{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:28:59Z","timestamp":1789874939697,"version":"4.0.1"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Afr Med"],"published-print":{"date-parts":[[2018]]},"DOI":"10.4103\/aam.aam_26_17","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T00:43:32Z","timestamp":1516754612000},"page":"11","source":"Crossref","is-referenced-by-count":9,"title":["Assessment of some indicators of oxidative stress in nigerian sickle cell anemic patients"],"prefix":"10.4103","volume":"17","author":[{"given":"Theresa","family":"Nwagha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"CP","family":"Okorie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fidelis","family":"Ejezie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"key-10.4103\/1596-3519.223871-1","first-page":"62","volume-title":"Hematological values in sickle cell anaemia in steady state and during vaso-occlusive crises in Benin City, Nigeria","author":"Omoti","year":"2005","journal-title":"Ann Afr Med","ISSN":"https:\/\/id.crossref.org\/issn\/1596-3519","issn-type":"print"},{"key":"key-10.4103\/1596-3519.223871-2","first-page":"61","volume-title":"Sicklecelldisease indeveloping countries: Magnitude and challenges","author":"Olatunji","year":"2002","journal-title":"Postgrad Doct (Africa)"},{"key":"key-10.4103\/1596-3519.223871-3","unstructured":"WHO. Sickle-Cell Anaemia \u2013 Report by the Secretariat. World Health Oranagziation; 2010. p. 11-27."},{"key":"key-10.4103\/1596-3519.223871-4","first-page":"280","volume-title":"Role of free radicals in the pathogenesis of acute chest syndrome in sickle cell disease","author":"Klings","year":"2001","journal-title":"Respir Res"},{"key":"key-10.4103\/1596-3519.223871-5","first-page":"66","volume-title":"Antioxidants in neonatal systemic disease","author":"Airede","year":"1999","journal-title":"Sahel Med J","ISSN":"https:\/\/id.crossref.org\/issn\/1118-8561","issn-type":"print"},{"key":"key-10.4103\/1596-3519.223871-6","first-page":"693","volume-title":"Antioxidant defences in the lung","author":"Fridovich","year":"1986","journal-title":"Annu Rev Physiol"},{"key":"key-10.4103\/1596-3519.223871-7","unstructured":"Halliwell B, Gutteridge JM. Free Radicals in Biology and Medicine. 4th ed. New York: Oxford University Press; 2007. p. 888."},{"key":"key-10.4103\/1596-3519.223871-8","first-page":"1253","volume-title":"Spontaneous oxygen radical generation by sickle erythrocytes","author":"Hebbel","year":"1982","journal-title":"J Clin Invest"},{"key":"key-10.4103\/1596-3519.223871-9","first-page":"609","volume-title":"Reduced antioxidant capacity in paediatric patients with homozygous sickle cell disease","author":"Adelekan","year":"1989","journal-title":"Eur J Clin Nutr"},{"key":"key-10.4103\/1596-3519.223871-10","first-page":"433","volume-title":"Recent advancements in the LC- and GC-based analysis of malondialdehyde (MDA): A Brief overview","author":"Giera","year":"2012","journal-title":"Chromatographia"},{"key":"key-10.4103\/1596-3519.223871-11","first-page":"168","volume-title":"Pro-oxidant and anti-oxidant status in patients of sickle cell anaemia","author":"Titus","year":"2004","journal-title":"Indian J Clin Biochem"},{"key":"key-10.4103\/1596-3519.223871-12","first-page":"87","volume-title":"Superoxide dismutase, glutathione peroxidase, catalase and lipid peroxidation of normal and sickled erythrocytes","author":"Das","year":"1980","journal-title":"Br J Haematol"},{"key":"key-10.4103\/1596-3519.223871-13","first-page":"37","volume-title":"Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method","author":"Satoh","year":"1978","journal-title":"Clin Chim Acta"},{"key":"key-10.4103\/1596-3519.223871-14","first-page":"177","volume-title":"Determination of nitrite\/nitrate in human biological material by the simple griess reaction","author":"Guevara","year":"1998","journal-title":"Clin Chim Acta"},{"key":"key-10.4103\/1596-3519.223871-15","first-page":"356","volume-title":"Method for the measurement of antioxidant activity in human fluids","author":"Koracevic","year":"2001","journal-title":"J Clin Pathol"},{"key":"key-10.4103\/1596-3519.223871-16","first-page":"177","volume-title":"Antioxidant enzymes and acute phase proteins correlate with marker of lipid peroxide in adult Nigerian sickle cell disease