{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T13:21:25Z","timestamp":1788182485405,"version":"build-2803163510"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:00:00Z","timestamp":1764201600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Helicobacter pylori<\/jats:italic>\n                      is a globally prevalent pathogen implicated in multiple gastrointestinal malignancies. While its role in gastric cancer is well established, its association with extragastric malignancies such as gallbladder carcinoma (GBC), pancreatic carcinoma (PC), and colorectal carcinoma (CRC) remains contentious.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      To evaluate the prevalence of\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      in gallbladder, pancreatic, and colorectal malignancies and to assess its potential associations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods:<\/jats:title>\n                    <jats:p>\n                      This prospective observational study was conducted between January 2023 and March 2025 at a tertiary hospital in India. Seventy-six histologically confirmed cases of GBC (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 42), CRC (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 24), and PC (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 10) underwent immunohistochemistry testing for\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      . The data were analyzed using SPSS v26.0;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; 0.05 was considered statistically significant.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The overall prevalence of\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      was 22.4%. It was detected in 26.2% of GBC, 8.3% of CRC, and 40% of PC cases. However, no statistically significant association was found between\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      presence and any malignancy type (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &gt; 0.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>\n                      Although\n                      <jats:italic toggle=\"yes\">H. pylori<\/jats:italic>\n                      was detected in a subset of GBC, PC, and CRC cases, the association was not statistically significant. Further multicenter studies with larger cohorts are necessary to explore potential etiological roles.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.4103\/aam.aam_341_25","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T12:00:06Z","timestamp":1764072006000},"page":"1277-1280","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Association of Helicobacter pylori with Gallbladder, Pancreatic, and Colorectal Malignancies: A Prospective Observational Study"],"prefix":"10.4103","volume":"25","author":[{"given":"Anuradha","family":"Dnyanmote","sequence":"first","affiliation":[{"name":"Department of General Surgery, Dr. D. Y. 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