{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:26:53Z","timestamp":1787776013549,"version":"build-2784847793"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Valproic acid (VPA) is a widely used broad-spectrum antiepileptic drug for therapy of generalized and focal epilepsies. Cross-sectional studies have suggested that valproate treatment may be associated with hyperinsulinemia. We decided to investigate hyperinsulinemia as a health-threatening side effect of VPA in Iranian epileptic patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Body mass index (BMI), lipid profile, fasting serum insulin, fasting blood glucose (FBS), and homeostatic model assessment-insulin resistance (HOMA-IR) were measured in 30 VPA-treated epileptic patients and 30 controls (CBZ-treated). The Chi-square test,\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -test, and Pearson correlation test were used.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      BMI was higher in VPA group than in control group (25.7 \u00b1 3.5 &gt; 21.7 \u00b1 4.1) (0.000 &lt; 0.05). Prevalence of obesity was 16.6% in VPA group that was almost the same and even lower than general Iranian population. Serum triglyceride (TG) (150 \u00b1 77.2) was higher than CBZ group (114 \u00b1 35.2) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.023 &lt; 0.05). However, serum high-density lipoprotein level was lower in VPA group than controls (45.2 \u00b1 11.7 &lt; 54.4 \u00b1 13.9) (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.008 &lt; 0.05). Serum insulin, FBS, HOMA-IR, cholesterol, and low-density lipoprotein did not demonstrate statistically significant differences between the two groups (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Despite the majority of previous studies that are against VPA and according to our study, VPA could be prescribed safely and it may not cause IR and its complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/2277-9175.201689","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T03:53:26Z","timestamp":1488858806000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":10,"title":["The Investigation of Insulin Resistance in Two Groups of Epileptic Patients Treated with Sodium Valproate and Carbamazepine"],"prefix":"10.4103","volume":"6","author":[{"given":"Mohammad Reza","family":"Najafi","sequence":"first","affiliation":[{"name":"From the Department of Neurology, Isfahan Neurosciences Research Center, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bahareh","family":"Bazooyar","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Babol University of Medical Sciences, Babol, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Zare","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Isfahan Neurosciences Research Center, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Aghaghazvini","sequence":"additional","affiliation":[{"name":"Health Research Center, Tehran University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behnaz","family":"Ansari","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Isfahan Neurosciences Research Center, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Rajaei","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Isfahan Neurosciences Research Center, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoumeh","family":"Dashti","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Isfahan Neurosciences Research Center, Alzahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,3,7]]},"reference":[{"key":"R1-20250806","doi-asserted-by":"crossref","first-page":"332","DOI":"10.2165\/00003495-199447020-00008","article-title":"Valproic acid. 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