patients","author":"Emokpae","year":"2010","journal-title":"J Basic Med Sci"},{"key":"key-10.4103\/1596-3519.223871-17","first-page":"766","volume-title":"Evaluation of antioxidant levels and trace elements status in Nigerian sickle cell disease patients with plasmodium parasitaemia","author":"Arinola","year":"2008","journal-title":"Pak J Nutr"},{"key":"key-10.4103\/1596-3519.223871-18","first-page":"891","volume-title":"Total anti-oxidant status in sickle cell disease patients in steady state","author":"Foluke","year":"2008","journal-title":"J Natl Med Assoc"},{"key":"key-10.4103\/1596-3519.223871-19","first-page":"17","volume-title":"Zinc and antioxidant vitamin deficiency in patients with severe sickle cell anemia","author":"Hasanato","year":"2006","journal-title":"Ann Saudi Med","ISSN":"https:\/\/id.crossref.org\/issn\/0256-4947","issn-type":"print"},{"key":"key-10.4103\/1596-3519.223871-20","first-page":"104","volume-title":"Sickle cell anemia is associated with reduced nitric oxide bioactivity in peripheral conduit and resistance vessels","author":"Eberhardt","year":"2003","journal-title":"Am J Hematol"},{"key":"key-10.4103\/1596-3519.223871-21","doi-asserted-by":"crossref","unstructured":"Rother RP, Bell L, Hillmen P, Gladwin MT. The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: A novel mechanism of human disease. JAMA 2005;293:1653-62.","DOI":"10.1001\/jama.293.13.1653"},{"key":"key-10.4103\/1596-3519.223871-22","first-page":"1383","volume-title":"Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease","author":"Reiter","year":"2002","journal-title":"Nat Med"},{"key":"key-10.4103\/1596-3519.223871-23","first-page":"81","volume-title":"Dysregulated arginine metabolism, hemolysis-associated pulmonary hypertension, and mortality in sickle cell disease","author":"Morris","year":"2005","journal-title":"JAMA"},{"key":"key-10.4103\/1596-3519.223871-24","first-page":"3391","volume-title":"The accumulation of malonyldialdehyde, a product of fatty acid peroxidation, can disturb aminophospholipid organization in the membrane bilayer of human erythrocytes","author":"Jain","year":"1984","journal-title":"J Biol Chem"},{"key":"key-10.4103\/1596-3519.223871-25","doi-asserted-by":"crossref","unstructured":"Chiu D, Lubin B, Shohet SB. Peroxidative reactions in red cell biology. In: Pryor W, editor. Free Radicals in Biology. New York: Academic Press; 1982. p. 115-60.","DOI":"10.1016\/B978-0-12-566505-6.50012-0"},{"key":"key-10.4103\/1596-3519.223871-26","first-page":"501","volume-title":"Non-specific recognition in phagocytosis: Ingestion of aldehyde-treated erythrocytes by rat peritoneal macrophages","author":"Capo","year":"1979","journal-title":"Immunology"},{"key":"key-10.4103\/1596-3519.223871-27","first-page":"1278","volume-title":"Nonheme iron in sickle erythrocyte membranes: Association with phospholipids and potential role in lipid peroxidation","author":"Kuross","year":"1988","journal-title":"Blood"},{"key":"key-10.4103\/1596-3519.223871-28","first-page":"633","volume-title":"Denatured hemoglobin in sickle erythrocytes","author":"Asakura","year":"1977","journal-title":"J Clin Invest"},{"key":"key-10.4103\/1596-3519.223871-29","first-page":"542","volume-title":"Abnormal Vitamin E and glutathione peroxidase levels in sickle cell anemia: Evidence for increased susceptibility to lipid peroxidation in vivo","author":"Chiu","year":"1979","journal-title":"J Lab Clin Med"},{"key":"key-10.4103\/1596-3519.223871-30","first-page":"48","volume-title":"Plasma levels of retinol, ascorbic acid and alpha-tocopherol in sickle cell anaemia","author":"Essien","year":"1995","journal-title":"Cent Afr J Med"},{"key":"key-10.4103\/1596-3519.223871-31","first-page":"467","volume-title":"Efficacy of zinc therapy in prevention of crisis in sickle cell anemia: A double blind, randomized controlled clinical trial","author":"Gupta","year":"1995","journal-title":"J Assoc Physicians India"}],"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:36:16Z","timestamp":1786714576000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_26_17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018]]}},"alternative-id":["223871"],"URL":"https:\/\/doi.org\/10.4103\/aam.aam_26_17","relation":{},"ISSN":["1596-3519"],"issn-type":[{"value":"1596-3519","type":"print"}],"subject":[],"published":{"date-parts":[[2018]]}}}