{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:23:37Z","timestamp":1787840617112,"version":"build-2784847793"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,5]]},"abstract":"Abstract<\/jats:title>\n \n Introduction:<\/jats:title>\n Diabetes mellitus (DM) is a chronic metabolic disorder associated with numerous complications affecting multiple organ systems. Among these, gastrointestinal (GI) symptoms are commonly observed but often underdiagnosed and undertreated. Understanding the prevalence and patterns of these symptoms in diabetic individuals is crucial for optimizing clinical management.<\/jats:p>\n <\/jats:sec>\n \n Aim:<\/jats:title>\n In this study, the frequency of GI symptoms in individuals with DM was assessed, and their relationship to antidiabetic drugs, the length of diabetes, and glycemia control was investigated.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods:<\/jats:title>\n A cross-sectional, observational study was conducted on 200 diabetic patients at a tertiary care hospital. Detailed medical histories were recorded, and participants underwent laboratory investigations, including HbA1c levels. Statistical analyses were performed to determine associations between GI symptoms and various clinical parameters.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Among the 200 participants, 67.5% reported at least one GI symptom. The most common symptoms were fecal incontinence (37%), nausea and vomiting (34.5%), abdominal bloating (33.5%), and constipation (32.5%). Poor glycemic control (HbA1c \u22659.0%) was significantly associated with increased prevalence of GI symptoms (\n P<\/jats:italic>\n < 0.01). Biguanides (metformin) were the most frequently prescribed antidiabetic drug (93%), but no significant association was found between specific oral hypoglycemia agents and GI symptoms.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n GI symptoms are highly prevalent in diabetic patients, with poor glycemic control playing a major role in their occurrence. Routine screening for GI symptoms should be incorporated into diabetes management to improve quality of life and treatment adherence.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/aam.aam_123_25","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:00:45Z","timestamp":1756378845000},"page":"579-583","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Study of Gastrointestinal Symptoms in Patients with Diabetes Mellitus"],"prefix":"10.4103","volume":"25","author":[{"given":"Sreevidya","family":"Yekkaluru","sequence":"first","affiliation":[{"name":"Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manasi","family":"Harale","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Institute, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandesh","family":"Raut","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Institute, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tushar","family":"Pancholi","sequence":"additional","affiliation":[{"name":"Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"R1-20260504","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nrendo.2017.151","article-title":"Global aetiology and epidemiology of type 2 diabetes mellitus and its complications","volume":"14","author":"Zheng","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"R2-20260504","doi-asserted-by":"crossref","first-page":"627","DOI":"10.2337\/dc17-1536","article-title":"Gastrointestinal symptoms in diabetes: Prevalence, assessment, pathogenesis, and management","volume":"41","author":"Du","year":"2018","journal-title":"Diabetes Care"},{"key":"R4-20260504","doi-asserted-by":"crossref","first-page":"378","DOI":"10.7326\/0003-4819-98-3-378","article-title":"Disorders of gastrointestinal motility associated with diabetes mellitus","volume":"98","author":"Feldman","year":"1983","journal-title":"Ann Intern Med"},{"key":"R5-20260504","first-page":"219","article-title":"Gastrointestinal signs and symptoms among persons with diabetes mellitus","volume":"4","author":"Khoshbaten","year":"2011","journal-title":"Gastroenterol Hepatol Bed Bench"},{"key":"R6-20260504","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1001\/archinte.161.16.1989","article-title":"Prevalence of gastrointestinal symptoms associated with diabetes mellitus: A population-based survey of 15,000 adults","volume":"161","author":"Bytzer","year":"2001","journal-title":"Arch Intern Med"},{"key":"R7-20260504","first-page":"1","article-title":"Gastrointestinal manifestations of diabetes: A comprehensive review of complications, mechanisms, and emerging therapeutic strategies","volume":"6","author":"Vuthaluru","year":"2024","journal-title":"J Diabetes Res Rev Rep"},{"key":"R8-20260504","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1007\/s00125-006-0354-9","article-title":"Oesophageal dysmotility, delayed gastric emptying and autonomic neuropathy correlate to disturbed glucose homeostasis","volume":"49","author":"Ohlsson","year":"2006","journal-title":"Diabetologia"},{"key":"R9-20260504","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1097\/00000478-200604000-00012","article-title":"Glycogenic hepatopathy: An underrecognized hepatic complication of diabetes mellitus","volume":"30","author":"Torbenson","year":"2006","journal-title":"Am J Surg Pathol"},{"key":"R10-20260504","first-page":"1697","article-title":"Gastrointestinal complications of diabetes","volume":"77","author":"Shakil","year":"2008","journal-title":"Am Fam Physician"},{"key":"R11-20260504","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.diabet.2010.11.002","article-title":"Metformin and digestive disorders","volume":"37","author":"Bouchoucha","year":"2011","journal-title":"Diabetes Metab"},{"key":"R12-20260504","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.2165\/00003495-199346060-00007","article-title":"Acarbose. An update of its pharmacology and therapeutic use in diabetes mellitus","volume":"46","author":"Balfour","year":"1993","journal-title":"Drugs"},{"key":"R13-20260504","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1016\/j.dsx.2019.05.028","article-title":"Gastrointestinal symptoms in patients with diabetes mellitus and non-diabetic: A cross-sectional study in North of Iran","volume":"13","author":"Asgharnezhad","year":"2019","journal-title":"Diabetes Metab Syndr"},{"key":"R14-20260504","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1097\/MEG.0b013e3282f5f75e","article-title":"Are gastrointestinal symptoms related to diabetes mellitus and glycemic control?","volume":"20","author":"Koch","year":"2008","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"R15-20260504","doi-asserted-by":"crossref","first-page":"265","DOI":"10.3349\/ymj.2003.44.2.265","article-title":"Colonic transit time in diabetic patients \u2013Comparison with healthy subjects and the effect of autonomic neuropathy","volume":"44","author":"Jung","year":"2003","journal-title":"Yonsei Med J"},{"key":"R16-20260504","doi-asserted-by":"crossref","first-page":"427","DOI":"10.3109\/00365529309098244","article-title":"Gastrointestinal symptoms in middle-aged diabetic patients","volume":"28","author":"Janatuinen","year":"1993","journal-title":"Scand J Gastroenterol"},{"key":"R17-20260504","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1080\/003655200750024317","article-title":"Upper gastrointestinal symptoms in a U. 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National sample of adults with diabetes","volume":"35","author":"Ricci","year":"2000","journal-title":"Scand J Gastroenterol"}],"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_123_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:25:58Z","timestamp":1787837158000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_123_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,26]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/aam.aam_123_25","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,26]]},"assertion":[{"value":"2025-04-19","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-04","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}