{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:21:21Z","timestamp":1788182481632,"version":"build-2803163510"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Sepsis is a significant maternal health issue; presepsin (sCD14-ST) has emerged as a novel biomarker for diagnosis of sepsis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim:<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the diagnostic accuracy of presepsin for prediction of sepsis in critically ill obstetric patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A prospective observational study was conducted in the Obstetrics Intensive Care Unit (ICU), over 18-month duration, involving 156 critically ill obstetric patients. Biomarkers including presepsin, C-reactive protein (CRP), and total leukocyte count (TLC) were measured on day 1 and day 3 of ICU admission. Presepsin was measured in serum sample by enzyme-linked immunosorbent assay (ELISA) technique using ELISA kit.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      44.9% critically ill obstetrics patients developed sepsis in ICU. The most common comorbidity was acute kidney injury (AKI; 20.0%), and AKI was 28.5% in septic patients. Maternal death occurred in 17.9%, with a significantly higher mortality among those who had sepsis (32.9%) compared to those without sepsis (5.8%). Presepsin levels significantly increased from day 1 value of 260 pg\/mL to day 3 value of 350 pg\/ml, after the development of sepsis (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.001). Those who did not develop sepsis (controls) levels were decreased. Receiver operating characteristic analysis showed presepsin had good diagnostic accuracy for prediction of sepsis presepsin at a cutoff value of \u2265245 pg\/ml had a sensitivity of 84.6% and specificity of 80.0%, at the area under the ROC curve (AUC) = 0.892, with confidence interval of 95% (AUC day 3 &gt; day 1). Presepsin outperformed CRP and TLC in early sepsis detection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Presepsin is a reliable early marker for sepsis in critically ill obstetric patients, with better diagnostic accuracy than CRP and TLC. Its serial monitoring may offer valuable prognostic insight.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aam.aam_315_25","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T15:00:12Z","timestamp":1764082812000},"page":"1133-1139","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Accuracy of Presepsin for Early Diagnosis of Sepsis in Critically Ill Obstetrics Patients"],"prefix":"10.4103","volume":"25","author":[{"given":"Rekha","family":"Sachan","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhey","family":"Shyam","sequence":"additional","affiliation":[{"name":"Department of Geriatric Mental Health, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umang","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munna Lal","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Medicine, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wahid","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Pathology, King George\u2019s Medical University, Lucknow, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"issue":"Suppl 1","key":"R1-20260831","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/j.jinf.2015.04.016","article-title":"Pediatric sepsis in the developing world","volume":"71","author":"Kissoon","year":"2015","journal-title":"J Infect"},{"key":"R2-20260831","doi-asserted-by":"crossref","first-page":"e323","DOI":"10.1016\/S2214-109X(14)70227-X","article-title":"Global causes of maternal death: A WHO systematic analysis","volume":"2","author":"Say","year":"2014","journal-title":"Lancet Glob Health"},{"key":"R3-20260831","first-page":"e8801","article-title":"Severe sepsis and septic shock in intensive care units: A prospective study from a tertiary care hospital in eastern India","volume":"12","author":"Sahoo","year":"2020","journal-title":"Cureus"},{"key":"R4-20260831","doi-asserted-by":"crossref","first-page":"216","DOI":"10.4103\/0972-5229.180042","article-title":"Intensive care in India: The Indian intensive care case mix and practice patterns study","volume":"20","author":"Divatia","year":"2016","journal-title":"Indian J Crit Care Med"},{"key":"R5-20260831","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1164\/rccm.201504-0781OC","article-title":"Assessment of global incidence and mortality of hospital-treated sepsis. 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