{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:37:04Z","timestamp":1790638624479,"version":"4.1.0"},"reference-count":69,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Circ"],"published-print":{"date-parts":[[2016]]},"DOI":"10.4103\/2394-8108.192521","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T01:44:52Z","timestamp":1476755092000},"page":"108","source":"Crossref","is-referenced-by-count":20,"title":["Tracking mesenchymal stem cells using magnetic resonance imaging"],"prefix":"10.4103","volume":"2","author":[{"given":"Teng","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JensT","family":"Rosenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuegang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Grant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/2394-8108.192521-1","first-page":"159","volume-title":"Transplantation of bone marrow-derived stem cells: A promising therapy for stroke","author":"Tang","year":"2007","journal-title":"Cell Transplant"},{"key":"key-10.4103\/2394-8108.192521-2","first-page":"13","volume-title":"Neuroprotective effects of human mesenchymal stem cells on dopaminergic neurons through anti-inflammatory action","author":"Kim","year":"2009","journal-title":"Glia"},{"key":"key-10.4103\/2394-8108.192521-3","first-page":"47","volume-title":"Therapeutic benefits of angiogenetic gene-modified human mesenchymal stem cells after cerebral ischemia","author":"Toyama","year":"2009","journal-title":"Exp Neurol"},{"key":"key-10.4103\/2394-8108.192521-4","first-page":"14638","volume-title":"Stem\/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory\/immune responses","author":"Ohtaki","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key-10.4103\/2394-8108.192521-5","first-page":"329","volume-title":"Therapeutic benefits by human mesenchymal stem cells (hMSCs) and Ang-1 gene-modified hMSCs after cerebral ischemia","author":"Onda","year":"2008","journal-title":"J Cereb Blood Flow Metab"},{"key":"key-10.4103\/2394-8108.192521-6","first-page":"1495","volume-title":"Intravenous administration of glial cell line-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in the adult rat","author":"Horita","year":"2006","journal-title":"J Neurosci Res"},{"key":"key-10.4103\/2394-8108.192521-7","first-page":"301","volume-title":"Human stem cells for CNS repair","author":"Zietlow","year":"2008","journal-title":"Cell Tissue Res"},{"key":"key-10.4103\/2394-8108.192521-8","first-page":"395","volume-title":"Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis","author":"Vercelli","year":"2008","journal-title":"Neurobiol Dis"},{"key":"key-10.4103\/2394-8108.192521-9","first-page":"2518","volume-title":"Wild-type bone marrow cells ameliorate the phenotype of SOD1-G93A ALS mice and contribute to CNS, heart and skeletal muscle tissues","author":"Corti","year":"2004","journal-title":"Brain"},{"key":"key-10.4103\/2394-8108.192521-10","first-page":"523","volume-title":"Autologous mesenchymal stem cells: Clinical applications in amyotrophic lateral sclerosis","author":"Mazzini","year":"2006","journal-title":"Neurol Res"},{"key":"key-10.4103\/2394-8108.192521-11","first-page":"341","volume-title":"Adult mesenchymal stem cells for tissue engineering versus regenerative medicine","author":"Caplan","year":"2007","journal-title":"J Cell Physiol"},{"key":"key-10.4103\/2394-8108.192521-12","first-page":"1294","volume-title":"Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue","author":"Kern","year":"2006","journal-title":"Stem Cells"},{"key":"key-10.4103\/2394-8108.192521-13","first-page":"9142","volume-title":"Human bone marrow derived mesenchymal stem cells do not undergo transformation after long-term in vitro culture and do not exhibit telomere maintenance mechanisms","author":"Bernardo","year":"2007","journal-title":"Cancer Res"},{"key":"key-10.4103\/2394-8108.192521-14","first-page":"143","volume-title":"Multilineage potential of adult human mesenchymal stem cells","author":"Pittenger","year":"1999","journal-title":"Science"},{"key":"key-10.4103\/2394-8108.192521-15","first-page":"393","volume-title":"The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells","author":"Friedenstein","year":"1970","journal-title":"Cell Tissue Kinet"},{"key":"key-10.4103\/2394-8108.192521-16","first-page":"203","volume-title":"Mesenchymal stem cells transplantation could be beneficial for treatment of experimental ischemic stroke in rats","author":"Pavlichenko","year":"2008","journal-title":"Brain