{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:46:09Z","timestamp":1791812769425,"version":"4.3.4"},"reference-count":6,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 3","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mycoplasma-induced rash and mucositis (MIRM) is a recently recognized mucocutaneous disorder, often misdiagnosed as Stevens\u2013Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), or erythema multiforme (EM). We report a 6-year-old boy presenting with fever, cough, and cold, followed by painful oral ulcerations, conjunctivitis, genital mucositis, and generalized vesiculobullous rash. He was on levetiracetam for a prior unprovoked seizure, raising suspicion of drug reaction. Initial differentials included SJS, TEN, EM, and Drug reaction with eosinophilia and systemic symptoms. Laboratory findings showed leukocytosis, thrombocytosis, and positive Mycoplasma pneumoniae Immunoglobulin M, while Herpes simplex virus polymerase chain reaction was negative. Histopathology revealed liquefactive necrosis with lymphohistiocytic infiltrates. Despite intravenous antibiotics, antivirals, and immunoglobulin, there was no improvement until pulse methylprednisolone was initiated. He was discharged on tapering oral steroids and doxycycline, with complete mucosal healing on follow-up. As there is no clear-cut distinction between histopathological findings of EM and MIRM, reporting biopsy changes whenever feasible is essential. Early recognition, targeted antibiotics, and timely immunomodulation are key to favorable outcomes.<\/jats:p>","DOI":"10.4103\/aam.aam_115_26","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:21:34Z","timestamp":1782850894000},"page":"S525-S527","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Mycoplasma-induced Rash and Mucositis: A Distinct Pediatric Entity from India"],"prefix":"10.4103","volume":"25","author":[{"given":"Ramees Fathima","family":"Shamsuddin","sequence":"first","affiliation":[{"name":"SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology (Deemed to be University), Kattankulathur, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasanna","family":"Raju","sequence":"additional","affiliation":[{"name":"SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology (Deemed to be University), Kattankulathur, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vimalraj","family":"Vijayakumar","sequence":"additional","affiliation":[{"name":"SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology (Deemed to be University), Kattankulathur, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sugapriya","family":"Paranjothi","sequence":"additional","affiliation":[{"name":"SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology (Deemed to be University), Kattankulathur, Tamil Nadu, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"R1-20261012","doi-asserted-by":"crossref","first-page":"bcr2017220749","DOI":"10.1136\/bcr-2017-220749","article-title":"Mycoplasma pneumoniae-induced rash and mucositis (MIRM): An unusual mild skin rash associated with severe mucosal involvement","volume":"2017","author":"Poddighe","year":"2017","journal-title":"BMJ Case Rep"},{"key":"R2-20261012","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1128\/CMR.17.4.697-728.2004","article-title":"Mycoplasma pneumoniae and its role as a human pathogen","volume":"17","author":"Waites","year":"2004","journal-title":"Clin Microbiol Rev"},{"key":"R3-20261012","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jaad.2014.06.026","article-title":"Mycoplasma pneumoniae-induced rash and mucositis as a syndrome distinct from Stevens-Johnson syndrome and erythema multiforme: A systematic review","volume":"72","author":"Canavan","year":"2015","journal-title":"J Am Acad Dermatol"},{"key":"R4-20261012","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3389\/fmicb.2016.00023","article-title":"Classification of extrapulmonary manifestations due to Mycoplasma pneumoniae infection on the basis of possible pathogenesis","volume":"7","author":"Narita","year":"2016","journal-title":"Front Microbiol"},{"key":"R6-20261012","doi-asserted-by":"crossref","first-page":"472474","DOI":"10.1007\/s12098-021-03658-z","article-title":"Mycoplasma-induced rash and mucositis or Steven-Johnson syndrome","volume":"88","author":"Thangaraju","year":"2021","journal-title":"Indian J Pediatr"},{"key":"R7-20261012","first-page":"2407","article-title":"The spectrum of mucocutaneous disease associated with Mycoplasma pneumoniae infection","volume":"35","author":"Meyer Sauteur","year":"2021","journal-title":"J Eur Acad Dermatol Venereol"}],"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_115_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:01:34Z","timestamp":1791810094000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_115_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":6,"journal-issue":{"issue":"Suppl 3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/aam.aam_115_26","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,30]]},"assertion":[{"value":"2026-02-04","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-22","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}