{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T20:03:36Z","timestamp":1787169816600,"version":"build-2736575974"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n Osteoporosis is a common metabolic bone disorder associated with reduced bone mineral density (BMD) and increased risk of fractures and chronic pain. Zoledronic acid (ZA), a bisphosphonate, is widely used in the management of osteoporosis because of its antiresorptive properties.<\/jats:p>\n <\/jats:sec>\n \n Aims and Objectives:<\/jats:title>\n To evaluate the effect of zoledronic acid on pain levels and bone mineral density in patients with osteoporosis over a 2-year follow-up period.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n A hospital-based observational pre\u2013post study was conducted among 120 diagnosed osteoporosis patients. Each participant received a single dose of zoledronic acid and was followed for 2 years. Pain levels were assessed using the Visual Analog Scale (VAS), and BMD measurements were recorded at baseline and at structured 6-monthly intervals up to 2 years.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Participants demonstrated higher pain scores at baseline, followed by a progressive decline at 6 months, 1 year, 1.5 years, and 2 years. This decreasing trend was statistically significant (\n P<\/jats:italic>\n = 0.001). Similarly, BMD was lowest at baseline and showed a consistent increase across all follow-up intervals, with the upward trend also reaching statistical significance (\n P<\/jats:italic>\n = 0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Zoledronic acid effectively reduces osteoporosis-related pain and significantly improves bone mineral density over time in patients with osteoporosis.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/aam.aam_117_26","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T05:00:15Z","timestamp":1780981215000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Zoledronic Acid on Pain and Bone Mineral Density in Osteoporosis: A 2-year Longitudinal Study"],"prefix":"10.4103","author":[{"given":"Prem","family":"Kotian","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pranav","family":"Rajasekharan","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prafulla","family":"Gadwal","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prananshu","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archith","family":"Boloor","sequence":"additional","affiliation":[{"name":"Department of Medicine, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajendra","family":"Annappa","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keerthan Ranga","family":"Nayak","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Premjit","family":"Sujir","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,6,8]]},"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_117_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:13:38Z","timestamp":1787166818000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_117_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,8]]},"references-count":0,"URL":"https:\/\/doi.org\/10.4103\/aam.aam_117_26","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,8]]},"assertion":[{"value":"2026-02-04","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-22","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}