{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T14:10:16Z","timestamp":1724681416604},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n            <jats:title>Abstract<\/jats:title>\n            <jats:p>The global coronavirus disease-19 (COVID-19) pandemic, caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2), has created an unprecedented, global public health crisis. Epidemiological studies showed that hypertension is a frequent comorbidity, as well as an independent prognostic risk factor in patients with COVID-19. Angiotensin-converting enzyme-2 (ACE-2) is a receptor for SARS-CoV-2, and thus essential for viral entry into human cells. This review summarizes the recent findings of epidemiology of hypertension in COVID-19 patients and highlights the critical role of ACE2. We also review the impact of endothelial dysfunction, inflammation, and arterial stiffness in promoting hypertension and cardiovascular disease in COVID-19 patients. This review also discusses therapeutic strategies for managing hypertension in patients with COVID-19, with particular emphasis on ACE inhibitors, angiotensin receptor blockers, and calcium channel blockers.<\/jats:p>\n          <\/jats:sec>","DOI":"10.4103\/2470-7511.334397","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T10:06:50Z","timestamp":1640858810000},"page":"210-217","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Management of Hypertension in Patients with COVID-19: Implication of Angiotensin-Converting Enzyme 2"],"prefix":"10.1097","volume":"6","author":[{"given":"Guang-Hong","family":"Jia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"Sowers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Cardiology Plus"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.4103\/2470-7511.334397","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T13:19:47Z","timestamp":1724678387000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.4103\/2470-7511.334397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.4103\/2470-7511.334397","relation":{},"ISSN":["2470-752X"],"issn-type":[{"type":"print","value":"2470-752X"}],"subject":[],"published":{"date-parts":[[2021,10]]}}}