{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:21:24Z","timestamp":1788182484058,"version":"build-2803163510"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Due to its rarity and locally aggressive nature, fibromatosis often presents diagnostic challenges. We present a case of a 27-year-old female who presented with a painless, progressively enlarging mass in the left thigh that increased in size from 2 cm \u00d7 2 cm to 10 cm \u00d7 10 cm over 9 months. On physical examination, the mass was firm, immobile, and had well-defined margins. Magnetic resonance imaging (MRI) of the thigh and pelvis suggested soft tissue sarcoma, while histopathological examination of the trucut biopsy specimen demonstrated characteristic features of fibromatosis, including lack of nuclear atypia, proliferation of hypocellular spindle cells, and thick deposition of collagen. Immunohistochemistry confirmed the diagnosis with positive \u03b2-catenin staining and negative staining for desmin, S-100, and CD-34. The patient underwent wide local excision with R0 margins, and postoperative histopathology confirmed fibromatosis. Considering the risk of recurrence, the patient was advised regular follow-up with MRI. At 6-month follow-up, there was no evidence of recurrence.<\/jats:p>","DOI":"10.4103\/aam.aam_337_25","type":"journal-article","created":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T20:00:10Z","timestamp":1764532810000},"page":"1309-1312","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Dilemma and Management of a Rapidly Enlarging Thigh Mass: A Case Report of Fibromatosis Mimicking Soft-tissue Sarcoma"],"prefix":"10.4103","volume":"25","author":[{"given":"Digvijay Jaideepsingh","family":"Jadhav","sequence":"first","affiliation":[{"name":"Department of General Surgery, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shreya Reddy","family":"Nagula","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virendra S","family":"Athavale","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cholleti Raja","family":"Sudhatri","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nithin","family":"Nayani","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,11,27]]},"reference":[{"key":"R1-20260831","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1093\/annonc\/mdx323","article-title":"An update on the management of sporadic desmoid-type fibromatosis: A European Consensus Initiative between Sarcoma PAtients EuroNet (SPAEN) and European Organization for Research and Treatment of Cancer (EORTC)\/Soft Tissue and Bone Sarcoma Group (STBSG)","volume":"28","author":"Kasper","year":"2017","journal-title":"Ann Oncol"},{"key":"R2-20260831","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/CCO.0000000000000374","article-title":"Adult desmoid tumors: Biology, management and ongoing trials","volume":"29","author":"Penel","year":"2017","journal-title":"Curr Opin Oncol"},{"key":"R3-20260831","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1056\/NEJMoa1805052","article-title":"Sorafenib for advanced and refractory desmoid tumors","volume":"379","author":"Gounder","year":"2018","journal-title":"N Engl J Med"},{"key":"R4-20260831","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.2353\/ajpath.2008.080475","article-title":"Specific mutations in the beta-catenin gene (CTNNB1) correlate with local recurrence in sporadic desmoid tumors","volume":"173","author":"Lazar","year":"2008","journal-title":"Am J Pathol"},{"key":"R5-20260831","doi-asserted-by":"crossref","first-page":"W1008","DOI":"10.2214\/AJR.11.6657","article-title":"Ato Z of desmoid tumors","volume":"197","author":"Shinagare","year":"2011","journal-title":"Am J Roentgenol"},{"key":"R6-20260831","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/his.12298","article-title":"Immunohistochemistry of soft tissue tumours \u2013 Review with emphasis on 10 markers","volume":"64","author":"Miettinen","year":"2014","journal-title":"Histopathology"},{"key":"R7-20260831","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1746-1596-8-50","article-title":"Variable Ki67 proliferative index in 65 cases of nodular fasciitis, compared with fibrosarcoma and fibromatosis","volume":"8","author":"Lin","year":"2013","journal-title":"Diagn Pathol"},{"key":"R8-20260831","first-page":"43","article-title":"Management of aggressive fibromatosis","volume":"21","author":"Zhang","year":"2021","journal-title":"Oncol Lett"}],"container-title":["Annals of African Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_337_25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:01:11Z","timestamp":1788181271000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/10.4103\/aam.aam_337_25"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,27]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.4103\/aam.aam_337_25","relation":{},"ISSN":["1596-3519","0975-5764"],"issn-type":[{"value":"1596-3519","type":"print"},{"value":"0975-5764","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,27]]},"assertion":[{"value":"2025-06-14","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-06","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}