Res"},{"key":"key-10.4103\/2394-8108.192521-17","first-page":"318","volume-title":"Why are MSCs therapeutic.New data: New insight?","author":"Caplan","year":"2009","journal-title":"J Pathol"},{"key":"key-10.4103\/2394-8108.192521-18","first-page":"229","volume-title":"Remyelination of the spinal cord following intravenous delivery of bone marrow cells","author":"Akiyama","year":"2002","journal-title":"Glia"},{"key":"key-10.4103\/2394-8108.192521-19","first-page":"30","volume-title":"Optimization of a therapeutic protocol for intravenous injection of human mesenchymal stem cells after cerebral ischemia in adult rats","author":"Omori","year":"2008","journal-title":"Brain Res"},{"key":"key-10.4103\/2394-8108.192521-20","first-page":"2734","volume-title":"Neuroprotection by PlGF gene-modified human mesenchymal stem cells after cerebral ischaemia","author":"Liu","year":"2006","journal-title":"Brain"},{"key":"key-10.4103\/2394-8108.192521-21","first-page":"161","volume-title":"IV infusion of brain-derived neurotrophic factor gene-modified human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat","author":"Nomura","year":"2005","journal-title":"Neuroscience"},{"key":"key-10.4103\/2394-8108.192521-22","first-page":"56","volume-title":"Intravenous infusion of immortalized human mesenchymal stem cells protects against injury in a cerebral ischemia model in adult rat","author":"Honma","year":"2006","journal-title":"Exp Neurol"},{"key":"key-10.4103\/2394-8108.192521-23","first-page":"1","volume-title":"A therapeutic window for intravenous administration of autologous bone marrow after cerebral ischemia in adult rats","author":"Iihoshi","year":"2004","journal-title":"Brain Res"},{"key":"key-10.4103\/2394-8108.192521-24","first-page":"514","volume-title":"Human marrow stromal cell therapy for stroke in rat: Neurotrophins and functional recovery","author":"Li","year":"2002","journal-title":"Neurology"},{"key":"key-10.4103\/2394-8108.192521-25","first-page":"18","volume-title":"Mesenchymal and neural stem cells labeled with HEDP-coated SPIO nanoparticles: In vitro characterization and migration potential in rat brain","author":"Delcroix","year":"2009","journal-title":"Brain Res"},{"key":"key-10.4103\/2394-8108.192521-26","first-page":"49","volume-title":"Therapeutic benefit of intracerebral transplantation of bone marrow stromal cells after cerebral ischemia in rats","author":"Chen","year":"2001","journal-title":"J Neurol Sci"},{"key":"key-10.4103\/2394-8108.192521-27","first-page":"717","volume-title":"Magnetic nanoparticle labeling of mesenchymal stem cells without transfection agent: Cellular behavior and capability of detection with clinical 1.5 T magnetic resonance at the single cell level","author":"Hsiao","year":"2007","journal-title":"Magn Reson Med"},{"key":"key-10.4103\/2394-8108.192521-28","first-page":"101","volume-title":"In vivo MR imaging of tissue-engineered human mesenchymal stem cells transplanted to mouse: A preliminary study","author":"Ko","year":"2007","journal-title":"Ann Biomed Eng"},{"key":"key-10.4103\/2394-8108.192521-29","first-page":"105","volume-title":"Imaging of stem cells using MRI","author":"Kraitchman","year":"2008","journal-title":"Basic Res Cardiol"},{"key":"key-10.4103\/2394-8108.192521-30","first-page":"1141","volume-title":"Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells","author":"Bulte","year":"2001","journal-title":"Nat Biotechnol"},{"key":"key-10.4103\/2394-8108.192521-31","first-page":"61","volume-title":"Magnetic resonance imaging of cells in experimental disease models","author":"Muja","year":"2009","journal-title":"Prog Nucl Magn Reson Spectrosc"},{"key":"key-10.4103\/2394-8108.192521-32","first-page":"15256","volume-title":"Neurotransplantation of magnetically labeled oligodendrocyte progenitors: Magnetic resonance tracking of cell migration and myelination","author":"Bulte","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key-10.4103\/2394-8108.192521-33","first-page":"484","volume-title":"Iron oxide MR contrast agents for molecular and cellular imaging","author":"Bulte","year":"2004","journal-title":"NMR Biomed"},{"key":"key-10.4103\/2394-8108.192521-34","first-page":"261","volume-title":"Applicability and limitations of MR tracking of neural stem cells with asymmetric cell division and rapid turnover: The case of the shiverer dysmyelinated mouse brain","author":"Walczak","year":"2007","journal-title":"Magn Reson Med"},{"key":"key-10.4103\/2394-8108.192521-35","first-page":"514","volume-title":"The effects of