{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:19:44Z","timestamp":1787847584228,"version":"build-2784847793"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVES:<\/jats:title>\n                    <jats:p>Despite the acute and life-threatening repercussions that tuberculosis (TB) may have on the burgeoning older population in endemic countries like India, the spectrum of geriatric TB emergencies is not adequately understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>We performed a prospective observational study at the emergency department of an academic hospital in north India between January 2019 and June 2020, investigating the clinical and laboratory features and outcomes of active TB in older patients aged 60 years and above.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Out of 71 geriatric TB emergencies, central nervous system disease predominated (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 41, 57.7%), followed by pulmonary (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 16, 22.5%), pleural TB (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 8, 11.3%), and multisite involvement (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 6, 8.4%). Nearly 71.8% were male, and 77.4% belonged to low socioeconomic status (lower-middle or lower class). Usual predisposing factors were tobacco smoking (38.0%), chronic alcohol use (27.0%), and diabetes mellitus (23.9%). Atypical features were more frequent with extrapulmonary TB. Only 28.2% were microbiologically confirmed cases, and rifampicin resistance was seen in only one case. The mortality rate was considerably high (24.0%), highest with pulmonary TB (37.0%).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>Older patients with TB emergencies have atypical presentations, diagnostic difficulties, and high mortality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/2452-2473.320800","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T00:39:06Z","timestamp":1625618346000},"page":"91-97","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":12,"title":["Clinical spectrum and outcomes of geriatric tuberculosis emergencies in North India"],"prefix":"10.4103","volume":"21","author":[{"given":"Nadim","family":"Rahman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Sethi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Saroch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Behera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Bhalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandeep","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok Kumar","family":"Pannu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R2-1-20240909","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.cger.2016.02.006","article-title":"Tuberculosis in Older Adults","volume":"32","author":"Rajagopalan","year":"2016","journal-title":"Clin Geriatr Med"},{"key":"R3-1-20240909","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.idc.2010.04.011","article-title":"Tuberculosis in the global aging population","volume":"24","author":"Mori","year":"2010","journal-title":"Infect Dis Clin North Am"},{"key":"R5-1-20240909","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s12890-018-0627-3","article-title":"Potential effect of household environment on prevalence of tuberculosis in India: Evidence from the recent round of a cross-sectional survey","volume":"18","author":"Singh","year":"2018","journal-title":"BMC Pulm Med"},{"key":"R6-1-20240909","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1016\/S0140-6736(10)60580-6","article-title":"Age and the epidemiology and pathogenesis of tuberculosis","volume":"375","author":"Donald","year":"2010","journal-title":"Lancet"},{"key":"R8-1-20240909","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1046\/j.1532-5415.2002.50307.x","article-title":"Unrecognized tuberculosis in a nursing home causing death with spread of tuberculosis to the community","volume":"50","author":"Ijaz","year":"2002","journal-title":"J Am Geriatr Soc"},{"key":"R9-1-20240909","doi-asserted-by":"crossref","first-page":"e67288","DOI":"10.1371\/journal.pone.0067288","article-title":"The profile and treatment outcomes of the older (aged 60 years and above) tuberculosis patients in Tamilnadu, South India","volume":"8","author":"Ananthakrishnan","year":"2013","journal-title":"PLoS One"},{"key":"R10-1-20240909","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/ageing\/22.4.289","article-title":"The association of age with the presentation and outcome of tuberculosis: A five-year survey","volume":"22","author":"Teale","year":"1993","journal-title":"Age Ageing"},{"key":"R12-1-20240909","first-page":"448","article-title":"Index-TB guidelines: Guidelines on extrapulmonary tuberculosis for India","volume":"145","author":"Sharma","year":"2017","journal-title":"Indian J Med Res"},{"key":"R13-1-20240909","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18231\/2394-6776.2019.0001","article-title":"Modified Kuppuswamy socioeconomic scale updated for the year 2019","volume":"6","author":"Saleem","year":"2019","journal-title":"Indian J Forensic Community Med"},{"key":"R14-1-20240909","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1378\/chest.116.4.961","article-title":"Does aging modify pulmonary tuberculosis. 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