{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T15:34:34Z","timestamp":1787758474625,"version":"build-2784847793"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>OBJECTIVES:<\/jats:title>\n                    <jats:p>Evaluating local trends and continued monitoring of patterns of acute poisoning are essential for prompt recognition of the toxidromes, the establishment of immediate treatment facilities (e.g., antidote availability), and effective preventive strategies (e.g., governmental regulation on hazardous substances marketing). We aimed to describe the prevalence of the various types of poisoning and associated case fatality in our academic hospital in North India.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS:<\/jats:title>\n                    <jats:p>A prospective observational descriptive study was conducted, enrolling patients aged \u226513 years with acute poisoning for 17 months from December 2016 to December 2017 and from September 2019 to December 2019, for a total of 17 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS:<\/jats:title>\n                    <jats:p>\n                      Four hundred and two patients were enrolled (median age 28 years; 63.2% males). Majority of the acute poisoning cases resulted from ingestion (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 391, 97.3%) and the primary intention was most commonly self-harm (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 314, 78.1%). The major types of poisoning were pesticide (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 264, 65.7%), drug overdose (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 77, 19.2%), and corrosive ingestion (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 31, 7.7%). Pesticides included insecticides (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 146, 36.3%; cholinesterase inhibitors,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 91), fungicides (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 76, 18.9%; all aluminum phosphide), herbicides (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 22, 5.5%; paraquat,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 19), and rodenticides (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 20, 5.0%; coumarin-derived substances,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 12). Benzodiazepines (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 33) and opioids (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 25) were frequent causes of drug overdose. 95.3% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 379) received preliminary treatment at the previous health-care center, including gastric lavage (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 239) and antidotes (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 73). In-hospital case fatality rate was 17.3% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 58).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION:<\/jats:title>\n                    <jats:p>Herbicide ingestion and opioid overdose are emerging threats with a gradual decline in organophosphate and aluminum phosphide poisoning. Despite improving management of acute poisoning, the overall case fatality rate remains substantial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/2452-2473.357627","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T14:29:35Z","timestamp":1664461775000},"page":"192-199","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":17,"title":["Changing spectrum of acute poisoning in North India"],"prefix":"10.4103","volume":"22","author":[{"given":"Ashok Kumar","family":"Pannu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Bhalla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitla","family":"Vamshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish 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