{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:34:15Z","timestamp":1787762055358,"version":"build-2784847793"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Venous thromboembolism (VTE) commonly presents as either deep-vein thrombosis (DVT) or pulmonary embolism (PE). Despite rapid advances in its diagnostic and therapeutic modalities, it still leads to significant morbidity and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>Our study predominantly aims at studying the clinical profile, risk factors, and the clinical outcomes in VTE patients presenting to a single tertiary care center to rapidly detect the disease and use appropriate thrombo-prophylaxis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>This was an prospective observational study involving 40 patients of confirmed cases of VTE who presented to this tertiary care hospital during a period from June 2017 to May 2019. Data collected included the age, sex, clinical presentation, risk factors, diagnostic modalities, and their clinical outcomes. Descriptive analysis was carried out by mean and standard deviation for quantitative variables; frequency and proportion for the categorical variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Among the study groups, 30 (74%) had DVT, 4 (11%) had PE, and 6 (15%) had both. Major risk factors detected included smoking history (44%), recent surgery (15%), malignancy (11%), history of immobility (10%), and past history of DVT (15%). The clinical presentation mainly included leg pain (62%) and leg swelling (87%). The outcomes were predominantly re-canalization (31%), recurrent DVT (21%), recurrent PE (1%), chronic DVT (27%), chronic venous insufficiency (36%), chronic venous ulcer (7%), pulmonary hypertension (16%), and death (5%). In our study population, the most common pro-thrombotic state was found to be hyperhomocysteinemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>In our study of VTE patients, we have highlighted the possible risk factors, clinical presentation, and clinical outcomes to identify the disease early and help us initiate appropriate thromboprophylaxis to reduce morbidity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aam.aam_123_22","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T02:06:24Z","timestamp":1689818784000},"page":"415-419","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Profile, Risk Factors, and Clinical Outcomes in Patients of Venous Thromboembolism at a Tertiary Care Center"],"prefix":"10.4103","volume":"22","author":[{"given":"M. A.","family":"Khan","sequence":"first","affiliation":[{"name":"Department of Medicine, Command Hospital Air Force, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Mahaboob","family":"Pasha","sequence":"additional","affiliation":[{"name":"Department of Medicine, Command Hospital Air Force, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. N.","family":"Arjun","sequence":"additional","affiliation":[{"name":"Department of Medicine and Rheumatology, Command Hospital Air Force, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narayanan","family":"Subramanian","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Command Hospital Air Force, Bengaluru, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,7,20]]},"reference":[{"key":"R1-20260512","first-page":"166","article-title":"Venous thrombosis: On the history of Virchow\u2019s triad","volume":"81","author":"Dickson","year":"2004","journal-title":"Univ Toronto Med J"},{"key":"R2-20260512","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1365-2141.2008.07323.x","article-title":"Virchow and his triad: A question of attribution","volume":"143","author":"Bagot","year":"2008","journal-title":"Br J Haematol"},{"key":"R3-20260512","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1111\/j.1365-2141.2010.08206.x","article-title":"Risk factors for venous thrombosis \u2013 Current understanding from an epidemiological point of view","volume":"149","author":"Lijfering","year":"2010","journal-title":"Br J Haematol"},{"key":"R4-20260512","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2010.01.057","article-title":"Risk factors for venous thromboembolism","volume":"56","author":"Goldhaber","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"R5-20260512","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1055\/s-0037-1616205","article-title":"Genetic approach to thrombophilia","volume":"86","author":"Bertina","year":"2001","journal-title":"Thromb Haemost"},{"key":"R6-20260512","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1182\/blood.V92.7.2353","article-title":"Different risks of thrombosis in four coagulation defects associated with inherited thrombophilia: A study of 150 families","volume":"92","author":"Martinelli","year":"1998","journal-title":"Blood"},{"key":"R7-20260512","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nrcardio.2015.83","article-title":"Epidemiology of venous thromboembolism","volume":"12","author":"Heit","year":"2015","journal-title":"Nat Rev Cardiol"},{"key":"R9-20260512","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1055\/s-0037-1613830","article-title":"Derivation of a simple clinical model to categorize Patients probability of pulmonary embolism: Increasing the models utility with the Simplired d-dimer","volume":"83","author":"Wells","year":"2000","journal-title":"Thromb Haemost"},{"key":"R10-20260512","doi-asserted-by":"crossref","first-page":"124610","DOI":"10.5402\/2011\/124610","article-title":"Venous thromboembolism: Classification, risk factors, diagnosis, and management","volume":"2011","author":"Moheimani","year":"2011","journal-title":"ISRN Hematol"},{"key":"R11-20260512","doi-asserted-by":"crossref","first-page":"e012346","DOI":"10.1136\/bmjopen-2016-012346","article-title":"Venous thromboembolism in medical patients during hospitalisation and 3 months after hospitalisation: A prospective observational study","volume":"6","author":"Khalafallah","year":"2016","journal-title":"BMJ Open"},{"key":"R12-20260512","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.jvs.2006.10.034","article-title":"Risk factors and clinical impact of postoperative symptomatic venous thromboembolism","volume":"45","author":"Gangireddy","year":"2007","journal-title":"J Vasc Surg"},{"key":"R13-20260512","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1097\/MBC.0000000000000657","article-title":"Clinical characteristics, risk factors, and outcomes of usual and unusual site venous thromboembolism","volume":"29","author":"Koonarat","year":"2018","journal-title":"Blood Coagul Fibrinolysis"},{"key":"R14-20260512","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.thromres.2018.11.012","article-title":"Incidence, risk factors, and outcomes of venous thromboembolism after oncologic surgery: A systematic review and meta-analysis","volume":"173","author":"Li","year":"2019","journal-title":"Thromb Res"},{"key":"R15-20260512","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1177\/1538574411432145","article-title":"The risk factors and clinical outcomes of upper extremity deep vein thrombosis","volume":"46","author":"Lee","year":"2012","journal-title":"Vasc Endovascular Surg"},{"key":"R16-20260512","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1160\/TH08-06-0390","article-title":"Clinical outcome of patients with major bleeding after venous thromboembolism. 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