{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:13:03Z","timestamp":1789560783261,"version":"build-2803163510"},"reference-count":7,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 2","license":[{"start":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T00:00:00Z","timestamp":1776384000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Systemic lupus erythematosus (SLE) is a chronic, inflammatory, autoimmune disorder involving multiple systems. A 18-year-old female patient presented with complaints of headache, weakness, and tingling sensation in the left upper limb and lower limb. On magnetic resonance imaging (MRI), acute nonhemorrhagic infarct in right thalamo-capsular region was seen. The patient gave a history of malar rash and intermittent joint pains for which she had taken nonspecific treatment. Antineutrophilic antibody (ANA) by innumoflourescence and ANA blot was suggestive of SLE. Hence, the patient had central nervous system vasculitis and stroke due to SLE. The patient was started on antiplatelet therapy, tablet prednisolone 40 mg once daily, and tablet warfarin 5 mg once daily. The patient was readmitted after 2 weeks with menorrhagia and deranged INR. Tablet Warfarin was with-held, fresh frozen plasma transfusions were given. Repeat MRI did not show any new changes. Patient was given tablet nicoumalone and three doses of injection cyclophosphamide 800 mg. Hemiplegia has improved by 90%, her menstrual cycles are now regular.<\/jats:p>","DOI":"10.4103\/aam.aam_207_26","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T06:00:09Z","timestamp":1776405609000},"page":"S415-S417","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Stroke in Young Female as a Presenting Feature of Systemic Lupus Erythematosus with Central Nervous System Vasculitis and Its Management"],"prefix":"10.4103","volume":"25","author":[{"given":"Vijayashree S","family":"Gokhale","sequence":"first","affiliation":[{"name":"Department of General Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avuthu","family":"Hemanjali","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divam Prakash","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Triveen Varma","family":"Vetukuri","sequence":"additional","affiliation":[{"name":"Department of General Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,4,17]]},"reference":[{"key":"R1-20260916","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1177\/0961203317694259","article-title":"Central nervous system vasculitis in systemic lupus erythematosus: A case series report in a tertiary referral centre","volume":"26","author":"Rodrigues","year":"2017","journal-title":"Lupus"},{"key":"R2-20260916","doi-asserted-by":"crossref","first-page":"7","DOI":"10.31138\/mjr.30.1.7","article-title":"Cerebrovascular events in systemic lupus erythematosus: Diagnosis and management","volume":"30","author":"Nikolopoulos","year":"2019","journal-title":"Mediterr J Rheumatol"},{"key":"R3-20260916","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.jfma.2023.09.018","article-title":"The characteristics and risk factors of cerebrovascular events in young systemic lupus erythematosus patients: A case-control study","volume":"123","author":"Hsu","year":"2024","journal-title":"J Formos Med Assoc"},{"key":"R4-20260916","doi-asserted-by":"crossref","first-page":"e70606","DOI":"10.1002\/ccr3.70606","article-title":"Stroke in the young: A case of CNS vasculitis secondary to systemic lupus erythematosus","volume":"13","author":"Badir","year":"2025","journal-title":"Clin Case Rep"},{"key":"R5-20260916","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/s41581-023-00797-8","article-title":"Vascular damage in systemic lupus erythematosus","volume":"20","author":"Ambler","year":"2024","journal-title":"Nat Rev Nephrol"},{"key":"R6-20260916","doi-asserted-by":"crossref","first-page":"733","DOI":"10.3390\/jcm14030733","article-title":"Antiphospholipid syndrome: A comprehensive clinical review","volume":"14","author":"Patriarcheas","year":"2025","journal-title":"J Clin Med"},{"key":"R7-20260916","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1191\/0961203303lu1028oa","article-title":"Cyclophosphamide: New approaches for systemic lupus erythematosus","volume":"13","author":"Petri","year":"2004","journal-title":"Lupus"}],"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_207_26","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:00:57Z","timestamp":1789560057000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_207_26"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,17]]},"references-count":7,"journal-issue":{"issue":"Suppl 2","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/aam.aam_207_26","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,17]]},"assertion":[{"value":"2026-02-25","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-30","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}