{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:32:27Z","timestamp":1786649547303,"version":"build-2736575974"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    Malaria is a severe health issue in India despite government efforts. Malaria has many complications, some of which can be life-threatening. Disseminated intravascular coagulation (DIC) is a prominent malaria complication, besides renal failure, cerebral malaria, pulmonary edema, and anemia. We report a young man with\n                    <jats:italic toggle=\"yes\">Plasmodium vivax<\/jats:italic>\n                    malaria who developed septic shock due to DIC. A 25-year-old male had a fever, abdominal pain, vomiting, and nausea for 5 days. On clinical examination, the patient was in distress and had a fever of 102.6\u00b0F with a blood pressure of 86\/46 mmHg. A complete blood count revealed anemia, leukocytopenia, and severe thrombocytopenia. Peripheral blood smear findings showed a\n                    <jats:italic toggle=\"yes\">P. vivax<\/jats:italic>\n                    parasite in red blood cells with the presence of a few schistocytes. Further coagulation tests showed raised prothrombin, partial thromboplastin time, and d-dimer. DIC and septic shock required critical care unit admission. Conservative treatment with artesunate and lumefantrine completely cured him. This unusual case shows that\n                    <jats:italic toggle=\"yes\">P. vivax<\/jats:italic>\n                    causes severe malaria and its morbid consequences. It stresses early diagnosis and treatment to prevent mortality and morbidity.\n                  <\/jats:p>","DOI":"10.4103\/aam.aam_195_23","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T06:00:15Z","timestamp":1729663215000},"page":"194-197","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["An Uncommon Case of Plasmodium vivax Malaria with Disseminated Intravascular Coagulation: Rare Case Report with Review of Literature"],"prefix":"10.4103","volume":"24","author":[{"given":"Anuragani","family":"Verma","sequence":"first","affiliation":[{"name":"Department of Microbiology, King George Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anurag","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pathology, King George Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shalini","family":"Rawat","sequence":"additional","affiliation":[{"name":"Department of Pathology, King George Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Kushwaha","sequence":"additional","affiliation":[{"name":"Department of Pathology, King George Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,10,23]]},"reference":[{"key":"R2-20260427","doi-asserted-by":"crossref","first-page":"1.","DOI":"10.1186\/s40101-020-00251-9","article-title":"Plasmodium-a brief introduction to the parasites causing human malaria and their basic biology","volume":"40","author":"Sato","year":"2021","journal-title":"J Physiol 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Dis"},{"key":"R10-20260427","doi-asserted-by":"crossref","first-page":"171","DOI":"10.4103\/0300-1652.129665","article-title":"Disseminated intravascular coagulation in malaria: A case report","volume":"55","author":"Sailo","year":"2014","journal-title":"Niger Med J"},{"key":"R11-20260427","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1111\/j.1476-5381.2009.00251.x","article-title":"Protective mechanisms of activated protein C in severe inflammatory disorders","volume":"158","author":"Neyrinck","year":"2009","journal-title":"Br J Pharmacol"},{"key":"R12-20260427","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1128\/CMR.00074-12","article-title":"Evidence and implications of mortality associated with acute Plasmodium vivax malaria","volume":"26","author":"Baird","year":"2013","journal-title":"Clin Microbiol Rev"},{"key":"R13-20260427","doi-asserted-by":"crossref","first-page":"10.","DOI":"10.1186\/s40249-018-0392-9","article-title":"Severe thrombocytopaenia in patients with vivax malaria compared to falciparum malaria: A systematic review and meta-analysis","volume":"7","author":"Naing","year":"2018","journal-title":"Infect Dis Poverty"},{"key":"R14-20260427","doi-asserted-by":"crossref","first-page":"63.","DOI":"10.1186\/1475-2875-9-63","article-title":"Congenital Plasmodium vivax malaria mimicking neonatal sepsis: A case report","volume":"9","author":"Del Punta","year":"2010","journal-title":"Malar J"}],"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_195_23","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T18:55:13Z","timestamp":1786647313000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_195_23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,23]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.4103\/aam.aam_195_23","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,23]]},"assertion":[{"value":"2023-11-18","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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