{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T21:39:20Z","timestamp":1793569160230,"version":"4.5.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Effective plaque control is essential for preventing caries and periodontal diseases. While curcumin-mediated photodynamic therapy has demonstrated antimicrobial efficacy, its clinical use is limited by poor solubility and bioavailability. This study evaluates a curcumin-loaded liposomal photodynamic gel for enhanced\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      plaque control.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      Curcumin was encapsulated in phosphatidylcholine-based liposomes and incorporated into a bioadhesive gel. Physicochemical properties, including particle size, zeta potential, and encapsulation efficiency, were characterized. Singlet oxygen (\n                      <jats:sup>1<\/jats:sup>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      ) generation was measured under blue light (450 nm) using the 1,3-diphenylisobenzofuran assay. A multispecies oral biofilm model was established with\n                      <jats:italic toggle=\"yes\">Streptococcus mutans, Lactobacillus casei, Actinomyces viscosus<\/jats:italic>\n                      , and\n                      <jats:italic toggle=\"yes\">Fusobacterium nucleatum<\/jats:italic>\n                      . Biofilms were treated with curcumin gel \u00b1 light, and bacterial viability was quantified.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The liposomal gel exhibited a mean particle size of ~ 250 nm, encapsulation efficiency of ~ 85%, and pH of ~ 6.8. Curcumin liposomal gel generated a higher\n                      <jats:sup>1<\/jats:sup>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      yield than free curcumin. Photodynamic treatment reduced viable biofilm bacteria by &gt; 4 log\n                      <jats:sub>10<\/jats:sub>\n                      CFU\/ml, significantly more than control treatments.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Curcumin liposomal gel shows enhanced\n                      <jats:sup>1<\/jats:sup>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      production and potent photodynamic biofilm inactivation. This formulation may offer a novel adjunct for nonantibiotic plaque control.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aam.aam_125_26","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T07:00:10Z","timestamp":1784185210000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Curcumin Liposomal Photodynamic Gel for Plaque Control: Physicochemistry, Singlet-oxygen Yield, and Biofilm Kill Curves \u2013 An In vitro Study"],"prefix":"10.4103","author":[{"given":"Abinash","family":"Mohapatra","sequence":"first","affiliation":[{"name":"Department of Pedodontics and Preventive Dentistry, Kalinga Institute of Dental Sciences, KIIT University, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antarmayee","family":"Panigrahi","sequence":"additional","affiliation":[{"name":"Department of Pedodontics and Preventive Dentistry, Kalinga Institute of Dental Sciences, KIIT University, Bhubaneswar, Odisha, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Snigdha","family":"Pattanaik","sequence":"additional","affiliation":[{"name":"Department of Orthodontics, Pediatric and Community Dentistry, University of Sharjah, Sharjah, UAE"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,7,15]]},"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_125_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T18:56:57Z","timestamp":1785697017000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_125_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,15]]},"references-count":0,"URL":"https:\/\/doi.org\/10.4103\/aam.aam_125_26","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,15]]},"assertion":[{"value":"2026-02-06","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-27","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}