{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:19:58Z","timestamp":1787840398615,"version":"build-2784847793"},"reference-count":5,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:00:00Z","timestamp":1755648000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Cytomegalovirus (CMV) is a herpes virus that usually affects immunocompromised hosts. However, there has been a recent increase in CMV-associated infections in immunocompetent hosts, with the most common sites including the gastrointestinal tract, lungs, liver, and spleen. We present a case of a 60-year-old male patient who presented with abdominal pain and diarrhea with radiological findings including circumferential mural thickening in the rectum, rectosigmoid, and descending colon with loss of haustrations in the transverse colon suggestive of colitis with toxic megacolon. A subtotal colectomy was performed, which showed gross features of inflammatory bowel disease; however, histopathological findings were suggestive of CMV colitis with typical nuclear and cytoplasmic features. The patient succumbed to death within 2 weeks postsurgery. This case emphasizes the fact that an immunocompetent host present with dreaded complications of CMV colitis, especially older patients, hence elderly age being one of the vulnerable groups.<\/jats:p>","DOI":"10.4103\/aam.aam_194_25","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T09:00:09Z","timestamp":1755680409000},"page":"983-985","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Cytomegalovirus-associated Toxic Megacolon in an Immunocompetent Host: Is It Really That Uncommon?"],"prefix":"10.4103","volume":"25","author":[{"given":"Pallavi","family":"Srivastava","sequence":"first","affiliation":[{"name":"Department of Pathology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankit","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shipra","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,8,20]]},"reference":[{"key":"R1-20260803","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1743-422X-5-47","article-title":"Severe cytomegalovirus infection in apparently immunocompetent patients: A systematic review","volume":"5","author":"Rafailidis","year":"2008","journal-title":"Virol J"},{"key":"R2-20260803","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1080\/00365549850161098","article-title":"Cytomegalovirus colitis in the immunocompetent host: An overview","volume":"30","author":"Klauber","year":"1998","journal-title":"Scand J Infect Dis"},{"key":"R3-20260803","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1002\/jmv.21712","article-title":"Recurrent cytomegalovirus colitis with megacolon in an immunocompetent elderly man","volume":"82","author":"Lin","year":"2010","journal-title":"J Med Virol"},{"key":"R4-20260803","doi-asserted-by":"crossref","first-page":"552","DOI":"10.12998\/wjcc.v8.i3.552","article-title":"Cytomegalovirus ileo-pancolitis presenting as toxic megacolon in an immunocompetent patient: A case report","volume":"8","author":"Cho","year":"2020","journal-title":"World J Clin Cases"},{"key":"R5-20260803","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.4049\/jimmunol.176.4.2645","article-title":"Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and an increased number of dysfunctional cytomegalovirus-specific T cells in the very elderly","volume":"176","author":"Hadrup","year":"2006","journal-title":"J Immunol"}],"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_194_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:22:01Z","timestamp":1787836921000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_194_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,20]]},"references-count":5,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/aam.aam_194_25","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,20]]},"assertion":[{"value":"2025-05-22","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-14","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}