{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:21:29Z","timestamp":1788182489071,"version":"build-2803163510"},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Community-acquired pneumonia (CAP) remains a leading cause of illness and death in children under five. Early identification of severe cases is critical. This study evaluates hematological parameters \u2013 neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), red cell distribution width (RDW), and thrombocytopenia \u2013 as prognostic markers in pediatric CAP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      A case\u2013control study was conducted among 400 children aged 2\u201359 months with CAP at a tertiary care hospital. There were 3 groups labeled as a control group and a patient group, which is divided into pneumonia and severe pneumonia groups based on the Integrated Management of Neonatal and Child hood Illness (IMNCI) guidelines. Hematological indices were analyzed using\n                      <jats:italic toggle=\"yes\">t<\/jats:italic>\n                      -tests, Chi-square tests, and receiver operating characteristic curve analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      Among 400 participants aged 2\u201359 months, younger age (2\u201320 months) and male gender were associated with higher pneumonia severity. Hemoglobin, hematocrit, NLR, PLR, and RDW showed statistically significant associations with pneumonia severity. The NLR correlates with the severity of pneumonia. The PLR correlates statistically with pneumonia severity, evidenced by a statistically significant\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value. RDW is considered an important parameter for assessing pneumonia severity, demonstrated by a highly significant\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      value. Hence, these parameters emerged as a promising inflammatory marker for severe pediatric pneumonia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>NLR, PLR, RDW, and thrombocytopenia are simple, cost-effective markers that can aid in early identification of severe pediatric CAP, improving clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aam.aam_287_25","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T08:00:43Z","timestamp":1784880043000},"page":"1114-1119","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Estimation of Hematological Parameters Including Neutrophil-to-lymphocyte Ratio, Platelet-to-lymphocyte Ratio, and Red Cell Distribution Width in Childhood Community-acquired Pneumonia and Its Relation with the Disease Severity: A Case\u2013Control Study"],"prefix":"10.4103","volume":"25","author":[{"given":"Partha Kumar","family":"Chaudhuri","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranvijay","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shambhavi","family":"Datta","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pratik","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, 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