clinically used MRI contrast agents on the biological properties of human mesenchymal stem cells","author":"Kim","year":"2010","journal-title":"NMR Biomed"},{"key":"key-10.4103\/2394-8108.192521-36","first-page":"513","volume-title":"Feridex labeling of mesenchymal stem cells inhibits chondrogenesis but not adipogenesis or osteogenesis","author":"Kostura","year":"2004","journal-title":"NMR Biomed"},{"key":"key-10.4103\/2394-8108.192521-37","first-page":"1076","volume-title":"Effects of iron oxide incorporation for long term cell tracking on MSC differentiation in vitro and in vivo","author":"Farrell","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"key-10.4103\/2394-8108.192521-38","first-page":"272","volume-title":"The inhibitory effect of superparamagnetic iron oxide nanoparticle (Ferucarbotran) on osteogenic differentiation and its signaling mechanism in human mesenchymal stem cells","author":"Chen","year":"2010","journal-title":"Toxicol Appl Pharmacol"},{"key":"key-10.4103\/2394-8108.192521-39","first-page":"307","volume-title":"Magnetic resonance contrast and biological effects of intracellular superparamagnetic iron oxides on human mesenchymal stem cells with long-term culture and hypoxic exposure","author":"Rosenberg","year":"2013","journal-title":"Cytotherapy"},{"key":"key-10.4103\/2394-8108.192521-40","first-page":"423","volume-title":"Magnetic nanoparticles as markers for cellular MR imaging","author":"Bulte","year":"2005","journal-title":"J Magn Magn Mater"},{"key":"key-10.4103\/2394-8108.192521-41","first-page":"167","volume-title":"Superparamagnetic iron oxide: Pharmacokinetics and toxicity","author":"Weissleder","year":"1989","journal-title":"AJR Am J Roentgenol"},{"key":"key-10.4103\/2394-8108.192521-42","first-page":"07B314","volume-title":"Labeling of human mesenchymal stem cell: Comparison between paramagnetic and superparamagnetic agents","author":"Yang","year":"2009","journal-title":"J Appl Phys"},{"key":"key-10.4103\/2394-8108.192521-43","first-page":"1191","volume-title":"Study of apoptosis in labeled mesenchymal stem cells with superparamagnetic iron oxide using neutral comet assay","author":"Omidkhoda","year":"2007","journal-title":"ToxicolIn Vitro"},{"key":"key-10.4103\/2394-8108.192521-44","first-page":"4861","volume-title":"Heparin-coated superparamagnetic iron oxide for in vivo MR imaging of human MSCs","author":"Lee","year":"2012","journal-title":"Biomaterials"},{"key":"key-10.4103\/2394-8108.192521-45","first-page":"84","volume-title":"Therapeutic time window of mesenchymal stem cells derived from bone marrow after cerebral ischemia","author":"Komatsu","year":"2010","journal-title":"Brain Res"},{"key":"key-10.4103\/2394-8108.192521-46","first-page":"L760","volume-title":"Human mesenchymal stem cells suppress chronic airway inflammation in the murine ovalbumin asthma model","author":"Bonfield","year":"2010","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"key-10.4103\/2394-8108.192521-47","first-page":"51","volume-title":"Defining human mesenchymal stem cell efficacy in vivo","author":"Bonfield","year":"2010","journal-title":"J Inflamm (Lond)"},{"key":"key-10.4103\/2394-8108.192521-48","first-page":"312","volume-title":"Detection threshold of single SPIO-labeled cells with FIESTA","author":"Heyn","year":"2005","journal-title":"Magn Reson Med"},{"key":"key-10.4103\/2394-8108.192521-49","first-page":"52","volume-title":"Application of the static dephasing regime theory to superparamagnetic iron-oxide loaded cells","author":"Bowen","year":"2002","journal-title":"Magn Reson Med"},{"key":"key-10.4103\/2394-8108.192521-50","first-page":"1334","volume-title":"Surface functionalization of single superparamagnetic iron oxide nanoparticles for targeted magnetic resonance imaging","author":"Amstad","year":"2009","journal-title":"Small"},{"key":"key-10.4103\/2394-8108.192521-51","first-page":"381","volume-title":"Antimyosin-labeled monocrystalline iron oxide allows detection of myocardial infarct: MR antibody imaging","author":"Weissleder","year":"1992","journal-title":"Radiology"},{"key":"key-10.4103\/2394-8108.192521-52","first-page":"245","volume-title":"Polyclonal human immunoglobulin G labeled with polymeric iron oxide: Antibody MR imaging","author":"Weissleder","year":"1991","journal-title":"Radiology"},{"key":"key-10.4103\/2394-8108.192521-53","first-page":"103","volume-title":"Detection of single mammalian cells by high-resolution magnetic resonance imaging","author":"Dodd","year":"1999","journal-title":"Biophys