{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:19:18Z","timestamp":1787840358622,"version":"build-2784847793"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Radicular pain is one of the most common forms of chronic pain in the world, which has challenges about effective medical therapy. The aim of this study was to evaluate the effect of pregabalin (PGB) and metformin (Met) on subacute and chronic radiculopathy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This double-blind prospective clinical trial was performed on 71 patients with subacute and chronic cervical and lumbosacral radiculopathy. Group A was treated with PGB 75 mg daily while Group B was treated with PGB 75 mg daily and Met 500 mg daily for 3 months. Finally, the pain score in both groups was evaluated based on visual analog scale (VAS) and numerical scale pain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The results showed a significant reduction in VAS and pain severity in both groups but this reduction in the terms of VAS (47.79% vs. 46.48%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.125) and pain severity (47.1% vs. 39.2%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.264) was more in treated patients with PGB and Met as compared to PGB group while total pain experience (53.5% vs. 49.1%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.464) and interference with daily function (57.1% vs. 50.61%,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.726) were more in patients treated with PGB alone.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Our results showed that PGB and PGB + Met reduced pain intensity and interference with daily function while we did not observe significant differences between two groups. PGB alone would have the potentiality to become a simple and economic means to decrease radicular pain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/2277-9175.225599","type":"journal-article","created":{"date-parts":[[2018,2,16]],"date-time":"2018-02-16T04:36:02Z","timestamp":1518755762000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["The Effect of Pregabalin and Metformin on Subacute and Chronic Radiculopathy"],"prefix":"10.4103","volume":"7","author":[{"given":"Behnaz","family":"Ansari","sequence":"first","affiliation":[{"name":"From the Department of Neurology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Ghasemi","sequence":"additional","affiliation":[{"name":"From the Department of Neurology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, 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