{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:41:14Z","timestamp":1786653674456,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Pemphigus vulgaris is a chronic inflammatory disease of skin, the etiology of which is not completely known. Despite the latter, anti-desmoglein antibodies play a proven role in the pathogenesis. Recent studies showed an etiologic effect for prolactin in the pemphigus vulgaris. This study aimed to quantify the correlation between serum prolactin levels and anti-desmoglein antibodies in patients with pemphigus vulgaris.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>Prolactin and antibodies against desmoglein 1 and 3 measured with ELISA in 14 new subjects of pemphigus vulgaris.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      There was no statistically significant relation between both serum prolactin and anti-desmoglein1 levels (r = 0.02,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.47) and serum prolactin and anti-desmoglein 3 levels (r= -0.09,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.38).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study indicates that no correlation was found between serum prolactin levels and anti-desmoglein 1 levels and serum prolactin and anti-desmoglein 3 levels. However, other studies should be initiated regarding exact molecular and cellular effects of prolactin in the pathogenesis of pemphigus vulgaris.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/2277-9175.191002","type":"journal-article","created":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T01:18:44Z","timestamp":1474420724000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Do serum prolactin levels correlate with antibodies against desmoglein in pemphigus vulgaris?"],"prefix":"10.4103","volume":"5","author":[{"given":"Fariba","family":"Iraji","sequence":"first","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabet","family":"Tajmirriahi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman","family":"Momeni","sequence":"additional","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kioumars","family":"Jamshidi","sequence":"additional","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fazlollah","family":"Hashemzehi","sequence":"additional","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Hossein","family":"Siadat","sequence":"additional","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza Asemi","family":"Esfahani","sequence":"additional","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Center, Department of Dermatology, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2016,12,27]]},"reference":[{"key":"R2-20251008","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1046\/j.1365-2230.2000.00624.x","article-title":"Diagnosis of pemphigus by ELISA: A critical evaluation of two ELISAs for the detection of antibodies to the major pemphigus antigens, desmoglein 1 and 3","volume":"25","author":"Harman","year":"2000","journal-title":"Clin Exp Dermatol"},{"key":"R3-20251008","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1001\/archdermatol.2009.324","article-title":"Prevalence of autoantibodies to bullous pemphigoid antigens within the normal population","volume":"146","author":"Fine","year":"2010","journal-title":"Arch Dermatol"},{"key":"R4-20251008","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1111\/j.1582-4934.2007.00033.x","article-title":"Immunopathology and molecular diagnosis of autoimmune bullous diseases","volume":"11","author":"Mihai","year":"2007","journal-title":"J Cell Mol Med"},{"key":"R5-20251008","first-page":"215","article-title":"Pemphigus vulgaris: Recent advances in our understanding of its pathogenesis","volume":"56","author":"Femiano","year":"2007","journal-title":"Minerva Stomatol"},{"issue":"1 Suppl","key":"R6-20251008","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/j.jaad.2004.01.011","article-title":"Pemphigus vulgaris-a model for cutaneous autoimmunity","volume":"51","author":"Anhalt","year":"2004","journal-title":"J Am Acad Dermatol"},{"key":"R7-20251008","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.0022-202X.2004.22438.x","article-title":"Immunopathological mechanisms of acantholysis in pemphigus vulgaris: An explanation by ultrastructural observations","volume":"122","author":"Liu","year":"2004","journal-title":"J Invest Dermatol"},{"key":"R8-20251008","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1046\/j.1523-1747.1998.00085.x","article-title":"Lack of mucosal involvement in pemphigus foliaceus may be due to low expression of desmoglein 1","volume":"110","author":"Shirakata","year":"1998","journal-title":"J Invest Dermatol"},{"key":"R9-20251008","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.autrev.2006.10.005","article-title":"Hyperprolactinemia and autoimmune diseases","volume":"6","author":"Orbach","year":"2007","journal-title":"Autoimmun Rev"},{"key":"R10-20251008","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/S1568-9972(02)00081-2","article-title":"Prolactin and autoimmunity","volume":"1","author":"Vera-Lastra","year":"2002","journal-title":"Autoimmun Rev"},{"key":"R11-20251008","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s12016-011-8256-0","article-title":"Prolactin and Autoimmunity","volume":"42","author":"Orbach","year":"2012","journal-title":"Clin Rev Allergy Immunol"},{"key":"R12-20251008","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1191\/096120398678920316","article-title":"Anti endothelial cell antibodies in the sera of hyper- prolactinemic women","volume":"7","author":"Krause","year":"1998","journal-title":"Lupus"},{"key":"R13-20251008","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1046\/j.1365-4362.2002.01393_1.x","article-title":"An unusual association of pemphigus vulgaris with hyperprolactinemia","volume":"41","author":"Khandpur","year":"2002","journal-title":"Int J Dermatol"},{"key":"R14-20251008","first-page":"52","article-title":"Serum Prolactin Levels in Beh\u00e7et's Disease. Is There a Relationship between Behcet's Disease and Prolactin as in Other Autoimmune Diseases?","volume":"21","author":"Avci","year":"2013","journal-title":"Acta Dermatovenerol Croat"},{"key":"R15-20251008","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4103\/0378-6323.25780","article-title":"Study of desmoglein 1 and 3 antibody levels in relation to severity in Indian patients with pemphigus","volume":"72","author":"Kumar","year":"2006","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"R16-20251008","first-page":"46","article-title":"Correlation of pemphigus vulgaris antibody titers by indirect immunofluorescence with activity of disease based on pemphigus area and activity score (PAAS)","author":"Mortazavi","year":"2008","journal-title":"Acta Med Iranica"},{"key":"R17-20251008","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/rheumatology\/kei115","article-title":"Serum free prolactin concentrations in patients with systemic lupus erythematosus are associated with lupus activity","volume":"45","author":"Leanos-Miranda","year":"2006","journal-title":"Rheumatology"},{"key":"R18-20251008","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1007\/s00296-006-0129-0","article-title":"Correlation between serum prolactin levels and lupus activity","volume":"26","author":"Rezaieyazdi","year":"2006","journal-title":"Rheumatol Int"},{"key":"R19-20251008","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1177\/0961203310373781","article-title":"Prolactin's role in the pathogenesis of the antiphospholipid syndrome","volume":"19","author":"Praprotnik","year":"2010","journal-title":"Lupus"},{"key":"R20-20251008","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.jaad.2009.09.051","article-title":"Elevation of serum prolactin levels in patients with pemphigus vulgaris: A novel finding with practical implications","volume":"62","author":"Fallahzadeh","year":"2010","journal-title":"J Am Acad Dermatol"},{"key":"R21-20251008","first-page":"79","article-title":"Does prolactin indicate severity of psoriasis?","volume":"12","author":"Azizzadeh","year":"2009","journal-title":"Iran J Dermatol"}],"container-title":["Advanced Biomedical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01679891-201605000-00206","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:40:42Z","timestamp":1786650042000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01679891-201605000-00206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016]]}},"URL":"https:\/\/doi.org\/10.4103\/2277-9175.191002","relation":{},"ISSN":["2277-9175"],"issn-type":[{"value":"2277-9175","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"2013-08-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-10-06","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}