J"},{"key":"key-10.4103\/2394-8108.192521-54","first-page":"148","volume-title":"Specific MR imaging of human lymphocytes by monoclonal antibody-guided dextran-magnetite particles","author":"Bulte","year":"1992","journal-title":"Magn Reson Med"},{"key":"key-10.4103\/2394-8108.192521-55","first-page":"480","volume-title":"Clinically applicable labeling of mammalian and stem cells by combining superparamagnetic iron oxides and transfection agents","author":"Frank","year":"2003","journal-title":"Radiology"},{"key":"key-10.4103\/2394-8108.192521-56","first-page":"32","volume-title":"Selective MR imaging of labeled human peripheral blood mononuclear cells by liposome mediated incorporation of dextran-magnetite particles","author":"Bulte","year":"1993","journal-title":"Magn Reson Med"},{"key":"key-10.4103\/2394-8108.192521-57","first-page":"S301","volume-title":"Tagging of T cells with superparamagnetic iron oxide: Uptake kinetics and relaxometry","author":"Bulte","year":"1996","journal-title":"Acad Radiol"},{"key":"key-10.4103\/2394-8108.192521-58","first-page":"1","volume-title":"Magnetic resonance imaging contrast agents: Overview and perspectives","author":"Yan","year":"2006","journal-title":"Radiography"},{"key":"key-10.4103\/2394-8108.192521-59","first-page":"195","volume-title":"Cytotoxic effects of iron oxide nanoparticles and implications for safety in cell labelling","author":"Soenen","year":"2011","journal-title":"Biomaterials"},{"key":"key-10.4103\/2394-8108.192521-60","first-page":"3645","volume-title":"The promotion of human mesenchymal stem cell proliferation by superparamagnetic iron oxide nanoparticles","author":"Huang","year":"2009","journal-title":"Biomaterials"},{"key":"key-10.4103\/2394-8108.192521-61","first-page":"838","volume-title":"Characterization of biophysical and metabolic properties of cells labeled with superparamagnetic iron oxide nanoparticles and transfection agent for cellular MR imaging","author":"Arbab","year":"2003","journal-title":"Radiology"},{"key":"key-10.4103\/2394-8108.192521-62","first-page":"e11462","volume-title":"Superparamagnetic iron oxide nanoparticles labeling of bone marrow stromal (mesenchymal) cells does not affect their \u201cstemness\u201d","author":"Balakumaran","year":"2010","journal-title":"PLoS One"},{"key":"key-10.4103\/2394-8108.192521-63","first-page":"919","volume-title":"Effects of MRI contrast agents on the stem cell phenotype","author":"Crabbe","year":"2010","journal-title":"Cell Transplant"},{"key":"key-10.4103\/2394-8108.192521-64","first-page":"211","volume-title":"In vivo tracking of mesenchymal stem cells labeled with a novel chitosan-coated superparamagnetic iron oxide nanoparticles using 3.0T MRI","author":"Reddy","year":"2010","journal-title":"J Korean Med Sci"},{"key":"key-10.4103\/2394-8108.192521-65","first-page":"252","volume-title":"Perfusion regulation of hMSC microenvironment and osteogenic differentiation in 3D scaffold","author":"Kim","year":"2012","journal-title":"Biotechnol Bioeng"},{"key":"key-10.4103\/2394-8108.192521-66","first-page":"3154","volume-title":"Unexpected severe calcification after transplantation of bone marrow cells in acute myocardial infarction","author":"Yoon","year":"2004","journal-title":"Circulation"},{"key":"key-10.4103\/2394-8108.192521-67","first-page":"200","volume-title":"MR evaluation of the glomerular homing of magnetically labeled mesenchymal stem cells in a rat model of nephropathy","author":"Hauger","year":"2006","journal-title":"Radiology"},{"key":"key-10.4103\/2394-8108.192521-68","first-page":"1451","volume-title":"Dynamic imaging of allogeneic mesenchymal stem cells trafficking to myocardial infarction","author":"Kraitchman","year":"2005","journal-title":"Circulation"},{"key":"key-10.4103\/2394-8108.192521-69","first-page":"1569","volume-title":"Dual-modality monitoring of targeted intraarterial delivery of mesenchymal stem cells after transient ischemia","author":"Walczak","year":"2008","journal-title":"Stroke"}],"container-title":["Brain Circulation"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:33:58Z","timestamp":1786714438000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/2394-8108.192521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":69,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016]]}},"alternative-id":["192521"],"URL":"https:\/\/doi.org\/10.4103\/2394-8108.192521","relation":{},"ISSN":["2394-8108"],"issn-type":[{"value":"2394-8108","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]}}}