{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T20:39:40Z","timestamp":1786653580795,"version":"build-2736575974"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T00:00:00Z","timestamp":1753228800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,5]]},"abstract":"Abstract<\/jats:title>\n \n Background:<\/jats:title>\n Cancer remains a significant public health concern globally, with increasing incidence in developing countries like India. While chemotherapy has improved survival rates, the quality of life and psychological well-being of cancer patients frequently deteriorate due to treatment-related toxicities, including electrolyte disturbances and psychological effects. This study aimed to examine the differential impact of platinum-based chemotherapy versus other regimens on Health-related Quality of Life (HRQoL) and Hospital Anxiety and Depression Scale (HADS) scores in cancer patients.<\/jats:p>\n <\/jats:sec>\n \n Methodology:<\/jats:title>\n \n This cross-sectional observational study enrolled 90 cancer patients from a tertiary care center in western India between October 2023 and February 2025. Patients were categorized into three groups based on treatment: platinum-based chemotherapy (\n n<\/jats:italic>\n = 32), combination chemotherapy (\n n<\/jats:italic>\n = 28), and other treatments including immunotherapy and hormonal therapy (\n n<\/jats:italic>\n = 30). Serum electrolytes were analyzed, and patients completed the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 for HRQoL assessment and HADS questionnaire. Data were analyzed using SPSS version 21, with\n P<\/jats:italic>\n < 0.05 considered statistically significant.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Patients receiving platinum-based chemotherapy showed significantly worse HRQoL scores (mean: 55.4 \u00b1 10.2) compared to combination therapy (62.8 \u00b1 9.7) and other treatments (71.3 \u00b1 8.5,\n P<\/jats:italic>\n < 0.001). Similarly, HADS scores were highest in the platinum group (13.8 \u00b1 3.4), indicating moderate anxiety and depression, compared to combination therapy (9.6 \u00b1 2.7) and other treatments (6.2 \u00b1 2.1,\n P<\/jats:italic>\n < 0.001). Potassium and phosphate abnormalities were significantly more common in patients receiving platinum-based regimens (\n P<\/jats:italic>\n < 0.05) and correlated with poorer HRQoL and higher HADS scores.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Platinum-based chemotherapy is associated with significantly worse HRQoL, higher anxiety and depression scores, and more frequent electrolyte disturbances compared to other treatment modalities. Regular monitoring of psychological well-being and electrolyte levels, along with appropriate supportive care interventions, should be integrated into routine cancer management, particularly for patients receiving platinum-based regimens.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/aam.aam_128_25","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T17:01:53Z","timestamp":1753290113000},"page":"574-578","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Platinum-based versus Other Chemotherapies on Health-related Quality of Life and Hospital Anxiety and Depression Scale in Patients with Malignancies in a Tertiary Center in Western India"],"prefix":"10.4103","volume":"25","author":[{"given":"Bhumika","family":"Vaishnav","sequence":"first","affiliation":[{"name":"Department of General Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saish Nitin","family":"Mondkar","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,7,23]]},"reference":[{"key":"R1-20260504","first-page":"209","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"R2-20260504","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/S1470-2045(12)70211-5","article-title":"Global cancer transitions according to the Human Development Index (2008-2030): A population-based study","volume":"13","author":"Bray","year":"2012","journal-title":"Lancet Oncol"},{"key":"R3-20260504","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2991\/jegh.k.191008.001","article-title":"Current cancer epidemiology","volume":"9","author":"Mattiuzzi","year":"2019","journal-title":"J Epidemiol Glob Health"},{"key":"R4-20260504","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1200\/GO.20.00122","article-title":"Cancer statistics, 2020: Report from national cancer registry programme, India","volume":"6","author":"Mathur","year":"2020","journal-title":"JCO Glob Oncol"},{"key":"R5-20260504","doi-asserted-by":"crossref","DOI":"10.20517\/2394-4722.2019.008","article-title":"Electrolyte disorders in cancer patients: A systematic review","author":"Berardi","year":"2019","journal-title":"J Cancer Metastasis Treat"},{"key":"R6-20260504","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1080\/0886022X.2020.1735417","article-title":"Electrolyte and acid-base disorders in cancer patients and its impact on clinical outcomes: Evidence from a real-world study in China","volume":"42","author":"Li","year":"2020","journal-title":"Ren Fail"},{"key":"R7-20260504","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/dar.12504","article-title":"Social costs of illegal drugs, alcohol and tobacco in the European Union: A systematic review","volume":"36","author":"Barrio","year":"2017","journal-title":"Drug Alcohol Rev"},{"key":"R8-20260504","first-page":"3249","article-title":"Prevalence of oral mucositis, dry mouth, and dysphagia in advanced cancer patients","volume":"23","author":"Mercadante","year":"2015","journal-title":"Support Care Cancer"},{"key":"R9-20260504","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejim.2007.04.016","article-title":"Causes and mechanisms of acid-base and electrolyte abnormalities in cancer patients","volume":"19","author":"Miltiadous","year":"2008","journal-title":"Eur J Intern Med"},{"key":"R10-20260504","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.semnephrol.2010.09.002","article-title":"Electrolyte disturbances and acute kidney injury in patients with cancer","volume":"30","author":"Lameire","year":"2010","journal-title":"Semin Nephrol"},{"key":"R11-20260504","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.critrevonc.2016.03.010","article-title":"Hyponatremia in cancer patients: Time for a new approach","volume":"102","author":"Berardi","year":"2016","journal-title":"Crit Rev Oncol Hematol"},{"key":"R12-20260504","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jad.2012.03.025","article-title":"Anxiety and depression after cancer diagnosis: Prevalence rates by cancer type, gender, and age","volume":"141","author":"Linden","year":"2012","journal-title":"J Affect Disord"},{"key":"R13-20260504","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S1470-2045(11)70002-X","article-title":"Prevalence of depression, anxiety, and adjustment disorder in oncological, haematological, and palliative-care settings: A meta-analysis of 94 interview-based studies","volume":"12","author":"Mitchell","year":"2011","journal-title":"Lancet Oncol"}],"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_128_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:39:33Z","timestamp":1786649973000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_128_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,23]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/aam.aam_128_25","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,23]]},"assertion":[{"value":"2025-04-21","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-02","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}