci"},{"key":"R10-20251008","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1002\/(SICI)1097-4598(199709)20:9<1178::AID-MUS14>3.0.CO;2-P","article-title":"Terminal latency index in the carpal tunnel syndrome","volume":"20","author":"Simovic","year":"1997","journal-title":"Muscle Nerve"},{"key":"R11-20251008","first-page":"934","article-title":"Determination of the median nerve residual latency values in the diagnosis of carpal tunnel syndrome in comparison with other electrodiagnostic parameters","volume":"18","author":"Khosrawi","year":"2013","journal-title":"J Res Med Sci"},{"key":"R12-20251008","first-page":"206","article-title":"Sensory latencies to the ring finger: Normal values and relation to carpal tunnel syndrome","volume":"62","author":"Johnson","year":"1981","journal-title":"Arch Phys Med Rehabil"},{"key":"R13-20251008","first-page":"105","article-title":"Terminal latency index and residual latency in Carpal Tunnel Syndrome","volume":"15","author":"Karata","year":"2000","journal-title":"Romatizma"},{"key":"R14-20251008","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/(SICI)1097-4598(199905)22:5<573::AID-MUS4>3.0.CO;2-A","article-title":"The median nerve terminal latency index in carpal tunnel syndrome: A clinical case selection study","volume":"22","author":"Simovic","year":"1999","journal-title":"Muscle Nerve"},{"key":"R15-20251008","first-page":"3","article-title":"Determination of terminal latency index in carpal tunnel syndrome","volume":"28","author":"Shakouri","year":"2006","journal-title":"Med J Tabriz Univ Med Sci"}],"container-title":["Advanced Biomedical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01679891-201605000-00110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:40:11Z","timestamp":1786650011000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01679891-201605000-00110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.4103\/2277-9175.183671","relation":{},"ISSN":["2277-9175"],"issn-type":[{"value":"2277-9175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"2014-05-18","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-16","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}