{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:36:33Z","timestamp":1787070993177,"version":"build-2736575974"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This case report aims to disclose intentional overdosing of drugs that impact the cardiovascular and central nervous systems which have very serious and life-threatening effects on the body. In the present case study, a 22-year-old male medical student with a known history of depression and recurrent episodes of suicide who was on regular psychiatric medications purposefully consumed an unknown quantity of clonazepam, prazosin, ivabradine, and propranolol in an attempt of suicide in a powdered form. He was brought to the emergency department by his parents with signs of severe bradycardia, hypotension, and respiratory failure; his heart rate remained low despite prompt intervention by medications to maintain heart rate, and temporary installation of a pacemaker was done to maintain heart rate. Lipid emulsion therapy, also known as intralipid, was started to maintain blood pressure despite using medications. The patient was also put on vasopressin assistance to prevent further damage to vital organs and death. This case report highlights the importance of early detection, vigorous cardiovascular stabilization, prompt intervention, and comprehensive psychological management in preventing recurrence in such cases of fatal polypharmacy cases.<\/jats:p>","DOI":"10.4103\/aam.aam_208_25","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T11:00:20Z","timestamp":1757415620000},"page":"725-727","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Intentional Ingestion and Multidisciplinary Management in a Fatal Polypharmacy Overdose"],"prefix":"10.4103","volume":"25","author":[{"given":"Swapnil","family":"Patil","sequence":"first","affiliation":[{"name":"Department of General Medicine, D. Y. Patil Medical College and Research Centre, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivraj Prashant","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of General Medicine, D. Y. Patil Medical College and Research Centre, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"key":"R1-20260504","first-page":"247","article-title":"Beta-blocker and calcium-channel blocker toxicity: Current evidence on evaluation and management","volume":"13","author":"Goldfine","year":"2024","journal-title":"Eur Heart J Acute Cardiovasc Care"},{"key":"R2-20260504","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jad.2013.01.004","article-title":"Risk factors for suicide in individuals with depression: A systematic review","volume":"147","author":"Hawton","year":"2013","journal-title":"J Affect Disord"},{"key":"R3-20260504","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1757-7241-17-29","article-title":"Management of the critically poisoned patient","volume":"17","author":"Boyle","year":"2009","journal-title":"Scand J Trauma Resusc Emerg Med"},{"key":"R5-20260504","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.3390\/pharmaceutics15051396","article-title":"Lipid emulsion to treat acute poisonings: Mechanisms of action, indications, and controversies","volume":"15","author":"Jaffal","year":"2023","journal-title":"Pharmaceutics"},{"key":"R6-20260504","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/bcp.12763","article-title":"Calcium channel antagonist and beta-blocker overdose: Antidotes and adjunct therapies","volume":"81","author":"Graudins","year":"2016","journal-title":"Br J Clin Pharmacol"},{"key":"R7-20260504","doi-asserted-by":"crossref","DOI":"10.1093\/eurpub\/ckad160.654","article-title":"Mental health and suicidal behaviours among Irish adolescents - Results from the Planet Youth study","volume":"33","author":"Cannon","year":"2023","journal-title":"Eur J Public Health"},{"key":"R8-20260504","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jad.2014.02.026","article-title":"The effects of psychotherapies for major depression in adults on remission, recovery and improvement: A meta-analysis","volume":"159","author":"Cuijpers","year":"2014","journal-title":"J Affect Disord"},{"key":"R9-20260504","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jad.2018.10.115","article-title":"Mental disorders as risk factors for suicidal behavior in young people: A meta-analysis and systematic review of longitudinal studies","volume":"245","author":"Gili","year":"2019","journal-title":"J Affect Disord"}],"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_208_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:40:04Z","timestamp":1787067604000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_208_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,9]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/aam.aam_208_25","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,9]]},"assertion":[{"value":"2025-05-31","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-02","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}