{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T20:21:58Z","timestamp":1787775718040,"version":"build-2784847793"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n                    <jats:title>The Aim of the Present Study:<\/jats:title>\n                    <jats:p>The aim of the present study was to do a comparison of the recovery profiles and airway-related adverse events of pediatric magnetic resonance imaging (MRI) sedation patients who received propofol alone to those who received midazolam alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective cohort study was approved by the Mutah University Ethical Approval Committee (No. 2378). A search of the patients\u2019 medical records was performed between September 2021 and April 2022 to identify children aged 4 months\u201311 years who received propofol or midazolam for MRI sedation. The patients were subdivided into two groups: Those who had propofol alone (propofol group) and those who received midazolam (midazolam group) for pediatric MRI sedation. In propofol group, a 1\u20132 mg\/kg of propofol bolus was given to have a deep sedation (Ramsay Sedation Scale score of 5). Patients in midazolam group received 0.05 mg\/kg of midazolam. During the maintenance state of sedation, the patient received 150 \u00b5g\/kg\/min of propofol, and the infusion rate was adjusted in 25 \u03bcg\/kg\/min increments up or down at the discretion of the anesthesiologists to maintain a state of deep sedation. The major targets of this study were recovery profiles (time to awake and time to discharge) and airway-related intervention ratios in pediatric MRI sedation patients. Patient demographics, MRI sedation, and recovery data, including propofol induction dose, airway intervention, and sedation-related adverse events from the pediatric sedation recovery unit were also collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The mean (standard deviation [SD]) propofol induction dose was higher compared to midazolam group (2.4 [0.7] mg vs. 1.3 [0.5] mg; mean difference, 1.1 mg;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). The mean (SD) infusion rate was higher in propofol group compared to midazolam group (161.3 [37.6] \u03bcg\/min\/kg vs. 116.2 [25.6] \u03bcg\/min\/kg; mean difference 45.1 \u03bcg\/min\/kg;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). The mean (SD) propofol total dose was higher in propofol group compared to midazolam group (236.3 [102.4] mg vs. 180.7 [80.9] mg; mean difference, 155.4 mg;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). The mean (SD) time to awake was longer in midazolam group compared to propofol group (21.2 [5.6] min vs. 23.0 [7.1] min; mean difference, 1.8 min;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). The mean (SD) time to discharge was longer in midazolam group compared to propofol group (34.5 [6.9] min vs. 38.6 [9.4] min; mean difference, 4.1 min; 95% confidence interval, 3.0\u20135.1;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The administration of midazolam during pediatric MRI sedation can decrease the frequency of airway complications without prolonging the clinically significant recovery profile.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aam.aam_109_23","type":"journal-article","created":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T01:00:22Z","timestamp":1726448422000},"page":"669-673","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["A Comparison of the Use of Propofol versus Midazolam for Pediatric Magnetic Resonance Imaging Sedation: Retrospective Cohort Study"],"prefix":"10.4103","volume":"23","author":[{"given":"Mohammed I. A.","family":"Ismail","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Mut\u2019ah School of Medicine, Al-Karak, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf","family":"Aldmour","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Mut\u2019ah School of Medicine, Al-Karak, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lou\u2019i","family":"Al-Husinat","sequence":"additional","affiliation":[{"name":"Department of Clinical Medical Sciences, Faculty of Medicine, Yarmouk University, Irbid, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gehane A.","family":"El-Gendy","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Mut\u2019ah School of Medicine, Al-Karak, Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif W.","family":"Mansour","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, 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Pregl"},{"key":"R13-20260427","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1213\/ANE.0000000000002021","article-title":"The effect of sedation on cortical activation: A randomized study comparing the effects of sedation with midazolam, propofol, and dexmedetomidine on auditory processing","volume":"124","author":"Fr\u00f6lich","year":"2017","journal-title":"Anesth Analg"},{"key":"R14-20260427","doi-asserted-by":"crossref","first-page":"e67","DOI":"10.1016\/j.jemermed.2014.09.062","article-title":"Successful flumazenil reversal of paradoxical reaction to midazolam in a child","volume":"48","author":"Jackson","year":"2015","journal-title":"J Emerg Med"},{"key":"R15-20260427","doi-asserted-by":"crossref","first-page":"9","DOI":"10.4097\/kjae.2013.65.1.9","article-title":"The effect of midazolam dose and age on the paradoxical midazolam reaction in Korean pediatric patients","volume":"65","author":"Shin","year":"2013","journal-title":"Korean J Anesthesiol"}],"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_109_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:40:25Z","timestamp":1787773225000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_109_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,14]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/aam.aam_109_23","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,14]]},"assertion":[{"value":"2023-07-07","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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