{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T13:46:42Z","timestamp":1791812802890,"version":"4.3.4"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"Suppl 3","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Malignant melanoma (MM) uncommonly presents as a solid\u2013cystic soft tissue mass, posing a significant diagnostic challenge. We report a rare case in a 63-year-old woman with neurofibromatosis type 1 (NF-1) who presented with a painful, rapidly progressive swelling on the posterior aspect of her right lower thigh. Imaging revealed a large, well-defined solid\u2013cystic lesion suggestive of a soft tissue sarcoma or malignant peripheral nerve sheath tumor. Initial fine-needle aspiration cytology was nondiagnostic. Definitive diagnosis was achieved following wide surgical excision, with histopathological and immunohistochemical analysis confirming MM (strongly positive for S100, Melan-A, and SOX10). This case highlights that MM must be considered in the differential diagnosis of atypical cystic soft tissue lesions, even in anatomically unexpected locations, especially in patients with predisposing conditions such as NF-1 and affirms the indispensable integration of multimodality imaging with histopathological and immunohistochemical correlation in resolving diagnostically challenging soft tissue masses.<\/jats:p>","DOI":"10.4103\/aam.aam_289_26","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T15:22:47Z","timestamp":1781018567000},"page":"S630-S633","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Melanoma in an Unlikely Guise: Diagnostic Challenges of a Solid\u2013cystic Popliteal Mass in Neurofibromatosis Type 1"],"prefix":"10.4103","volume":"25","author":[{"given":"Ankita Arvind","family":"Pandey","sequence":"first","affiliation":[{"name":"Department of Radiodiagnosis, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (DPU), Pimpri-Chinchwad, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richa Mariam","family":"Roy","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (DPU), Pimpri-Chinchwad, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Purnachandra","family":"Lamghare","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (DPU), Pimpri-Chinchwad, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Archana","family":"Buch","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (DPU), Pimpri-Chinchwad, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"R1-20261012","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1016\/j.jid.2016.01.035","article-title":"The growing burden of invasive melanoma: Projections of incidence rates and numbers of new cases in six susceptible populations through 2031","volume":"136","author":"Whiteman","year":"2016","journal-title":"J Invest Dermatol"},{"key":"R2-20261012","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ejca.2004.10.015","article-title":"Meta-analysis of risk factors for cutaneous melanoma: I. 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