{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:40:31Z","timestamp":1786653631342,"version":"build-2736575974"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Hypercoagulable state is a common serious problem in patients with end-stage renal disease (ESRD). ESRD patients are in a condition of chronic inflammation. An increased level of E-selectin, \u201ca key adhesion molecule that regulates leukocyte bindings to endothelium at damaged sites,\u201d accompanies the higher risk of inflammation in ESRD patients. We aimed to investigate the possible correlation among E-selectin as an adhesion molecule, coagulation factors, and inflammatory factors in children with ESRD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Thirty-five child patients with ESRD who had been on regular dialysis treatment were registered in our study. Nighteen sex- and age-matched healthy volunteers were used as the control group. Laboratory tests were requested for the evaluation of hematological and biochemical parameters, and parathyroid hormone (PTH), and for coagulation state; fibrinogen, protein C, and protein S were measured. The enzyme-linked immunosorbent assay (ELISA) (Biomerica, CA, and IDS, UK). for serum E-selectin assay was provided by R and D Systems (Abingdon, UK).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Hemoglubolin (Hb), blood urea nitrogen (BUN), creatinine, calcium, PTH, triglyceride (TG) concentrations in serum as well as E-selectin showed significant difference between the two study groups, as indeed was expected. Serum E-selectin was significantly higher (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value = 0.033) in dialysis patients than in healthy subjects. E-selectin was positively correlated only with phosphorus in ESRD children (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.398,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.018). No association was found for other parameters.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Although in our study circulating E-selectin concentration \u201cas an inflammatory maker\u201d is independently positively associated with limited blood markers, for better evaluation, well-designed cohort studies should be examined in ESRD children.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/2277-9175.186992","type":"journal-article","created":{"date-parts":[[2016,7,26]],"date-time":"2016-07-26T05:47:48Z","timestamp":1469512068000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Association of E-selectin with hematological, hormonal levels and plasma proteins in children with end stage renal disease"],"prefix":"10.4103","volume":"5","author":[{"given":"Rokhsareh","family":"Meamar","sequence":"first","affiliation":[{"name":"Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"},{"name":"Department of Medical Sciences, Najafabad Branch, Islamic Azad University, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Shafiei","sequence":"additional","affiliation":[{"name":"Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amin","family":"Abedini","sequence":"additional","affiliation":[{"name":"Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza Aghaye","family":"Ghazvini","sequence":"additional","affiliation":[{"name":"Isfahan Center of Health Research, Isfahan University of Medical Sciences, Isfahan, Iran"},{"name":"National Institute of Health Research, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peyman","family":"Roomizadeh","sequence":"additional","affiliation":[{"name":"Isfahan Kidney Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shahram","family":"Taheri","sequence":"additional","affiliation":[{"name":"National Institute of Health Research, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaleh","family":"Gheissari","sequence":"additional","affiliation":[{"name":"National Institute of Health Research, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2016,7,29]]},"reference":[{"issue":"Suppl 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