{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:38:06Z","timestamp":1787841486992,"version":"build-2784847793"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:p>Nitrofurantoin is the antibiotic of choice for treatment and prophylaxis of recurrent episodes of lower urinary tract infections. Although adverse effects such as anorexia, vomiting, and pulmonary hypersensitivity are commonly reported with nitrofurantoin use, studies have demonstrated that rarely nitrofurantoin can also induce diverse forms of liver injury, spanning from mild hepatitis to severe and potentially fatal fulminant liver failure. These occur especially in elderly females with preexisting liver or renal impairment. Here, we present a case of a 62-year-old female in good health who exhibited symptoms of fatigue, abdominal pain, and dark-colored urine. Through investigation, she was diagnosed with a case of drug-induced liver injury associated with the prolonged use of nitrofurantoin.<\/jats:p>","DOI":"10.4103\/aam.aam_113_23","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T02:09:11Z","timestamp":1721614151000},"page":"514-517","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Drug-induced Liver Injury Following Prolonged use of Nitrofurantoin"],"prefix":"10.4103","volume":"23","author":[{"given":"Manthan","family":"Dhingra","sequence":"first","affiliation":[{"name":"Department of General Medicine, Dayanand Medical College and Hospital, Ludhiana, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhra","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Dayanand Medical College and Hospital, Ludhiana, Punjab, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,7,20]]},"reference":[{"key":"R1-20260507","article-title":"Nitrofurantoin (PIM 377)"},{"key":"R2-20260507","doi-asserted-by":"crossref","first-page":"342","DOI":"10.46747\/cfp.6705342","article-title":"Nitrofurantoin-induced liver failure: A fatal yet forgotten complication","volume":"67","author":"Luk","year":"2021","journal-title":"Can Fam Physician"},{"key":"R3-20260507","doi-asserted-by":"crossref","first-page":"bcr2013203136","DOI":"10.1136\/bcr-2013-203136","article-title":"Nitrofurantoin immune-mediated drug-induced liver injury: A serious complication of a commonly prescribed medication","volume":"2014","author":"Hydes","year":"2014","journal-title":"BMJ Case Rep"},{"key":"R5-20260507","first-page":"e26882","article-title":"An unusual case of drug-induced liver injury secondary to nitrofurantoin use","volume":"14","author":"Wonnacott","year":"2022","journal-title":"Cureus"},{"key":"R7-20260507","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.cld.2013.07.002","article-title":"Mechanisms of drug-induced liver injury","volume":"17","author":"Yuan","year":"2013","journal-title":"Clin Liver Dis"},{"key":"R8-20260507","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/hep.20800","article-title":"Outcome and prognostic markers in severe drug-induced liver disease","volume":"42","author":"Bj\u00f6rnsson","year":"2005","journal-title":"Hepatology"},{"key":"R9-20260507","first-page":"73","article-title":"Drug-induced liver injury","volume":"6","author":"David","year":"2010","journal-title":"US Gastroenterol Hepatol Rev"},{"key":"R11-20260507","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0005-2728(88)90261-7","article-title":"Mechanism of nitrofurantoin toxicity and oxidative stress in mitochondria","volume":"936","author":"Carbonera","year":"1988","journal-title":"Biochim Biophys Acta"}],"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_113_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:57:48Z","timestamp":1787839068000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_113_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.4103\/aam.aam_113_23","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"2023-07-11","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-03","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}