{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T20:15:56Z","timestamp":1787343356038,"version":"build-2736575974"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10]]},"abstract":"\n Background:<\/jats:title>\n UTI is the most common nosocomial infection among hospitalized patients. Emerging increasing resistance has been observed among uropathogens of the family enterobacterales. Extended spectrum beta lactamase genes encode for multidrug resistance and unrestricted use of antibiotics in hospitals provides an environment for spread of infections with limited treatment options. This necessitates therapies based on culture and antimicrobial sensitivity to improve patients\u2019 outcomes We aimed to determine susceptibility pattern of ESBL uropathogens among hospitalized patients in Aminu Kano Teaching Hospital, Kano.<\/jats:p>\n <\/jats:sec>\n \n Methodology:<\/jats:title>\n Three hundred and eighty-nine urine samples were obtained from in-patients with UTI between April 2020 and April 2021. Five samples were rejected and remaining analyzed. Susceptibility testing was done by modified Kirby Bauer technique. Clinical Laboratory Standards Institute guidelines 2019 (CLSI 2019) and the European Committee on Antimicrobial Susceptibility testing guidelines version 2 (EUCAST version 2) were used for screening and confirmation of ESBL production respectively.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Of the 384-urine processed, 105 (27.3%) were gram negatives and 81 were Enterobacterales, Isolation rates were\n E. coli<\/jats:italic>\n -55.6%,\n K. pneumoniae<\/jats:italic>\n -29.6%,\n Citrobacter spp<\/jats:italic>\n .-12.3%,\n P. mirabilis<\/jats:italic>\n -1.2% and\n Morganella spp<\/jats:italic>\n .-1.2%. Among Enterobacterales, 32 (39.5%) were ESBL producers. Prevalence of ESBL were 62.5% for\n Escherichia coli<\/jats:italic>\n , 28.1% for\n Klebsiella pneumoniae<\/jats:italic>\n and 9.4% for\n Citrobacter species<\/jats:italic>\n . Susceptibility showed that ESBL-producing Isolates were highly susceptible to amikacin (96.9%). Resistance to other antibiotics varied from 3.1% to 100%.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n We recommend strengthening laboratory capacity, antibiotics stewardship and Infection control to prevent spread of resistant pathogens including ESBLs.<\/jats:p>\n <\/jats:sec>","DOI":"10.4103\/aam.aam_155_22","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T13:00:45Z","timestamp":1699621245000},"page":"508-514","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Antimicrobial Susceptibility Pattern of Extended-Spectrum Beta-Lactamase-Producing Uropathogens in Aminu Kano Teaching Hospital, Northwestern Nigeria"],"prefix":"10.4103","volume":"22","author":[{"given":"Usman Yahya","family":"Umar","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Aminu Kano Teaching Hospital, Kano, Nigeria"},{"name":"Nigeria Field Epidemiology and Laboratory Training Programme, Abuja, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima Jummai","family":"Giwa","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Basic Clinical Sciences, College of Medical Sciences, Ahmadu Bello University, Zaria, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulrasul","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Basic Clinical Sciences, College of Medical Sciences, Ahmadu Bello University, Zaria, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farida Suleiman","family":"Gachi","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Parasitology, Modibbo Adama University Teaching Hospital, Yola, Adamawa State, 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