{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T08:45:42Z","timestamp":1782981942167,"version":"3.54.5"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acute pancreatitis is increasingly recognized as a condition with long-term metabolic consequences, including the development of diabetes mellitus (DM) after recovery. Post-Pancreatitis Diabetes Mellitus (PPDM), a form of diabetes of the exocrine pancreas, arises due to complex interactions between pancreatic inflammation, \u03b2-cell injury, insulin resistance, and hormonal dysregulation. Identifying patients at risk for diabetes following acute pancreatitis remains challenging, as conventional glucose-based diagnostic methods detect dysglycemia only after significant endocrine dysfunction has occurred. C-peptide, a by-product of endogenous insulin synthesis, serves as a stable and reliable marker of pancreatic \u03b2-cell function and insulin secretory reserve. Unlike insulin, C-peptide is minimally affected by hepatic clearance and has a longer half-life, making it particularly useful for assessing residual endocrine function. This narrative review explores the physiological basis of C-peptide production, its measurement techniques, and its clinical relevance in differentiating insulin resistance from true insulin deficiency. The review also summarizes current evidence supporting the role of C-peptide in risk stratification, disease classification, and prediction of diabetes progression following acute pancreatitis. Incorporating C-peptide assessment into postpancreatitis follow-up protocols may allow earlier identification of high-risk individuals, facilitate personalized management strategies, and improve long-term glycemic outcomes. Further prospective studies are needed to establish standardized timing and clinically relevant cutoff values for C-peptide measurement in this population.<\/jats:p>","DOI":"10.4103\/aam.aam_106_26","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T08:00:37Z","timestamp":1782979237000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["The Role of C-peptide in Predicting Diabetes Mellitus after Acute Pancreatitis: A Narrative Review"],"prefix":"10.4103","author":[{"given":"Chandan","family":"Sanga","sequence":"first","affiliation":[{"name":"Department of General Surgery, Shri Sathya Sai Medical College and Research Institute, Sri Balaji Vidyapeeth (Deemed to be University), Kancheepuram, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Naren","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Shri Sathya Sai Medical College and Research Institute, Sri Balaji Vidyapeeth (Deemed to be University), Kancheepuram, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,7,2]]},"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.4103\/aam.aam_106_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T08:00:37Z","timestamp":1782979237000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.4103\/aam.aam_106_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,2]]},"references-count":0,"URL":"https:\/\/doi.org\/10.4103\/aam.aam_106_26","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,2]]},"assertion":[{"value":"2026-02-01","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-14","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}