{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:26:31Z","timestamp":1787775991409,"version":"build-2784847793"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                      species can become opportunistic pathogens causing local or systemic invasive infections. Gastroesophageal candidiasis may depend on the\n                      <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                      colonization and local damage of the mucosal barrier. Risk factors are gastric acid suppression, diabetes mellitus, chronic debilitating states such as carcinomas, and the use of systemic antibiotics and corticosteroids. The aim of this study is collection and molecular identification of\n                      <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                      species from gastroesophageal lesions among pediatrics in Isfahan, and determination of minimum inhibitory concentration (MIC) ranges for clinical isolates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      A total of 200 patients underwent endoscopy (130 specimens from gastritis and 70 samples from esophagitis) were included in this study between April 2015 and November 2015. All specimens were subcultured on sabouraud dextrose agar, and genomic DNA of all strains was extracted using boiling method. Polymerase chain reaction and DNA sequencing of the ITS1-5.8SrDNA-ITS2 region were used for the identification of all\n                      <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                      strains. MIC ranges were determined for itraconazole (ITC), amphotericin B (AmB), and fluconazole (FLU) by E-test.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Twenty of 200 suspected patients (10%) were positive by direct microscopy and culture.\n                      <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                      was the most common species (60%) followed by\n                      <jats:italic toggle=\"yes\">Candida glabrata<\/jats:italic>\n                      (30%),\n                      <jats:italic toggle=\"yes\">Candida parapsilosis<\/jats:italic>\n                      (5%), and\n                      <jats:italic toggle=\"yes\">Candida kefyr<\/jats:italic>\n                      (5%). MIC ranges were determined for FLU (0.125\u20138 \u03bcg\/mL), ITC (0.008\u20130.75 \u03bcg\/mL), and AmB (0.008\u20130.75 \u03bcg\/mL), respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Every colonization of\n                      <jats:italic toggle=\"yes\">Candida<\/jats:italic>\n                      species should be considered as a potentially factor of mucocutaneous candidiasis and should be treated with antifungal drugs.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/2277-9175.213662","type":"journal-article","created":{"date-parts":[[2017,8,28]],"date-time":"2017-08-28T02:56:23Z","timestamp":1503888983000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Isolation of Candida Species from Gastroesophageal Lesions among Pediatrics in Isfahan, Iran: Identification and Antifungal Susceptibility Testing of Clinical Isolates by E-test"],"prefix":"10.4103","volume":"6","author":[{"given":"Fatemeh","family":"Salehi","sequence":"first","affiliation":[{"name":"From the Department of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehran","family":"Esmaeili","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasoul","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"From the Department of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2017,8,28]]},"reference":[{"key":"R1-20250806","doi-asserted-by":"crossref","first-page":"95","DOI":"10.2147\/TCRM.S40160","article-title":"Epidemiology and risk factors for invasive candidiasis","volume":"10","author":"Yapar","year":"2014","journal-title":"Ther Clin Risk Manag"},{"key":"R2-20250806","doi-asserted-by":"crossref","first-page":"e58217","DOI":"10.1371\/journal.pone.0058217","article-title":"Factors associated with esophageal candidiasis and its endoscopic severity in the era of antiretroviral therapy","volume":"8","author":"Nishimura","year":"2013","journal-title":"PLoS One"},{"key":"R3-20250806","doi-asserted-by":"crossref","first-page":"e1003550","DOI":"10.1371\/journal.ppat.1003550","article-title":"Emerging and emerged pathogenic Candida species: Beyond the Candida albicans paradigm","volume":"9","author":"Papon","year":"2013","journal-title":"PLoS Pathog"},{"key":"R4-20250806","doi-asserted-by":"crossref","first-page":"363764","DOI":"10.1155\/2012\/363764","article-title":"Hosting infection: Experimental models to assay Candida virulence","volume":"2012","author":"Maccallum","year":"2012","journal-title":"Int J Microbiol"},{"key":"R5-20250806","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1590\/S1516-89132012000200020","article-title":"Rapid yeast DNA extraction by boiling and freeze-thawing without using chemical reagents and DNA purification","volume":"55","author":"Silva","year":"2012","journal-title":"Braz Arch Biol Technol"},{"key":"R6-20250806","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.bjm.2015.02.001","article-title":"Rapid detection of Candida species in bronchoalveolar lavage fluid from patients with pulmonary symptoms","volume":"47","author":"Zarrinfar","year":"2016","journal-title":"Braz J Microbiol"},{"key":"R7-20250806","first-page":"43","article-title":"Candidiasis in pediatrics; identification and In vitro antifungal susceptibility of the clinical isolates","volume":"6","author":"Mohammadi","year":"2016","journal-title":"Iran J Ped Hematol Oncol"},{"key":"R8-20250806","doi-asserted-by":"crossref","first-page":"523","DOI":"10.14740\/jmc2337w","article-title":"Esophageal candidiasis in a patient with uncontrolled diabetes mellitus and recurrent abdominal pain, symptomatic or incidental? 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