{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:59:22Z","timestamp":1790067562995,"version":"4.0.1"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,11]]},"abstract":"Abstract<\/jats:title>\n \n Context:<\/jats:title>\n Dexmedetomidine has been used as an adjuvant to minimize the adverse effects associated with opioids, either in the form of intravenous injection or intravenous infusion.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n The present study aimed to compare the efficacy of dexmedetomidine when administered via intravenous infusion and intravenous bolus injection.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n A comparative observational study was conducted among 1000 participants aged 35\u201365 years with American Society of Anesthesiologists physical status I\/II, scheduled to undergo elective gynecological surgeries. Participants were divided into Group D (received a loading dose of bolus 0.5 \u00b5g\/kg, followed by 0.3 \u00b5g\/kg\/h intravenous infusion of dexmedetomidine) and Group C (control group) 15 min before the induction of anesthesia. Hemodynamic variables, recovery time, rescue analgesia, pain scores, and any adverse events were recorded.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Participants in Group D had lower hemodynamic parameters (after 1 h till the end of surgery) (\n P<\/jats:italic>\n < 0.05). Participants in Group D took fewer rescue analgesics compared to Group C (\n P<\/jats:italic>\n = 0.001), and recovery time was prolonged in Group D (\n P<\/jats:italic>\n = 0.001). Pain scores were lower in Group D compared to Group C (\n P<\/jats:italic>\n = 0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n A loading dose of intravenous bolus followed by intravenous infusion of dexmedetomidine is a valuable adjunct in the perioperative management of such patients, offering potential benefits in enhancing recovery and reducing the need for postsurgical analgesia.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/aam.aam_116_26","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T15:22:56Z","timestamp":1781018576000},"page":"1441-1448","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Intraoperative Intravenous Dexmedetomidine on Postoperative Analgesia among Patients following Gynecological Surgeries \u2013 A Comparative Observational Study"],"prefix":"10.4103","volume":"25","author":[{"given":"N. Gary","family":"Renil","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaila S.","family":"Kamath","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi R.","family":"Aithal","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shodhan Rao","family":"Pejavar","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine and Toxicology, A. J. Institute of Medical Sciences and Research Centre, Mangalore, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"R1-20260922","first-page":"103312","article-title":"Pharmacologic and non-pharmacologic labor pain management techniques in a resource-limited setting: A systematic review","volume":"74","author":"Beyable","year":"2022","journal-title":"Ann Med Surg (Lond)"},{"key":"R2-20260922","doi-asserted-by":"crossref","first-page":"403","DOI":"10.4103\/ija.IJA_33_20","article-title":"Acute postoperative pain experiences and satisfaction with its management among patients with elective surgery: An observational study","volume":"64","author":"Sharma","year":"2020","journal-title":"Indian J Anaesth"},{"key":"R3-20260922","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/ACO.0000000000000584","article-title":"Anesthesia and analgesia for gynecological 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