{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T05:10:50Z","timestamp":1793077850240,"version":"4.5.0"},"reference-count":0,"publisher":"Scientific Scholar","issue":"02","license":[{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"vor","delay-in-days":1361,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["South Asian J Cancer"],"published-print":{"date-parts":[[2017,4]]},"abstract":"Abstract<\/jats:title>\n Background: Concurrent chemoradiation\n with 3 weekly cisplatin (100 mg\/m2) is the\n standard of care for locally advanced head and\n neck cancer. However, this regimen has been shown\n to be associated with lesser compliance and higher\n toxicities. Hence, there is a need to explore\n alternative concurrent cisplatin regimens.\n Objectives: The objective of this study was to\n compare the efficacy and toxicities of 3 weekly\n cisplatin (100 mg\/m2) with weekly cisplatin (40\n mg\/m2) concurrently with radiation in patients\n with locally advanced head and neck cancer.\n Patients and Methods: This phase IIb trial\n randomized 56 patients with Stage III and IV\n squamous cell carcinoma of oropharynx,\n hypopharynx, and larynx to Arm A or Arm B. Arm A\n received cisplatin 100 mg\/m2 3 weekly and Arm B\n received cisplatin 40 mg\/m2 weekly concurrently\n with radiation. The primary end point was\n disease-free survival (DFS) and secondary end\n points were overall survival (OS) and acute\n toxicity. DFS and OS were estimated using\n Kaplan\u2013Meier method, and log-rank test was used to\n assess the difference in these distributions with\n respect to treatment. Results: The 2-year DFS in\n Arm A and Arm B was 64.5% and 52.8%, respectively\n (P = 0.67). The OS at 2 years was 71% and 61.1% in\n Arm A and Arm B, respectively (P = 0.61). There\n were no significant differences in acute\n hematological, renal, or mucosal toxicities\n between the two arms. Conclusion: This study\n showed a nonsignificant improvement in DFS and OS\n in the 3 weekly cisplatin arm over the weekly arm\n with comparable toxicities. The trial is\n registered with Clinical Trial Registry of India\n (CTRI registration number: CTRI\/2013\/05\/003703,\n URL-http:\/\/ctri.nic.in).<\/jats:p>","DOI":"10.4103\/2278-330x.208840","type":"journal-article","created":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T12:47:03Z","timestamp":1610369223000},"page":"064-068","source":"Crossref","is-referenced-by-count":6,"title":["Phase IIb trial comparing two concurrent\n cisplatin schedules in locally advanced head and\n neck cancer"],"prefix":"10.25259","volume":"06","author":[{"given":"Lekha Madhavan","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Regional Cancer Centre, Trivandrum, Kerala"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Rejnish","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Regional Cancer Centre, Trivandrum, Kerala"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kainickal Cessal","family":"Thomachan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Regional Cancer Centre, Trivandrum, Kerala"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malu","family":"Rafi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Regional Cancer Centre, Trivandrum, Kerala"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Preethi Sara","family":"George","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology and Biostatistics, Regional Cancer Centre, Trivandrum, Kerala"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.M. Jagathnath","family":"Krishna","sequence":"additional","affiliation":[{"name":"Department of Cancer Epidemiology and Biostatistics, Regional Cancer Centre, Trivandrum, Kerala"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunnambath","family":"Ramadas","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Regional Cancer Centre, Trivandrum, Kerala"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"10894","published-online":{"date-parts":[[2020,12,22]]},"container-title":["South Asian Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.4103\/2278-330X.208840.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:11:34Z","timestamp":1781176294000},"score":1,"resource":{"primary":{"URL":"https:\/\/journal.sajc.org\/phase-iib-trial-comparing-two-concurrent-cisplatin-schedules-in-locally-advanced-head-and-neck-cancer\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":0,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2020,12,22]]},"published-print":{"date-parts":[[2017,4]]}},"URL":"https:\/\/doi.org\/10.4103\/2278-330x.208840","relation":{},"ISSN":["2278-330X","2278-4306"],"issn-type":[{"value":"2278-330X","type":"print"},{"value":"2278-4306","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4]]}}}